1
NU 518 QUIZ 8 2026/2027 | ADVANCED
PHARMACOLOGY | 50 VERIFIED Q&A |
DETAILED RATIONALES | NGN-ALIGNED |
PASS GUARANTEED – A+ GRADED
SECTION 1: CARDIOVASCULAR PHARMACOLOGY - Questions 1-10
Q1: Inclisiran Mechanism
The student is reviewing lipid-lowering therapies. What is the mechanism of action of inclisiran?
A. Small interfering RNA that inhibits PCSK9 synthesis
B. Monoclonal antibody against PCSK9
C. Inhibits HMG-CoA reductase
D. Inhibits cholesterol absorption
Correct Answer: A
Rationale: Inclisiran is a small interfering RNA (siRNA) that targets PCSK9 mRNA, reducing PCSK9
synthesis and increasing LDL receptor availability. It is administered subcutaneously every 6 months
after initial dosing. Evolocumab and alirocumab are monoclonal antibodies against PCSK9. [100%
CORRECT]
Q2: Mavacamten Use
The student is reviewing cardiac medications. What is the primary use of mavacamten?
A. Treatment of obstructive hypertrophic cardiomyopathy
B. Treatment of heart failure with reduced ejection fraction
C. Treatment of atrial fibrillation
D. Treatment of hypertension
Correct Answer: A
Rationale: Mavacamten is a cardiac myosin inhibitor used for symptomatic obstructive hypertrophic
cardiomyopathy. It reduces myocardial contractility and improves symptoms. It requires monitoring
of left ventricular ejection fraction. [100% CORRECT]
Q3: Tafamidis Mechanism
The student is reviewing medications for amyloidosis. What is the mechanism of action of tafamidis?
A. Stabilizes transthyretin tetramers, preventing amyloid formation
B. Inhibits proteasome
,2
C. Monoclonal antibody against amyloid
D. Reduces amyloid production
Correct Answer: A
Rationale: Tafamidis is a transthyretin stabilizer that binds to transthyretin and prevents dissociation
into amyloidogenic monomers. It is used for transthyretin amyloid cardiomyopathy. [100%
CORRECT]
Q4: Vericiguat Monitoring
The student is reviewing heart failure medications. Which laboratory value should be monitored
during vericiguat therapy?
A. Hemoglobin
B. Potassium
C. Sodium
D. Calcium
Correct Answer: A
Rationale: Vericiguat can cause anemia. Hemoglobin should be monitored at baseline and
periodically. It can also cause hypotension. [100% CORRECT]
Q5: Ivabradine Phosphenes
The student is reviewing ivabradine. Which adverse effect is characterized by visual disturbances?
A. Phosphenes
B. Cataracts
C. Glaucoma
D. Macular degeneration
Correct Answer: A
Rationale: Ivabradine can cause phosphenes, which are visual disturbances described as increased
brightness or light perception. They are usually transient and resolve with continued therapy. [100%
CORRECT]
Q6: Sacubitril/Valsartan Angioedema
The student is reviewing sacubitril/valsartan. Which serious adverse effect requires immediate
discontinuation?
A. Angioedema
B. Hypertension
C. Bradycardia
D. Hyperglycemia
Correct Answer: A
, 3
Rationale: Sacubitril/valsartan can cause angioedema, especially in patients with a history of ACE
inhibitor-induced angioedema. It should be discontinued immediately if angioedema occurs. [100%
CORRECT]
Q7: SGLT2 Inhibitor Euglycemic DKA
The student is reviewing SGLT2 inhibitors. Which serious adverse effect can occur even with normal
blood glucose levels?
A. Euglycemic diabetic ketoacidosis
B. Hyperglycemic hyperosmolar state
C. Hypoglycemia
D. Hypertension
Correct Answer: A
Rationale: SGLT2 inhibitors can cause euglycemic diabetic ketoacidosis, where ketoacidosis occurs
without significantly elevated blood glucose. Patients should be monitored for nausea, vomiting,
abdominal pain, and acidosis. [100% CORRECT]
Q8: PCSK9 Inhibitor Administration
The student is reviewing PCSK9 inhibitors. How are evolocumab and alirocumab administered?
A. Subcutaneously
B. Orally
C. Intravenously
D. Intramuscularly
Correct Answer: A
Rationale: PCSK9 inhibitors are monoclonal antibodies administered subcutaneously every 2 or 4
weeks. They are used for familial hypercholesterolemia and statin-intolerant patients. [100%
CORRECT]
Q9: Bempedoic Acid Tendon Rupture
The student is reviewing bempedoic acid. Which adverse effect should patients report immediately?
