USMLE step -1 Immunologytony_a_Martinez
Study online at https://quizlet.com/_2sz5ug
1. Immune system -innate (or native or natural)
-adaptive (or acquired or specific)
2. Innate immunity • Present intrinsically
• Nonspecific
• No memory
• Limited diversity
3. Native immunity • Anatomic or physical (skin, mucous membranes)
• Physiologic (temperature, pH, and chemicals such as lysozyme, complement,
and some interferons)
• Phagocytic (monocytes, neutrophils, macrophages)
• Inflammatory events
4. Adaptive immu- • Lymphocytes (T cells and B cells) and plasma cells (end cells of B-lymphocyte
nity components differentiation)
• Antigen-presenting cells (macrophages, B cells, and dendritic cells)
5. Adaptive immu- • Inducible
nity • Specific
• Memory
• Extensive diversity
• Self versus non-self distinction
• Self-limiting
6. Phagocytic cells process and display antigen to facilitate stimulation of specific T lymphocytes.
7. Macrophages secrete immunoregulatory molecules (cytokines), which help trigger the initiation
of specific immune responses.
, USMLE step -1 Immunologytony_a_Martinez
Study online at https://quizlet.com/_2sz5ug
8. T lymphocytes produce cytokines, which enhance the microbicidal activities of phagocytes.
9. Antibodies pro- -plasma cells
duced by ..... bind -complement system
to pathogens
and activate the
.... to result in
the destruction
of the invaders
10. lymphoid prog- makes B cells, T cells, and NK cells.
enitor
11. myeloid progeni- makes red blood cells, platelets, basophils, mast
tor cells, eosinophils, neutrophils, monocytes,
macrophages, and dendritic cells
12. Monocyte -Kidney bean-shaped nucleus, CD14 positive
-Bloodstream, 0-900/μL
-Phagocytic, differentiate into tissue macrophages
, USMLE step -1 Immunologytony_a_Martinez
Study online at https://quizlet.com/_2sz5ug
13. Macrophage -Tissues
-Ruffled membrane, cytoplasm with vacuoles and vesicles, CD14 positive
-Phagocytosis,secretion of cytokines
14. Dendritic cell -Epithelia, tissues
-Long cytoplasmic arms
-Antigen capture, transport, and presentation
-agitate the immune system constantly==> memory
15. Neutrophil -Bloodstream, 1,800-7,800/μL
-Multilobednucleus; small light pink to purple
granules
-Phagocytosis and activation of bactericidal mechanisms
, USMLE step -1 Immunologytony_a_Martinez
Study online at https://quizlet.com/_2sz5ug
16. Eosinophil -Bloodstream, 0-450/μL
-Bilobed nucleus, large pink granules
-Killing of antibody-coated parasites
17. Myeloid cells are innate branch
in the .....?
18. Lymphoid cells Natural killer cells
are in the adap-
tive branch ex-
cept.......
19. Basophil -Bloodstream, 0-200/μL
-Bilobed nucleus, large blue granules
-Nonphagocytic, release pharmacologically active substances during allergic re-
sponses
20. Mast cell -Tissues, mucosa, and epithelia
-Small nucleus, cytoplasm packed with large blue granules
-Release of granules containing histamine, etc., during allergic responses
21. Lymphocyte -Bloodstream ,1,000-4,000/μl; lymph nodes,
spleen, submucosa, and epithelia
-Large, dark nucleus, small rim of cytoplasm
B cells - CD19,20,21
T cells - CD3
TH cells -CD4
CTLs - CD8
Study online at https://quizlet.com/_2sz5ug
1. Immune system -innate (or native or natural)
-adaptive (or acquired or specific)
2. Innate immunity • Present intrinsically
• Nonspecific
• No memory
• Limited diversity
3. Native immunity • Anatomic or physical (skin, mucous membranes)
• Physiologic (temperature, pH, and chemicals such as lysozyme, complement,
and some interferons)
• Phagocytic (monocytes, neutrophils, macrophages)
• Inflammatory events
4. Adaptive immu- • Lymphocytes (T cells and B cells) and plasma cells (end cells of B-lymphocyte
nity components differentiation)
• Antigen-presenting cells (macrophages, B cells, and dendritic cells)
5. Adaptive immu- • Inducible
nity • Specific
• Memory
• Extensive diversity
• Self versus non-self distinction
• Self-limiting
6. Phagocytic cells process and display antigen to facilitate stimulation of specific T lymphocytes.
7. Macrophages secrete immunoregulatory molecules (cytokines), which help trigger the initiation
of specific immune responses.
, USMLE step -1 Immunologytony_a_Martinez
Study online at https://quizlet.com/_2sz5ug
8. T lymphocytes produce cytokines, which enhance the microbicidal activities of phagocytes.
9. Antibodies pro- -plasma cells
duced by ..... bind -complement system
to pathogens
and activate the
.... to result in
the destruction
of the invaders
10. lymphoid prog- makes B cells, T cells, and NK cells.
enitor
11. myeloid progeni- makes red blood cells, platelets, basophils, mast
tor cells, eosinophils, neutrophils, monocytes,
macrophages, and dendritic cells
12. Monocyte -Kidney bean-shaped nucleus, CD14 positive
-Bloodstream, 0-900/μL
-Phagocytic, differentiate into tissue macrophages
, USMLE step -1 Immunologytony_a_Martinez
Study online at https://quizlet.com/_2sz5ug
13. Macrophage -Tissues
-Ruffled membrane, cytoplasm with vacuoles and vesicles, CD14 positive
-Phagocytosis,secretion of cytokines
14. Dendritic cell -Epithelia, tissues
-Long cytoplasmic arms
-Antigen capture, transport, and presentation
-agitate the immune system constantly==> memory
15. Neutrophil -Bloodstream, 1,800-7,800/μL
-Multilobednucleus; small light pink to purple
granules
-Phagocytosis and activation of bactericidal mechanisms
, USMLE step -1 Immunologytony_a_Martinez
Study online at https://quizlet.com/_2sz5ug
16. Eosinophil -Bloodstream, 0-450/μL
-Bilobed nucleus, large pink granules
-Killing of antibody-coated parasites
17. Myeloid cells are innate branch
in the .....?
18. Lymphoid cells Natural killer cells
are in the adap-
tive branch ex-
cept.......
19. Basophil -Bloodstream, 0-200/μL
-Bilobed nucleus, large blue granules
-Nonphagocytic, release pharmacologically active substances during allergic re-
sponses
20. Mast cell -Tissues, mucosa, and epithelia
-Small nucleus, cytoplasm packed with large blue granules
-Release of granules containing histamine, etc., during allergic responses
21. Lymphocyte -Bloodstream ,1,000-4,000/μl; lymph nodes,
spleen, submucosa, and epithelia
-Large, dark nucleus, small rim of cytoplasm
B cells - CD19,20,21
T cells - CD3
TH cells -CD4
CTLs - CD8
