Name the locations of active marrow in adults: ~CORRECT
ANSWER~✓✓sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation?
~CORRECT ANSWER~✓✓yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th
month of gestation? ~CORRECT ANSWER~✓✓spleen
When does the bone marrow take over hematopoiesis? ~CORRECT
ANSWER~✓✓after birth
What are the stages in order of the erythrocyte lineage? ~CORRECT
ANSWER~✓✓(1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte,
(5)reticulocyte, (6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil)
lineage? ~CORRECT ANSWER~✓✓(1)myeloblast, (2)promyelocyte,
(3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
What are the stages in order of the macrophage lineage? ~CORRECT
ANSWER~✓✓(1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
,What are the stages in order of the platelet lineage? ~CORRECT
ANSWER~✓✓(1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte,
(4)platelet
What are the stages in order of the lymphocyte lineage? ~CORRECT
ANSWER~✓✓(1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
Which growth factors stimulate the erythrocyte lineage? ~CORRECT
ANSWER~✓✓GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages? ~CORRECT
ANSWER~✓✓GM-CSF, IL-3
Which growth factors stimulate the platelet lineage? ~CORRECT
ANSWER~✓✓GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage? ~CORRECT
ANSWER~✓✓IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe? ~CORRECT
ANSWER~✓✓transferrin
What is the major storage form of Fe? ~CORRECT ANSWER~✓✓ferritin What is
the long-term (H20) insoluble Fe storage form called? ~CORRECT
ANSWER~✓✓hemosiderin
, Excess Iron is stored where? What does this cause? ~CORRECT
ANSWER~✓✓tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to? ~CORRECT ANSWER~✓✓excessive formation of
porphrins due to blockages in any enzymatic step in the heme synthesis
pathway.
Red or port wine colored urine can be seen in which condition related to the
build up of heme precursors? ~CORRECT ANSWER~✓✓porphyria
Neuropsychiatirc symptoms are seen when a build up of which precursors
occurs? ~CORRECT ANSWER~✓✓early precursors (Delta-aminolevulinic
acid/Porphobilinogen)
Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a
build up of which precursors occurs? ~CORRECT ANSWER~✓✓later precursors
(uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)
Synthesis of heme requires what two components? ~CORRECT
ANSWER~✓✓iron, protoporphyrin
What are the heme precursors in order of synthesis? ~CORRECT
ANSWER~✓✓(1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin, (6)heme
ANSWER~✓✓sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation?
~CORRECT ANSWER~✓✓yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th
month of gestation? ~CORRECT ANSWER~✓✓spleen
When does the bone marrow take over hematopoiesis? ~CORRECT
ANSWER~✓✓after birth
What are the stages in order of the erythrocyte lineage? ~CORRECT
ANSWER~✓✓(1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte,
(5)reticulocyte, (6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil)
lineage? ~CORRECT ANSWER~✓✓(1)myeloblast, (2)promyelocyte,
(3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
What are the stages in order of the macrophage lineage? ~CORRECT
ANSWER~✓✓(1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
,What are the stages in order of the platelet lineage? ~CORRECT
ANSWER~✓✓(1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte,
(4)platelet
What are the stages in order of the lymphocyte lineage? ~CORRECT
ANSWER~✓✓(1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
Which growth factors stimulate the erythrocyte lineage? ~CORRECT
ANSWER~✓✓GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages? ~CORRECT
ANSWER~✓✓GM-CSF, IL-3
Which growth factors stimulate the platelet lineage? ~CORRECT
ANSWER~✓✓GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage? ~CORRECT
ANSWER~✓✓IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe? ~CORRECT
ANSWER~✓✓transferrin
What is the major storage form of Fe? ~CORRECT ANSWER~✓✓ferritin What is
the long-term (H20) insoluble Fe storage form called? ~CORRECT
ANSWER~✓✓hemosiderin
, Excess Iron is stored where? What does this cause? ~CORRECT
ANSWER~✓✓tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to? ~CORRECT ANSWER~✓✓excessive formation of
porphrins due to blockages in any enzymatic step in the heme synthesis
pathway.
Red or port wine colored urine can be seen in which condition related to the
build up of heme precursors? ~CORRECT ANSWER~✓✓porphyria
Neuropsychiatirc symptoms are seen when a build up of which precursors
occurs? ~CORRECT ANSWER~✓✓early precursors (Delta-aminolevulinic
acid/Porphobilinogen)
Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a
build up of which precursors occurs? ~CORRECT ANSWER~✓✓later precursors
(uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)
Synthesis of heme requires what two components? ~CORRECT
ANSWER~✓✓iron, protoporphyrin
What are the heme precursors in order of synthesis? ~CORRECT
ANSWER~✓✓(1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin, (6)heme