A. Tendon pain or rupture
B. Dry cough
C. Peripheral edema
D. Bradycardia
Correct Answer: A
Rationale: Bempedoic acid can cause tendon rupture, especially in older adults and those taking
corticosteroids or fluoroquinolones. Patients should report tendon pain immediately. [100%
CORRECT]
NU 518 QUIZ 8 2026/2027 | ADVANCED
PHARMACOLOGY | 50 VERIFIED Q&A |
DETAILED RATIONALES | NGN-ALIGNED |
PASS GUARANTEED – A+ GRADED
SECTION 1: CARDIOVASCULAR PHARMACOLOGY - Questions 1-10
Q1: Inclisiran Mechanism
The student is reviewing lipid-lowering therapies. What is the mechanism of action of inclisiran?
A. Small interfering RNA that inhibits PCSK9 synthesis
B. Monoclonal antibody against PCSK9
C. Inhibits HMG-CoA reductase
D. Inhibits cholesterol absorption
Correct Answer: A
Rationale: Inclisiran is a small interfering RNA (siRNA) that targets PCSK9 mRNA, reducing PCSK9
synthesis and increasing LDL receptor availability. It is administered subcutaneously every 6 months
after initial dosing. Evolocumab and alirocumab are monoclonal antibodies against PCSK9. [100%
CORRECT]
Q2: Mavacamten Use
The student is reviewing cardiac medications. What is the primary use of mavacamten?
A. Treatment of obstructive hypertrophic cardiomyopathy
B. Treatment of heart failure with reduced ejection fraction
C. Treatment of atrial fibrillation
D. Treatment of hypertension
Correct Answer: A
Rationale: Mavacamten is a cardiac myosin inhibitor used for symptomatic obstructive hypertrophic
cardiomyopathy. It reduces myocardial contractility and improves symptoms. It requires monitoring
of left ventricular ejection fraction. [100% CORRECT]
Q3: Tafamidis Mechanism
The student is reviewing medications for amyloidosis. What is the mechanism of action of tafamidis?
A. Stabilizes transthyretin tetramers, preventing amyloid formation
B. Inhibits proteasome
,2
C. Monoclonal antibody against amyloid
D. Reduces amyloid production
Correct Answer: A
Rationale: Tafamidis is a transthyretin stabilizer that binds to transthyretin and prevents dissociation
into amyloidogenic monomers. It is used for transthyretin amyloid cardiomyopathy. [100%
CORRECT]
Q4: Vericiguat Monitoring
The student is reviewing heart failure medications. Which laboratory value should be monitored
during vericiguat therapy?
A. Hemoglobin
B. Potassium
C. Sodium
D. Calcium
Correct Answer: A
Rationale: Vericiguat can cause anemia. Hemoglobin should be monitored at baseline and
periodically. It can also cause hypotension. [100% CORRECT]
Q5: Ivabradine Phosphenes
The student is reviewing ivabradine. Which adverse effect is characterized by visual disturbances?
A. Phosphenes
B. Cataracts
C. Glaucoma
D. Macular degeneration
Correct Answer: A
Rationale: Ivabradine can cause phosphenes, which are visual disturbances described as increased
brightness or light perception. They are usually transient and resolve with continued therapy. [100%
CORRECT]
Q6: Sacubitril/Valsartan Angioedema
The student is reviewing sacubitril/valsartan. Which serious adverse effect requires immediate
discontinuation?
A. Angioedema
B. Hypertension
C. Bradycardia
D. Hyperglycemia
Correct Answer: A
, 3
Rationale: Sacubitril/valsartan can cause angioedema, especially in patients with a history of ACE
inhibitor-induced angioedema. It should be discontinued immediately if angioedema occurs. [100%
CORRECT]
Q7: SGLT2 Inhibitor Euglycemic DKA
The student is reviewing SGLT2 inhibitors. Which serious adverse effect can occur even with normal
blood glucose levels?
A. Euglycemic diabetic ketoacidosis
B. Hyperglycemic hyperosmolar state
C. Hypoglycemia
D. Hypertension
Correct Answer: A
Rationale: SGLT2 inhibitors can cause euglycemic diabetic ketoacidosis, where ketoacidosis occurs
without significantly elevated blood glucose. Patients should be monitored for nausea, vomiting,
abdominal pain, and acidosis. [100% CORRECT]
Q8: PCSK9 Inhibitor Administration
The student is reviewing PCSK9 inhibitors. How are evolocumab and alirocumab administered?
A. Subcutaneously
B. Orally
C. Intravenously
D. Intramuscularly
Correct Answer: A
Rationale: PCSK9 inhibitors are monoclonal antibodies administered subcutaneously every 2 or 4
weeks. They are used for familial hypercholesterolemia and statin-intolerant patients. [100%
CORRECT]
Q9: Bempedoic Acid Tendon Rupture
The student is reviewing bempedoic acid. Which adverse effect should patients report immediately?
A. Tendon pain or rupture
B. Dry cough
C. Peripheral edema
D. Bradycardia
Correct Answer: A
Rationale: Bempedoic acid can cause tendon rupture, especially in older adults and those taking
corticosteroids or fluoroquinolones. Patients should report tendon pain immediately. [100%
CORRECT]
