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NCLEX-RN Comprehensive Practice Examination 2026/2027 | 200 Practice Questions with Answers & Detailed Rationales

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Prepare for the NCLEX-RN Comprehensive Practice Examination 2026/2027 with a comprehensive 200-question original practice examination featuring four multiple-choice options, correct answers, and detailed rationales. This study resource reviews major NCLEX-RN content areas, including management of care, safety and infection control, health promotion, psychosocial integrity, basic care and comfort, pharmacological therapies, reduction of risk potential, and physiological adaptation. Questions emphasize clinical judgment, prioritization, delegation, patient safety, evidence-based nursing care, and application to realistic clinical scenarios.

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NCLEX-RN Comprehensive Practice Examination

Questions 1–200 | Four Multiple-Choice Options | Correct Answers
Italicized 2026/2027




1. A nurse is assessing a client who has developed sudden shortness
of breath and chest pain. Which action should the nurse take first?

A. Obtain a complete medical history
B. Encourage the client to ambulate
C. Assess the client’s airway and breathing
D. Offer oral fluids

2. A client receiving an opioid analgesic becomes difficult to arouse
and has a respiratory rate of 8/min. Which medication should the
nurse anticipate administering?

A. Flumazenil
B. Atropine
C. Protamine sulfate
D. Naloxone

3. A nurse is caring for a client with hypoglycemia who is awake and
able to swallow. Which intervention is most appropriate?

,A. Administer regular insulin
B. Give 15 g of rapid-acting carbohydrate
C. Restrict oral intake
D. Administer potassium chloride

4. Which finding in a client receiving a blood transfusion requires the
nurse to stop the transfusion immediately?

A. Mild hunger
B. Temperature of 37°C (98.6°F)
C. Chills and sudden back pain
D. Heart rate of 72/min

5. A nurse is teaching a client taking warfarin. Which statement
indicates correct understanding?

A. “I should avoid all foods containing vitamin K.”
B. “I can double my dose if I miss one.”
C. “I should keep my vitamin K intake consistent.”
D. “I do not need laboratory monitoring.”

6. A client with heart failure has increasing dyspnea, crackles, and
oxygen saturation of 88%. Which action should the nurse take first?

A. Place the client flat
B. Encourage increased oral fluids
C. Position the client upright and administer oxygen as prescribed
D. Encourage strenuous activity

,7. Which assessment finding is most consistent with hypokalemia?

A. Peaked T waves
B. Hyperactive reflexes
C. Muscle weakness and dysrhythmias
D. Severe hypertension

8. A client with chronic obstructive pulmonary disease is receiving
oxygen. Which prescription should the nurse question?

A. Monitor oxygen saturation
B. Encourage controlled breathing
C. Apply oxygen at a high flow rate without further assessment
D. Position the client to facilitate breathing

9. A nurse is assessing a client with suspected stroke. Which finding
is most concerning?

A. Mild headache for several days
B. Sudden unilateral weakness and difficulty speaking
C. Increased appetite
D. Gradual weight gain

10. Which intervention is appropriate for a client at high risk for falls?

A. Keep the bed in the highest position
B. Place frequently used items out of reach
C. Keep the bed low and the call light within reach
D. Encourage the client to walk without assistance

, 11. A nurse is caring for a client with neutropenia. Which
intervention is appropriate?

A. Place fresh flowers in the room
B. Encourage visitors with respiratory infections
C. Perform meticulous hand hygiene and limit infection exposure
D. Serve raw foods routinely

12. A client with severe dehydration is hypotensive and tachycardic.
Which prescription should the nurse anticipate?

A. Fluid restriction
B. Isotonic IV fluid replacement
C. Potassium restriction only
D. Diuretic therapy

13. Which finding should the nurse expect in a client experiencing
anaphylaxis?

A. Bradycardia and hypertension
B. Wheezing and difficulty breathing
C. Increased urine output
D. Warm, dry skin without respiratory symptoms

14. A client receiving heparin develops bleeding gums and
hematuria. What should the nurse do first?

A. Administer the next dose
B. Encourage vigorous brushing

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