HESI / Elsevier | Medical-Surgical Nursing Comprehensive Examination
HESI Medical-Surgical Nursing
Comprehensive Examination 2026/2027 |
Verified Questions
HESI / Elsevier | Medical-Surgical Nursing Comprehensive Examination | University-Level Nursing
Students
55 Verified Questions | 4 Core Domains | Academic Year 2026/2027
Prepared by
HESI / Elsevier | Medical-Surgical Nursing Comprehensive Examination
Comprehensive Proctored Examination Actual Exam | Academic Year 2026/2027
HESI Medical-Surgical Nursing Comprehensive Examination 2026/2027 | Verified Questions
, INTRODUCTION
This comprehensive examination contains 55 verified questions designed to reinforce the official HESI
Medical-Surgical Nursing Comprehensive Examination course objectives for the Comprehensive
Proctored Examination. The questions are organized across four core domains: Cardiovascular and
Respiratory Disorders; Gastrointestinal and Renal Disorders; Neurological and Musculoskeletal
Disorders; and Endocrine, Hematologic, and Oncologic Disorders. Content is original and aligned to the
2026/2027 academic year, emphasizing clinical reasoning and foundational medical-surgical nursing
knowledge required for actual exam readiness and clinical proficiency.
ACTUAL QUESTIONS
Domain 1: Cardiovascular and Respiratory Disorders
Question 1. A client with acute coronary syndrome reports crushing chest pain. Which
laboratory value is most specific for myocardial injury?
A. Elevated cardiac troponin
B. Elevated CK only
C. Elevated BNP exclusively
D. Elevated D-dimer
Correct Answer: A
Rationale: Cardiac troponin is the preferred biomarker for detecting myocardial injury because of its
high sensitivity and specificity for cardiac muscle damage.
Question 2. Which ECG finding is most consistent with an acute ST-elevation myocardial
infarction?
A. Prolonged PR interval
B. Isolated U waves
C. ST-segment elevation in contiguous leads
D. Narrow QRS complexes only
Correct Answer: C
Rationale: ST-segment elevation in two or more contiguous leads indicates acute myocardial injury and
guides decisions about emergent reperfusion therapy.
Question 3. A client post-PCI develops sudden hypotension, muffled heart sounds, and
jugular venous distention. Which complication should the nurse suspect?
A. Simple anxiety
B. Cardiac tamponade
C. Stable angina
D. Hypertensive urgency
Correct Answer: B
Rationale: Beck’s triad of hypotension, muffled heart sounds, and elevated jugular venous pressure is
classic for cardiac tamponade and requires immediate intervention.
Question 4. Which medication is commonly used to reduce preload and relieve ischemic
chest pain in acute coronary syndrome?
A. Nitroglycerin
B. High-dose beta blocker only
C. Calcium channel blocker exclusively
D. Digoxin
Correct Answer: A
HESI Medical-Surgical Nursing Comprehensive Examination 2026/2027 | Verified Questions
HESI Medical-Surgical Nursing
Comprehensive Examination 2026/2027 |
Verified Questions
HESI / Elsevier | Medical-Surgical Nursing Comprehensive Examination | University-Level Nursing
Students
55 Verified Questions | 4 Core Domains | Academic Year 2026/2027
Prepared by
HESI / Elsevier | Medical-Surgical Nursing Comprehensive Examination
Comprehensive Proctored Examination Actual Exam | Academic Year 2026/2027
HESI Medical-Surgical Nursing Comprehensive Examination 2026/2027 | Verified Questions
, INTRODUCTION
This comprehensive examination contains 55 verified questions designed to reinforce the official HESI
Medical-Surgical Nursing Comprehensive Examination course objectives for the Comprehensive
Proctored Examination. The questions are organized across four core domains: Cardiovascular and
Respiratory Disorders; Gastrointestinal and Renal Disorders; Neurological and Musculoskeletal
Disorders; and Endocrine, Hematologic, and Oncologic Disorders. Content is original and aligned to the
2026/2027 academic year, emphasizing clinical reasoning and foundational medical-surgical nursing
knowledge required for actual exam readiness and clinical proficiency.
ACTUAL QUESTIONS
Domain 1: Cardiovascular and Respiratory Disorders
Question 1. A client with acute coronary syndrome reports crushing chest pain. Which
laboratory value is most specific for myocardial injury?
A. Elevated cardiac troponin
B. Elevated CK only
C. Elevated BNP exclusively
D. Elevated D-dimer
Correct Answer: A
Rationale: Cardiac troponin is the preferred biomarker for detecting myocardial injury because of its
high sensitivity and specificity for cardiac muscle damage.
Question 2. Which ECG finding is most consistent with an acute ST-elevation myocardial
infarction?
A. Prolonged PR interval
B. Isolated U waves
C. ST-segment elevation in contiguous leads
D. Narrow QRS complexes only
Correct Answer: C
Rationale: ST-segment elevation in two or more contiguous leads indicates acute myocardial injury and
guides decisions about emergent reperfusion therapy.
Question 3. A client post-PCI develops sudden hypotension, muffled heart sounds, and
jugular venous distention. Which complication should the nurse suspect?
A. Simple anxiety
B. Cardiac tamponade
C. Stable angina
D. Hypertensive urgency
Correct Answer: B
Rationale: Beck’s triad of hypotension, muffled heart sounds, and elevated jugular venous pressure is
classic for cardiac tamponade and requires immediate intervention.
Question 4. Which medication is commonly used to reduce preload and relieve ischemic
chest pain in acute coronary syndrome?
A. Nitroglycerin
B. High-dose beta blocker only
C. Calcium channel blocker exclusively
D. Digoxin
Correct Answer: A
HESI Medical-Surgical Nursing Comprehensive Examination 2026/2027 | Verified Questions
