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Lecture 1: Cell Types and the Central Dogma
1) Prokaryotes (bacteria and archaea) are characterized by which of the following?
A) DNA contained in a membrane-bound nucleus
B) Transcription and translation occurring simultaneously
C) Transcription in the nucleus and translation in the cytoplasm
D) Lack of ribosomes
Correct Answer: B
Prokaryotes have no nucleus, their DNA is in direct contact with the cytoplasm, and
transcription and translation occur simultaneously in the same compartment .
2) In eukaryotes, transcription and translation do NOT occur simultaneously because:
A) Eukaryotes lack ribosomes
B) Transcription occurs in the nucleus and translation occurs in the cytoplasm
C) Eukaryotic DNA is single-stranded
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, D) Eukaryotes have no RNA polymerase
Correct Answer: B
DNA is contained in a membrane-bound nucleus. Transcription occurs in the nucleus,
mRNA is exported to the cytoplasm, and translation occurs there .
3) The Universal Tree of Life is based on comparisons of:
A) DNA polymerase genes
B) 16S/18S small ribosomal subunit RNA
C) Nuclear pore protein sequences
D) Mitochondrial DNA
Correct Answer: B
Carl Woese showed that all life falls into three domains (Bacteria, Archaea, Eucarya) based
on DNA sequence comparison of the gene encoding 16s/18s small ribosomal subunit .
4) The Central Dogma of Molecular Biology states that:
A) Protein makes RNA, and RNA makes DNA
B) DNA makes RNA, and RNA makes Protein
C) RNA makes DNA, and DNA makes Protein
D) Protein makes DNA, and DNA makes RNA
Correct Answer: B
The Central Dogma describes the flow of genetic information: DNA → RNA → Protein.
Reverse transcription (RNA → DNA) is an exception .
5) Catabolism is best defined as:
A) Synthesizing components of cells so they can grow and divide
B) Breaking down food to make energy
C) The sum of all chemical reactions in the cell
D) Protein synthesis
Correct Answer: B
Catabolism involves breaking down food to make energy, while anabolism synthesizes
cellular components for growth and division .
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