G A L E N C O L L E G E O F N U R S I N G · A S S O C I AT E D E G R E E N U R S I N G P R O G R A M
NSG 3100 Exam 3
Medication
Administration & Lab
Values
NCLEX-Style Practice Questions with Rationales
Topic Focus: Pharmacology, Medication Administration, & Diagnostic Lab
Values
Edition 1 · July 2026 · 77 Questions
Table of Contents
1. Instructions for Use 2
2. Practice Questions with Answers & Rationales — Medication Administration & Lab Values 2
NSG 3100 · Galen College of Nursing Page 1
,NSG 3100 EXAM 3 PRACTICE GUIDE INSTRUCTIONS & PRACTICE QUESTIONS
How to Use This Guide
Read each stem, choose your answer, then check the rationale directly below it. The correct
option is marked, and each wrong option is explained so you understand why it's wrong — not
just that it is. Items marked NEEDS RATIONALE had limited source detail; treat those as flags
for independent review.
Category: Pharmacology, Medication Administration, & Diagnostic Lab
Values
1 How many times must the RN check a medication before administration?
A 3 times
B 2 times
C 1 time
D 4 times
CORRECT ANSWER: A
Rationale:
The RN must check the medication 3 times: upon removing from/getting from the dispenser,
while preparing the medication, and before returning to storage or giving to the patient. This is
a critical safety measure.
Tested Concept: RN medication checks — 3 times
,2 Which factors can affect medication action? (Select all that apply)
A Developmental and gender factors
B Diet and environment
C Psychological factors
D Illness/disease
E Time of administration
F Cultural, ethnic, and religious factors
CORRECT ANSWER: A, B, C, D, E, F
Rationale:
All of these factors can affect medication action: developmental stage, gender, diet,
environment, psychological factors, illness/disease, time of administration, and cultural, ethnic,
and religious factors.
Tested Concept: Factors affecting medication action
3 Which age-related factors can affect medication action in older adults? (Select all
that apply)
A Altered memory and visual acuity
B Manual dexterity changes
C Renal and liver impairment
D Organ sensitivity
E Increased fat proportion
CORRECT ANSWER: A, B, C, D, E
Rationale:
All of these age-related factors can affect medication action in older adults. Increased fat
proportion can lead to increased fat-soluble drug toxicity.
Tested Concept: Age-related factors affecting medication action
, 4 Who is ultimately responsible for their own actions when administering
medication?
A The RN
B The LPN
C The healthcare provider
D The pharmacist
CORRECT ANSWER: A
Rationale:
The RN is responsible for their own actions when administering medication. The nurse must use
clinical judgment and follow the rights of medication administration.
Tested Concept: RN responsibility for medication administration
5 A nurse is preparing to administer a medication and is unfamiliar with it. What
should the nurse do?
A Do not administer; look up the medication and know why it is being administered
B Administer the medication and research it later
C Ask the patient if they have taken it before
D Administer half the dose to be safe
CORRECT ANSWER: A
Rationale:
If a nurse is unfamiliar with a medication, they should not administer it. The nurse must look up
the medication and understand why it is being administered before giving it.
Tested Concept: If unfamiliar with medication — do not administer
NSG 3100 Exam 3
Medication
Administration & Lab
Values
NCLEX-Style Practice Questions with Rationales
Topic Focus: Pharmacology, Medication Administration, & Diagnostic Lab
Values
Edition 1 · July 2026 · 77 Questions
Table of Contents
1. Instructions for Use 2
2. Practice Questions with Answers & Rationales — Medication Administration & Lab Values 2
NSG 3100 · Galen College of Nursing Page 1
,NSG 3100 EXAM 3 PRACTICE GUIDE INSTRUCTIONS & PRACTICE QUESTIONS
How to Use This Guide
Read each stem, choose your answer, then check the rationale directly below it. The correct
option is marked, and each wrong option is explained so you understand why it's wrong — not
just that it is. Items marked NEEDS RATIONALE had limited source detail; treat those as flags
for independent review.
Category: Pharmacology, Medication Administration, & Diagnostic Lab
Values
1 How many times must the RN check a medication before administration?
A 3 times
B 2 times
C 1 time
D 4 times
CORRECT ANSWER: A
Rationale:
The RN must check the medication 3 times: upon removing from/getting from the dispenser,
while preparing the medication, and before returning to storage or giving to the patient. This is
a critical safety measure.
Tested Concept: RN medication checks — 3 times
,2 Which factors can affect medication action? (Select all that apply)
A Developmental and gender factors
B Diet and environment
C Psychological factors
D Illness/disease
E Time of administration
F Cultural, ethnic, and religious factors
CORRECT ANSWER: A, B, C, D, E, F
Rationale:
All of these factors can affect medication action: developmental stage, gender, diet,
environment, psychological factors, illness/disease, time of administration, and cultural, ethnic,
and religious factors.
Tested Concept: Factors affecting medication action
3 Which age-related factors can affect medication action in older adults? (Select all
that apply)
A Altered memory and visual acuity
B Manual dexterity changes
C Renal and liver impairment
D Organ sensitivity
E Increased fat proportion
CORRECT ANSWER: A, B, C, D, E
Rationale:
All of these age-related factors can affect medication action in older adults. Increased fat
proportion can lead to increased fat-soluble drug toxicity.
Tested Concept: Age-related factors affecting medication action
, 4 Who is ultimately responsible for their own actions when administering
medication?
A The RN
B The LPN
C The healthcare provider
D The pharmacist
CORRECT ANSWER: A
Rationale:
The RN is responsible for their own actions when administering medication. The nurse must use
clinical judgment and follow the rights of medication administration.
Tested Concept: RN responsibility for medication administration
5 A nurse is preparing to administer a medication and is unfamiliar with it. What
should the nurse do?
A Do not administer; look up the medication and know why it is being administered
B Administer the medication and research it later
C Ask the patient if they have taken it before
D Administer half the dose to be safe
CORRECT ANSWER: A
Rationale:
If a nurse is unfamiliar with a medication, they should not administer it. The nurse must look up
the medication and understand why it is being administered before giving it.
Tested Concept: If unfamiliar with medication — do not administer
