[STUDY GUIDE] • HIGH-YIELD PRACTICE & REVIEW EDITION
RN HESI Pharmacology Exam V2 Questions
& Answers, Latest Updated 2026/2027
Edition
Comprehensive Examination Question Bank • In-Depth Rationales • Concept Mapping
TOTAL QUESTIONS EXAM TOPICS RATIONALES
97 Questions 12 Modules 100% Verified
DOCUMENT OVERVIEW
This document contains 97 verified questions with correct answers and detailed rationales covering
pharmacological principles and drug interactions. It provides comprehensive insights into medication
mechanisms, side effects, and considerations for various health conditions, making it suitable for nursing
education, exam preparation, and professional certification review.
EXAM BLUEPRINT & TOPIC DISTRIBUTION
Systematic breakdown of subject domains and exam coverage.
Topic Module Scope & Core Focus Questions Share (%)
This topic covers various antihypertensive medications, their
mechanisms of action, side effects, and nursing
Antihypertensive Medications considerations. 10 Qs 10.3%
This topic focuses on short-acting and long-acting beta-2
agonists used in asthma management, including their actions
Beta-2 Agonists and patient education. 8 Qs 8.2%
This topic examines the role, mechanisms, and side effects of
ACE inhibitors in managing hypertension and other
ACE Inhibitors conditions. 8 Qs 8.2%
This topic discusses diuretics, their mechanisms of action,
Diuretics effects on electrolyte balance, and nursing implications. 8 Qs 8.2%
This topic analyzes beta-blockers, their effects on heart rate
and blood pressure, and specific considerations in different
Beta-Blockers patient populations. 8 Qs 8.2%
Confidential • Student Study Edition • Practice & Review Guide Page 1 of 50
,STUDENT STUDY & MASTERY EDITION PRACTICE & REVIEW GUIDE
This topic covers anticoagulant medications, their therapeutic
Anticoagulants uses, and the importance of monitoring laboratory values. 8 Qs 8.2%
This topic addresses antibiotic therapy, including indications,
Antibiotics side effects, and considerations for patients with allergies. 8 Qs 8.2%
This topic emphasizes safe medication administration
Medication Administration and practices and the importance of monitoring for adverse
Monitoring effects. 8 Qs 8.2%
This topic focuses on pharmacological management of
Chronic Conditions Management chronic conditions, including diabetes and heart failure. 8 Qs 8.2%
Pharmacokinetics and This topic explores the principles of pharmacokinetics and
Pharmacodynamics pharmacodynamics as they relate to drug therapy. 8 Qs 8.2%
Nursing Considerations in This topic highlights the nursing considerations necessary for
Pharmacotherapy safe pharmacotherapy and patient education. 8 Qs 8.2%
This topic addresses the management of electrolytes in
Electrolyte Management patients receiving diuretics and other medications. 7 Qs 7.2%
Total Exam Coverage 12 Integrated Topic Modules 97 Qs 100.0%
Confidential • Student Study Edition • Practice & Review Guide Page 2 of 50
,STUDENT STUDY & MASTERY EDITION PRACTICE & REVIEW GUIDE
TOPIC 1: ANTIHYPERTENSIVE MEDICATIONS
10 Questions • 10.3% of Exam • This topic covers various antihypertensive medications, their mechanisms of action, side effects, and
nursing considerations.
QUESTION 1
A 45-year-old client with hypertension is prescribed enalapril and tells the nurse that he
has been taking atenolol for 2 years. What instruction should the nurse provide
regarding the new medication?
[A] To continue taking atenolol as prescribed and start enalapril at the next scheduled dose.
[B] To stop taking atenolol as soon as enalapril starts and report any side effects.
[C] To take enalapril as directed and notify the healthcare provider if they experience any side effects from stopping
atenolol.
[D] To report to the healthcare provider that they have been taking atenolol for 2 years and ask if they should stop taking it.
