ADVANCED PHARMOCOLGY / PRIMARY CARE EXAM /
NSG 5442 UTA WEEK 1-8 TEST BANK PAST PAPERS
Q&A WITH RATIONALES | A+ GRADED | PASS |
BRANDNEW!!!!!!!!!!!!!
Question
What is the inheritance pattern of Huntington's disease?
A) Autosomal dominant with a 50% recurrence risk for each pregnancy
B) Autosomal recessive with a 25% recurrence risk
C) X-linked recessive
D) Mitochondrial inheritance
Expert Rationale: Huntington's disease follows an autosomal dominant inheritance
pattern with a 50% recurrence risk for each pregnancy. If one parent is affected, each child
has a 50% chance of inheriting the mutated gene.
Question
What is the effect of early prenatal alcohol exposure?
A) Disrupts fetal brain development, leading to fetal alcohol spectrum disorders
B) Causes only physical deformities
C) Has no effect on the fetus
D) Only affects the mother
Expert Rationale: Early prenatal alcohol exposure disrupts fetal brain development,
leading to fetal alcohol spectrum disorders (FASD). Alcohol is a teratogen that crosses the
placenta and can cause permanent cognitive and physical defects.
Question
What is an indication for karyotype testing in newborns?
A) Ambiguous genitalia or suspected chromosomal structural abnormalities
B) Mild jaundice
,C) Feeding difficulties alone
D) Prematurity alone
Expert Rationale: Karyotype testing in newborns is indicated for ambiguous genitalia or
suspected chromosomal structural abnormalities. It helps identify chromosomal disorders
such as Turner syndrome, Klinefelter syndrome, or trisomies.
Question
What is the mechanism of feeding difficulty in a newborn with a cleft palate?
A) Inability to generate negative suction pressure required for effective nursing
B) Excessive tongue movement
C) Narrow esophagus
D) Overproduction of saliva
Expert Rationale: A newborn with a cleft palate cannot generate the negative suction
pressure required for effective nursing. The opening in the palate allows air to escape,
preventing adequate suction. Special bottles and feeding techniques are needed.
Question
What is the recurrence risk of amniotic band syndrome?
A) Low recurrence risk because it is a mechanical disruption, not genetic
B) 25% recurrence risk
C) 50% recurrence risk
D) 100% recurrence risk
Expert Rationale: Amniotic band syndrome has a low recurrence risk because it is a
mechanical disruption, not a genetic condition. It occurs when fibrous bands from the
amniotic sac entangle fetal parts, causing constriction and malformation.
Question
A couple has a child with an autosomal recessive disorder. What is the recurrence risk for
each future pregnancy?
A) 25%
B) 50%
,C) 75%
D) 100%
Expert Rationale: For autosomal recessive disorders, if both parents are carriers, the
recurrence risk for each pregnancy is 25%. There is a 50% chance the child will be a carrier
and a 25% chance the child will be unaffected.
Question
A couple has a child with an autosomal dominant disorder. What is the recurrence risk for
each future pregnancy if one parent is affected?
A) 50%
B) 25%
C) 75%
D) 100%
Expert Rationale: For autosomal dominant disorders, if one parent is affected, the
recurrence risk for each pregnancy is 50%. The affected parent has one normal allele and
one mutated allele.
Question
What is the recurrence risk for an X-linked recessive disorder if the mother is a carrier?
A) 50% of sons affected, 50% of daughters carriers
B) 100% of sons affected
C) 25% of sons affected
D) 50% of daughters affected
Expert Rationale: For X-linked recessive disorders, if the mother is a carrier, each son has
a 50% chance of being affected, and each daughter has a 50% chance of being a carrier.
Daughters are usually unaffected unless the father is also affected.
Question
What is a teratogen?
A) Any agent that can cause a birth defect or malformation
B) A type of genetic mutation
, C) A chromosomal abnormality
D) A type of inheritance pattern
Expert Rationale: A teratogen is any agent that can cause a birth defect or malformation.
Examples include alcohol, certain medications, infections, and radiation. The effect
depends on the timing, dose, and duration of exposure.
Question
What is the most critical period for teratogenic exposure?
A) The first 8 weeks of gestation (organogenesis)
B) The second trimester
C) The third trimester
D) The postpartum period
Expert Rationale: The first 8 weeks of gestation (organogenesis) is the most critical period
for teratogenic exposure. During this time, major organ systems are forming, and the fetus
is most vulnerable to malformations.
Question
What is fetal alcohol syndrome (FAS)?
A) A spectrum of disorders caused by prenatal alcohol exposure, characterized by facial
dysmorphology, growth restriction, and CNS abnormalities
B) A genetic disorder
C) A chromosomal abnormality
D) A type of autism
Expert Rationale: Fetal alcohol syndrome (FAS) is a spectrum of disorders caused by
prenatal alcohol exposure, characterized by facial dysmorphology, growth restriction, and
central nervous system abnormalities. It is the most severe form of fetal alcohol spectrum
disorders (FASD).
Question
What are the characteristic facial features of fetal alcohol syndrome?
A) Smooth philtrum, thin upper lip, small palpebral fissures
B) Large ears, thick lips, wide-set eyes