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HESI A2 Anatomy & Physiology Study Guide | A&P Practice Questions & Nursing Entrance Exam Prep 2026/2027

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Ace your HESI A2 Anatomy & Physiology preparation with this study guide designed to support effective review of essential anatomy and physiology concepts for the nursing entrance exam. Strengthen your understanding of anatomical terminology, cells and tissues, homeostasis, integumentary, skeletal, muscular, cardiovascular, respiratory, nervous, endocrine, digestive, urinary, and reproductive systems while reinforcing key physiological processes and body-system functions for 2026/2027 HESI A2 preparation.

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HESI A2 Anatomy & Physiology Study
Guide | A&P Practice Questions & Nursing
Entrance Exam Prep
2026/2027

, Which is an anterior muscle? B. An anterior muscle is located near the front of the body. Of those listed, the
A. Gluteus maximus quadriceps( frontal thigh muscle) is the most anterior.
B. Quadriceps femoris
C. Biceps femoris
D. Adductor magnus


How might the headrest on a car prevent traumatic injury? B. The headrest prevents the head from moving too far backward, or
A. By limiting hyperflexion of the neck hyperextending the neck beyond its normal range.
B. By limiting hyperextension of the neck
C. By reducing vertebral compression
D. By preventing disc degeneration


Which might you expect to see in a whiplash injury? D. Because of the hyperflexion and hyperextension caused by such a collision, it is
A. Cardiopulmonary problems not uncommon to find tears or stretching of the ligaments of the spine. The injury is
B. Side-to-side spinal curvature front-to-back, making choice B unlikely, and a herniated disc (choice C) is more of a
C. Eventual herniation of discs compression injury.
D. Traumatic injury to ligaments


Muscle contractions that normally move food along the C. Defecation(choice A) is the elimination of waste. Osmosis (choice B) is the
human digestive system are known as ________. movement of molecules across a membrane. Circulation (choice D) is the
A. defecation movement of blood through the body. Peristalsis (choice C) is the involuntary,
B. osmosis wavelike movement of muscles in the intestine and elsewhere that pushes food
C. peristalsis along.
D. circulation


Which type of nutrient does not provide the body with A. Some nutrients supply energy, and others support metabolism. Nutrients in the
energy? first set include carbohydrates, proteins, and fats. Those in the secound set include
A. Vitamin vitamins, minerals, and water.
B. Carbohydrate
C. Fat
D. Protein


Where would you be likely to find a Schwann cell? B. Schwann cells wrap around the nerve fibers and form the myelin sheath in the
A. In the digestive system peripheral nervous system.
B. In the nervous system
C. In the skeletal system
D. In the muscular system


How does the nervous system work with the muscular B. The nervous system is made up of the brain, spinal cord, and nerves. It receives
system? and transmits signals from the environment that regulate voluntary and involuntary
A. The muscles of the body produce chemicals that feed movement.
the nerves.
B. The nervous system tells the muscles how to respond to
the environment.
C. The nervous system releases chemicals that remove
excess waste from the muscles.
D. The muscular system provides input that allows the
nerves to make decisions.


Which part of the nervous system includes the femoral , A. The symphathetic and parasympathetic systems (choice C and D) are part of the
radial, and ulnar nerves? autonomic nervous system (choice B), which controls involuntary actions of the
A. Somatic smooth muscles, glands, and heart. The somatic nervous system (choice A) has to
B. Autonomic do with reception of external stimuli and voluntary control of the muscles.
C. Sympathetic
D. Parasympathetic


Where might a herniated lumbar disc be most likely to C. Damage to a disc in the lower back will most likely cause pain radiating
create pain? downward along the sciatic nerve.
A. Along the radial nerve
B. Within the spinal cord
C. Along the sciatic nerve
D. Along the tibial nerve


What is the name of the bone in the human thigh? B. The ulna (choice A), radius (choice C), and humerus (choice D) are arm bones.
A. Ulna
B. Femur
C. Radius
D. Humerus

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