Page 1 of 90
COMSAE EXAM PREP NEWEST 2026 ACTUAL
EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) ALL
ANSWERED {150 Q & A} ALREADY GRADED A+ |
BRAND NEW! | 100% GUARANTEED PASS
✅ A 22-year-old woman presents to the office for evaluation of
malaise and easy bruising. She also reports increased menses
over the past 2 months. Review of records reveals a hospital
admission 6 months ago secondary to viral pneumonia. Physical
examination findings are normal. Laboratory study results are
normal except for a platelet count of 45 × 103/mcL (reference
range: 150-450 × 103/mcL). The most likely diagnosis is
A. factor VII deficiency
B. IgA vasculitis (Henoch-Schönlein purpura)
C. idiopathic thrombocytopenic purpura
D. thrombotic thrombocytopenic purpura
E. von Willebrand disease - ✔✔✔ Correct Answer > C. IDIOPATHIC
THROMBOCYTOPENIC PURPURA (ITP)
An acquired form of a low platelet count secondary to antibody
formation against GpIIb/IIIa on platelets, without any perturbation
of the structure or function of WBCs, RBCs, or coagulation
factors (i.e., isolated thrombocytopenia). It is a diagnosis of
exclusion without specific clinical or laboratory parameters.
,Page 2 of 90
✅ A 21-year-old woman presents to the office with a 6-month
history of increasing low back pain. She reports that she
competes as a figure skater, and the pain began following a bad
landing. She describes the pain as achy and localized to the
lumbosacral junction. A radiograph of the spine taken 1 month
ago reveals the findings shown in the exhibit. Neurologic
examination findings are normal, with no focal motor deficits.
Structural examination reveals increased tone in the lumbar
paravertebral muscles with midline tenderness in the
lumbosacral area. Which of the following injuries did this patient
most likely sustain?
A. acute L3 flexion somatic dysfunction
B .acute right unilateral sacral flexion
C. fracture of the L5 pars interarticularis
D. L5 vertebral compression fracture
E. muscle strain of the quadratus lumborum - ✔✔✔ Correct Answer >
C. FRACTURE OF THE L5 PARS INTERARTICULARIS
,Page 3 of 90
✅ A male neonate is evaluated in the labor and delivery room
immediately after delivery for tachypnea and room air hypoxia.
The patient was delivered via cesarean section due to fetal
tachycardia and non-reassuring fetal heart tones. The mother
had limited prenatal care. Vital signs reveal a respiratory rate of
80-100/min. Physical examination reveals intercostal and
subcostal retractions and nasal flaring. The abdomen appears
scaphoid. Chest auscultation reveals decreased lung sounds on
the left and a right shift of heart sounds. The most appropriate
diagnostic test is
A. arterial blood gas analysis
B. chest radiography
C. echocardiography
D. fluoroscopy
E. oxygen challenge test - ✔✔✔ Correct Answer > B. CHEST
RADIOGRAPHY
The clinical scenario describes a neonate w/respiratory distress
immediately after birth, w/ signs including tachypnea, nasal
flaring, intercostal and subcostal retractions, decreased lung
sounds on the left, and a rightward shift of the heart sounds. The
scaphoid abdomen is particularly concerning for congenital
diaphragmatic hernia (CDH), a condition where abdominal
contents herniate into the chest, leading to lung hypoplasia and
displacement of the heart and mediastinum.
Chest radiography is the most appropriate diagnostic test to
confirm the diagnosis by visualizing the herniated abdominal
organs within the chest cavity. Other options, such as arterial
blood gas analysis or echocardiography, do not provide the
immediate anatomical information needed in this scenario.
, Page 4 of 90
A 53-year-old man is brought to the office by a staff member
from the group home where he has resided for the past 4 years.
The staff member reports that the patient has a 1-year history of
gradually worsening mouth and tongue movements. The
movements are not apparent when he is sleeping. Past medical
history reveals chronic schizophrenia, which has been treated
with long-acting injectable antipsychotics for approximately 25
years. He has no other known neurologic history. His only
current medication is fluphenazine decanoate. Physical
examination reveals thrusting movements of the tongue to the
left and frequent grimacing that can be partially controlled by the
patient but is exacerbated when he is distracted. The most
appropriate treatment is to slowly taper fluphenazine and start
A. carbidopa-levodopa
B. clozapine
C. dantrolene
D. phenytoin
E. tizanidine - ✔✔✔ Correct Answer > B. CLOZAPINE
An atypical antipsychotic mainly used for treatment-resistant
schizophrenia that has a ↓ risk of extrapyramidal symptoms
compared to typical antipsychotics. Its most dangerous adverse
effect is life-threatening agranulocytosis; as a result, frequent
blood testing is required after initiating treatment.