Correct Answer: C. To take enalapril as directed and notify the healthcare provider if they experience any
side effects from stopping atenolol.
Rationale: The nurse should instruct the client to take enalapril as directed and report any side effects from stopping
atenolol.
QUESTION 2
A 60-year-old male client with hypertension is prescribed enalapril. What is a potential
side effect of this medication?
[A] Increased potassium levels.
[B] Decreased potassium levels.
[C] Increased sodium levels.
[D] Cough and angioedema.
Correct Answer: D. Cough and angioedema.
Rationale: Enalapril can cause cough and angioedema as a potential side effect.
Confidential • Student Study Edition • Practice & Review Guide Page 3 of 50
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QUESTION 3
A 62-year-old male client is prescribed enalapril for hypertension. He also has a history
of chronic kidney disease (CKD). Which precaution should the nurse take when
administering enalapril?
[A] Monitor for signs of renal failure
[B] Administer with food to reduce gastrointestinal side effects
[C] Hold the medication in case of a kidney stone
[D] Increase the dose to enhance diuretic effect
Correct Answer: A. Monitor for signs of renal failure.
Rationale: Enalapril is contraindicated in clients with bilateral renal artery stenosis or unilateral stenosis in a solitary kidney.
QUESTION 4
A 55-year-old client is prescribed enalapril for hypertension. The nurse reviews the
medication list and notes that the client is currently taking atenolol. Which instruction
should the nurse provide to the client regarding the new medication?
[A] To discontinue atenolol use immediately.
[B] To gradually taper off atenolol over a 2-week period.
[C] To continue taking atenolol as prescribed and start enalapril as directed.
[D] To stop taking atenolol for 24 hours before starting enalapril.
Correct Answer: C. To continue taking atenolol as prescribed and start enalapril as directed.
Rationale: Enalapril can be initiated concurrently with atenolol without tapering.
Confidential • Student Study Edition • Practice & Review Guide Page 4 of 50
RN HESI Pharmacology Exam V2 Questions
& Answers, Latest Updated 2026/2027
Edition
Comprehensive Examination Question Bank • In-Depth Rationales • Concept Mapping
TOTAL QUESTIONS EXAM TOPICS RATIONALES
97 Questions 12 Modules 100% Verified
DOCUMENT OVERVIEW
This document contains 97 verified questions with correct answers and detailed rationales covering
pharmacological principles and drug interactions. It provides comprehensive insights into medication
mechanisms, side effects, and considerations for various health conditions, making it suitable for nursing
education, exam preparation, and professional certification review.
EXAM BLUEPRINT & TOPIC DISTRIBUTION
Systematic breakdown of subject domains and exam coverage.
Topic Module Scope & Core Focus Questions Share (%)
This topic covers various antihypertensive medications, their
mechanisms of action, side effects, and nursing
Antihypertensive Medications considerations. 10 Qs 10.3%
This topic focuses on short-acting and long-acting beta-2
agonists used in asthma management, including their actions
Beta-2 Agonists and patient education. 8 Qs 8.2%
This topic examines the role, mechanisms, and side effects of
ACE inhibitors in managing hypertension and other
ACE Inhibitors conditions. 8 Qs 8.2%
This topic discusses diuretics, their mechanisms of action,
Diuretics effects on electrolyte balance, and nursing implications. 8 Qs 8.2%
This topic analyzes beta-blockers, their effects on heart rate
and blood pressure, and specific considerations in different
Beta-Blockers patient populations. 8 Qs 8.2%
Confidential • Student Study Edition • Practice & Review Guide Page 1 of 50
,STUDENT STUDY & MASTERY EDITION PRACTICE & REVIEW GUIDE
This topic covers anticoagulant medications, their therapeutic
Anticoagulants uses, and the importance of monitoring laboratory values. 8 Qs 8.2%
This topic addresses antibiotic therapy, including indications,
