Pharmacology
for Nursing Infection and Antimicrobial Therapy
Comprehensive Study Guide
UPDATE
Actual Questions & Verified Answers
with Detailed Clinical Rationales
Practice Questions with Rationales
Nursing Program
Pharmacology
✓ 100% Verified Answers
✓ Complete Rationales Included
Exam (elaborations)
Instant PDF Download • Ready for Study
,Pharmacology for Nursing: Infection and Antimicrobial Therapy 2026/2027 UPDATE
1. A patient with a history of a severe anaphylactic reaction to Penicillin G is prescribed
Cefazolin for surgical prophylaxis. Which action by the nurse is most appropriate?
A. Hold the medication and notify the healthcare provider of the potential cross-sensitivity.
B. Administer the medication but keep an intubation kit at the bedside.
C. Administer the Cefazolin as ordered since it is a different class.
D. Pre-medicate the patient with diphenhydramine before administration.
Answer: A
Rationale: There is a 5% to 10% cross-sensitivity between penicillins and cephalosporins.
In cases of documented anaphylaxis to penicillin, cephalosporins should be avoided unless
absolutely necessary and managed under strict supervision.
2. Which laboratory value is the most critical for the nurse to monitor in a patient receiving
Gentamicin intravenously?
A. Serum Potassium
B. Serum Creatinine
C. Prothrombin Time (PT)
D. White Blood Cell Count
, Answer: B
Rationale: Gentamicin is an aminoglycoside known for significant nephrotoxicity.
Monitoring serum creatinine and BUN is essential to detect early signs of renal impairment.
3. A patient receiving Vancomycin infusion suddenly develops intense flushing, tachycardia,
and hypotension. What is the nurse’s priority action?
A. Immediately stop the infusion.
B. Administer a bolus of Normal Saline.
C. Administer epinephrine subcutaneously.
D. Slow the infusion rate and notify the provider.
Answer: D
Rationale: These are symptoms of Red Man Syndrome, a rate-related infusion reaction.
The priority is to slow the infusion rather than stop it entirely, as it is not a true allergic
IgE-mediated reaction.
4. What instruction is most important for a patient prescribed Tetracycline for the treatment
of acne?
A. Avoid sun exposure and use high-SPF sunscreen.
B. Take the medication with a full glass of milk.
C. Expect your urine to turn a bright orange color.
D. Stop the medication as soon as skin lesions clear.
for Nursing Infection and Antimicrobial Therapy
Comprehensive Study Guide
UPDATE
Actual Questions & Verified Answers
with Detailed Clinical Rationales
Practice Questions with Rationales
Nursing Program
Pharmacology
✓ 100% Verified Answers
✓ Complete Rationales Included
Exam (elaborations)
Instant PDF Download • Ready for Study
,Pharmacology for Nursing: Infection and Antimicrobial Therapy 2026/2027 UPDATE
1. A patient with a history of a severe anaphylactic reaction to Penicillin G is prescribed
Cefazolin for surgical prophylaxis. Which action by the nurse is most appropriate?
A. Hold the medication and notify the healthcare provider of the potential cross-sensitivity.
B. Administer the medication but keep an intubation kit at the bedside.
C. Administer the Cefazolin as ordered since it is a different class.
D. Pre-medicate the patient with diphenhydramine before administration.
Answer: A
Rationale: There is a 5% to 10% cross-sensitivity between penicillins and cephalosporins.
In cases of documented anaphylaxis to penicillin, cephalosporins should be avoided unless
absolutely necessary and managed under strict supervision.
2. Which laboratory value is the most critical for the nurse to monitor in a patient receiving
Gentamicin intravenously?
A. Serum Potassium
B. Serum Creatinine
C. Prothrombin Time (PT)
D. White Blood Cell Count
, Answer: B
Rationale: Gentamicin is an aminoglycoside known for significant nephrotoxicity.
Monitoring serum creatinine and BUN is essential to detect early signs of renal impairment.
3. A patient receiving Vancomycin infusion suddenly develops intense flushing, tachycardia,
and hypotension. What is the nurse’s priority action?
A. Immediately stop the infusion.
B. Administer a bolus of Normal Saline.
C. Administer epinephrine subcutaneously.
D. Slow the infusion rate and notify the provider.
Answer: D
Rationale: These are symptoms of Red Man Syndrome, a rate-related infusion reaction.
The priority is to slow the infusion rather than stop it entirely, as it is not a true allergic
IgE-mediated reaction.
4. What instruction is most important for a patient prescribed Tetracycline for the treatment
of acne?
A. Avoid sun exposure and use high-SPF sunscreen.
B. Take the medication with a full glass of milk.
C. Expect your urine to turn a bright orange color.
D. Stop the medication as soon as skin lesions clear.