A 28-year-old man presents to the office with a 14-day history of
sore throat, foul taste in his mouth, and heartburn. Past medical
history reveals hemophilia and a transfusion reaction 15 years
ago. The patient's temperature is 36.9°C (98.4°F). Physical
examination reveals cervical lymphadenopathy and thick white
exudate on the oropharynx and tongue. Scraping of the exudate
causes punctate mucosal bleeding. This patient's pharyngeal
exudate is most likely due to
A. bacterial pharyngitis
COMSAE EXAM PREP NEWEST 2026 ACTUAL
EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) ALL
ANSWERED {150 Q & A} ALREADY GRADED A+ |
BRAND NEW! | 100% GUARANTEED PASS
✅ A 22-year-old woman presents to the office for evaluation of
malaise and easy bruising. She also reports increased menses
over the past 2 months. Review of records reveals a hospital
admission 6 months ago secondary to viral pneumonia. Physical
examination findings are normal. Laboratory study results are
normal except for a platelet count of 45 × 103/mcL (reference
range: 150-450 × 103/mcL). The most likely diagnosis is
A. factor VII deficiency
B. IgA vasculitis (Henoch-Schönlein purpura)
C. idiopathic thrombocytopenic purpura
D. thrombotic thrombocytopenic purpura
E. von Willebrand disease - ✔✔✔ Correct Answer > C. IDIOPATHIC
THROMBOCYTOPENIC PURPURA (ITP)
An acquired form of a low platelet count secondary to antibody
formation against GpIIb/IIIa on platelets, without any perturbation
of the structure or function of WBCs, RBCs, or coagulation
factors (i.e., isolated thrombocytopenia). It is a diagnosis of
exclusion without specific clinical or laboratory parameters.
,Page 2 of 90
✅ A 21-year-old woman presents to the office with a 6-month
history of increasing low back pain. She reports that she
competes as a figure skater, and the pain began following a bad
landing. She describes the pain as achy and localized to the
lumbosacral junction. A radiograph of the spine taken 1 month
ago reveals the findings shown in the exhibit. Neurologic
examination findings are normal, with no focal motor deficits.
Structural examination reveals increased tone in the lumbar
paravertebral muscles with midline tenderness in the
lumbosacral area. Which of the following injuries did this patient
most likely sustain?
A. acute L3 flexion somatic dysfunction
B .acute right unilateral sacral flexion
C. fracture of the L5 pars interarticularis
D. L5 vertebral compression fracture
E. muscle strain of the quadratus lumborum - ✔✔✔ Correct Answer >
C. FRACTURE OF THE L5 PARS INTERARTICULARIS
,Page 3 of 90
✅ A male neonate is evaluated in the labor and delivery room
immediately after delivery for tachypnea and room air hypoxia.
The patient was delivered via cesarean section due to fetal
tachycardia and non-reassuring fetal heart tones. The mother
had limited prenatal care. Vital signs reveal a respiratory rate of
80-100/min. Physical examination reveals intercostal and
subcostal retractions and nasal flaring. The abdomen appears
scaphoid. Chest auscultation reveals decreased lung sounds on
the left and a right shift of heart sounds. The most appropriate
diagnostic test is
A. arterial blood gas analysis
B. chest radiography
C. echocardiography
D. fluoroscopy
E. oxygen challenge test - ✔✔✔ Correct Answer > B. CHEST
RADIOGRAPHY
The clinical scenario describes a neonate w/respiratory distress
immediately after birth, w/ signs including tachypnea, nasal
flaring, intercostal and subcostal retractions, decreased lung
sounds on the left, and a rightward shift of the heart sounds. The
scaphoid abdomen is particularly concerning for congenital
diaphragmatic hernia (CDH), a condition where abdominal
contents herniate into the chest, leading to lung hypoplasia and
displacement of the heart and mediastinum.
Chest radiography is the most appropriate diagnostic test to
confirm the diagnosis by visualizing the herniated abdominal
organs within the chest cavity. Other options, such as arterial
blood gas analysis or echocardiography, do not provide the
immediate anatomical information needed in this scenario.
, Page 4 of 90
A 53-year-old man is brought to the office by a staff member
from the group home where he has resided for the past 4 years.
The staff member reports that the patient has a 1-year history of
gradually worsening mouth and tongue movements. The
movements are not apparent when he is sleeping. Past medical
history reveals chronic schizophrenia, which has been treated
with long-acting injectable antipsychotics for approximately 25
years. He has no other known neurologic history. His only
current medication is fluphenazine decanoate. Physical
examination reveals thrusting movements of the tongue to the
left and frequent grimacing that can be partially controlled by the
patient but is exacerbated when he is distracted. The most
appropriate treatment is to slowly taper fluphenazine and start
A. carbidopa-levodopa
B. clozapine
C. dantrolene
D. phenytoin
E. tizanidine - ✔✔✔ Correct Answer > B. CLOZAPINE
An atypical antipsychotic mainly used for treatment-resistant
schizophrenia that has a ↓ risk of extrapyramidal symptoms
compared to typical antipsychotics. Its most dangerous adverse
effect is life-threatening agranulocytosis; as a result, frequent
blood testing is required after initiating treatment.
A 28-year-old man presents to the office with a 14-day history of
sore throat, foul taste in his mouth, and heartburn. Past medical
history reveals hemophilia and a transfusion reaction 15 years
ago. The patient's temperature is 36.9°C (98.4°F). Physical
examination reveals cervical lymphadenopathy and thick white
exudate on the oropharynx and tongue. Scraping of the exudate
causes punctate mucosal bleeding. This patient's pharyngeal
exudate is most likely due to
A. bacterial pharyngitis
