This NS 1400 In-Class Test #3 2026/2027 study document provides a comprehensive 19-page question-and-answer review centered on cancer biology, lung cancer, epidemiological research, cancer health disparities, social determinants of health, and tobacco-related public health policy. The material begins with foundational cancer concepts, including uncontrolled cellular growth, apoptosis, differences between normal and cancer cells, environmental, behavioral and genetic cancer risk factors, age-related cancer risk, and disparities in cancer incidence.
A major section examines epidemiology and cancer research methods through the relationship between smoking and lung cancer. The document reviews the Doll-Hill study and prospective cohort methodology while distinguishing cross-sectional, cohort, case-control, ecological, observational, experimental, randomized, double-blind, placebo-controlled, and community trials. It also explains exposure as an independent variable and outcome as a dependent variable, providing students with terminology needed to interpret epidemiological evidence and study designs.
The cancer-biology material explores the cell cycle, oncogenes, tumor suppressor genes, genetic mutations, cancer development, angiogenesis, apoptosis resistance, cellular immortalization, invasion and metastasis, epithelial-mesenchymal transition, immune evasion, tumor-promoting inflammation, genome instability, and altered energy metabolism associated with the Warburg effect. The document reviews the major hallmarks of cancer and explains mechanisms cancer cells use to achieve growth-factor independence, suppress anti-growth signaling, induce angiogenesis, evade immune destruction, and maintain replicative potential.
There is particularly detailed coverage of lung cancer and small-cell lung cancer (SCLC). Topics include lung anatomy, respiratory and conducting zones, SCLC and non-small-cell lung cancer, smoking as a risk factor, prognosis, common symptoms such as cough, dyspnea and hemoptysis, TP53 and RB1 tumor-suppressor genes, tumor biopsy, TNM classification, lung cancer stages 1–4, metastasis, and treatment approaches involving surgery, radiotherapy, chemotherapy, chemoradiotherapy and immunotherapy.
The final sections connect cancer with population health and health equity. They address equality versus equity, justice, the five social determinants of health, socioeconomic and environmental influences on health, healthcare access, education, neighborhood conditions, the equity ecosystem, the Theory of Change model, racial disparities in lung cancer, insurance status, occupational exposure, intersectionality, smoking patterns by education and income, and the economic externalities of tobacco use. The material concludes with public-health approaches to smoking, including information campaigns, tobacco taxation, and place-based smoking restrictions.
Relevant Students: NS 1400 students, undergraduate health science students, nursing students, public health students, epidemiology students, pre-nursing students, pre-medical students, cancer biology students, population health students, students studying social determinants of health, and students preparing for examinations covering cancer, lung cancer, epidemiological research methods, health disparities, tobacco use, and health policy.
Keywords: NS 1400 In Class Test 3, NS 1400 exam questions, NS 1400 questions and answers, NS 1400 Test 3 2026, NS 1400 Test 3 2027, cancer biology exam questions, cancer questions and answers, lung cancer study guide, lung cancer exam questions, small cell lung cancer, SCLC questions, NSCLC questions, hallmarks of cancer, oncogenes and tumor suppressor genes, TP53 and RB1, cancer cell cycle, apoptosis cancer, angiogenesis cancer, cancer invasion and metastasis, Warburg effect, epidemiology exam questions, epidemiological study designs, cohort study, case control study, cross sectional study, ecological study, Doll Hill study, smoking and lung cancer, cancer health disparities, social determinants of health, health equity, racial disparities in cancer, tobacco public health policy, lung cancer staging, TNM classification, cancer treatment, public health exam prep
Content preview
NS 1400 In-class Test #3
2026/2027 Exam All Answers
and Illustrations Given
cancer - ANSWER ✔✔A large group of diseases that start in almost
any organ or tissue of the body when abnormal cells grow uncontrollably,
go beyond their usual boundaries to invade adjoining parts of the body,
and/or spread to other organs.
Apoptosis - ANSWER ✔✔programmed cell death
4 ways cancer cells are different from normal cells - ANSWER ✔✔1.
grow in the absence of signals
2. ignore signals to die or stop dividing
3. invade into nearby areas
,4. tell blood vessels to grow toward tumors
cancer death in the US - ANSWER ✔✔1. second leading cause,
exceeded by heart disease
2. one in every four deaths
the geography of cancer - ANSWER ✔✔1. deep south: poor
2. new england: old
three broad sets of factors that causes cancer - ANSWER ✔✔1.
environmental
2. behavior
3. genetic
relationship between higher age and cancer - ANSWER ✔✔1. more
time for damage in cells to build up
2. more exposure to environmental and behavioral factors
racial disparity of cancer - ANSWER ✔✔Highest: African American
men
Lowest: Asian/Pacific Islander women
colorectal cancer - ANSWER ✔✔cancer of the colon and rectum
, Trend of lung cancer over the past two decades - ANSWER ✔✔both
rates of new cancers and mortality decreased
The Doll-Hill Study: Research Problems and implications - ANSWER
✔✔1. Lung cancer might be caused by all sorts of things.
--> cross-sectional study won't work
2. The relationship between smoking (or indeed any environmental
factor) and lung cancer is not instantaneous
--> need to follow people
The Doll-Hill Study: solution - ANSWER ✔✔prospective cohort study
design using British doctors
prospective cohort study design - ANSWER ✔✔follows, over time,
groups of individuals who are alike in
many ways but differ by a certain characteristic. We then see if there is a
relationship
between that certain characteristic and our outcome(s) of interest
Why choosing British doctors for the Doll-Hill study is a good idea (3) -
ANSWER ✔✔1. same occupation, education, income, background
3
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