Antibiotics side effects, and considerations for patients with allergies. 8 Qs 8.2%
This topic emphasizes safe medication administration
Medication Administration and practices and the importance of monitoring for adverse
Monitoring effects. 8 Qs 8.2%
This topic focuses on pharmacological management of
Chronic Conditions Management chronic conditions, including diabetes and heart failure. 8 Qs 8.2%
Pharmacokinetics and This topic explores the principles of pharmacokinetics and
Pharmacodynamics pharmacodynamics as they relate to drug therapy. 8 Qs 8.2%
Nursing Considerations in This topic highlights the nursing considerations necessary for
Pharmacotherapy safe pharmacotherapy and patient education. 8 Qs 8.2%
This topic addresses the management of electrolytes in
Electrolyte Management patients receiving diuretics and other medications. 7 Qs 7.2%
Total Exam Coverage 12 Integrated Topic Modules 97 Qs 100.0%
Confidential • Student Study Edition • Practice & Review Guide Page 2 of 50
,STUDENT STUDY & MASTERY EDITION PRACTICE & REVIEW GUIDE
TOPIC 1: ANTIHYPERTENSIVE MEDICATIONS
10 Questions • 10.3% of Exam • This topic covers various antihypertensive medications, their mechanisms of action, side effects, and
nursing considerations.
QUESTION 1
A 45-year-old client with hypertension is prescribed enalapril and tells the nurse that he
has been taking atenolol for 2 years. What instruction should the nurse provide
regarding the new medication?
[A] To continue taking atenolol as prescribed and start enalapril at the next scheduled dose.
[B] To stop taking atenolol as soon as enalapril starts and report any side effects.
[C] To take enalapril as directed and notify the healthcare provider if they experience any side effects from stopping
atenolol.
[D] To report to the healthcare provider that they have been taking atenolol for 2 years and ask if they should stop taking it.
Correct Answer: C. To take enalapril as directed and notify the healthcare provider if they experience any
side effects from stopping atenolol.
Rationale: The nurse should instruct the client to take enalapril as directed and report any side effects from stopping
atenolol.
QUESTION 2
A 60-year-old male client with hypertension is prescribed enalapril. What is a potential
side effect of this medication?
[A] Increased potassium levels.
[B] Decreased potassium levels.
[C] Increased sodium levels.
[D] Cough and angioedema.
Correct Answer: D. Cough and angioedema.
Rationale: Enalapril can cause cough and angioedema as a potential side effect.
Confidential • Student Study Edition • Practice & Review Guide Page 3 of 50
, STUDENT STUDY & MASTERY EDITION PRACTICE & REVIEW GUIDE
QUESTION 3
A 62-year-old male client is prescribed enalapril for hypertension. He also has a history
of chronic kidney disease (CKD). Which precaution should the nurse take when
administering enalapril?
[A] Monitor for signs of renal failure
[B] Administer with food to reduce gastrointestinal side effects
[C] Hold the medication in case of a kidney stone
[D] Increase the dose to enhance diuretic effect
Correct Answer: A. Monitor for signs of renal failure.
Rationale: Enalapril is contraindicated in clients with bilateral renal artery stenosis or unilateral stenosis in a solitary kidney.
QUESTION 4
A 55-year-old client is prescribed enalapril for hypertension. The nurse reviews the
medication list and notes that the client is currently taking atenolol. Which instruction
should the nurse provide to the client regarding the new medication?
[A] To discontinue atenolol use immediately.
[B] To gradually taper off atenolol over a 2-week period.
[C] To continue taking atenolol as prescribed and start enalapril as directed.
[D] To stop taking atenolol for 24 hours before starting enalapril.
Correct Answer: C. To continue taking atenolol as prescribed and start enalapril as directed.
Rationale: Enalapril can be initiated concurrently with atenolol without tapering.
Confidential • Student Study Edition • Practice & Review Guide Page 4 of 50
