• PN HESI
Pharmacology 09/11/2026
Exam
2026 PN HESI Pharmacology 2 Proctored Exam
Review | Comprehensive Practice Question Bank
& Verified Answers (Next Gen NCLEX Update)
A client is being treated for osteoporosis with alendronate (Fosamax), and the nurse has completed discharge
teaching regarding medication administration. Which morning schedule would indicate to the nurse that the
client teaching has been effective?
A) Take medication, go for a 30 minute morning walk, then eat breakfast.
B) Take medication, rest in bed for 30 minutes, eat breakfast, go for morning walk.
C) Take medication with breakfast, then take a 30 minute morning walk.
D) Go for a 30 minute morning walk, eat breakfast, then take medication. –
Correct Answer :A) Take medication, go for a 30 minute morning walk, then eat breakfast.
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Alendronate (Fosamax) is best absorbed when taken thirty minutes before eating in the morning. The client
should also be advised to remain in an upright position for at least thirty minutes after taking the medication to
reduce the risk of esophageal reflux and irritation. (A) is the best schedule to meet these needs. (B, C, and D) do
not meet these criteria.
A healthcare provider prescribes cephalexin monohydrate (Keflex) for a client with a postoperative infection. It
is most important for the nurse to assess for what additional drug allergy before administering this prescription?
A) Penicillins.
B) Aminoglycosides.
C) Erythromycins.
D) Sulfonamides. –
Correct Answer :A) Penicillins.
Cross-allergies exist between penicillins (A) and cephalosporins, such as cephalexin monohydrate (Keflex), so
checking for penicillin allergy is a wise precaution before administering this drug.
Which nursing intervention is most important when caring for a client receiving the antimetabolite cytosine
arabinoside (Arc-C) for chemotherapy?
A) Hydrate the client with IV fluids before and after infusion.
B) Assess the client for numbness and tingling of extremities.
C) Inspect the client's oral mucosa for ulcerations.
D) Monitor the client's urine pH for increased acidity. - Correct Answer :C) Inspect the client's oral mucosa for
ulcerations.
Cytosine arabinoside (Arc-C) affects the rapidly growing cells of the body, therefore stomatitis and mucosal
ulcerations are key signs of antimetabolite toxicity (C). (A, B, and D) are not typical interventions associated with
the administration of antimetabolites.
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
When assessing an adolescent who recently overdosed on acetaminophen (Tylenol), it is most important for the
nurse to assess for pain in which area of the body?
A) Flank.
B) Abdomen.
C) Chest.
D) Head. - Correct Answer :B) Abdomen.
Acetaminophen toxicity can result in liver damage; therefore, it is especially important for the nurse to assess for
pain in the right upper quadrant of the abdomen (B), which might indicate liver damage. (A, C, and D) are not
areas where pain would be anticipated.
An adult client is given a prescription for a scopolamine patch (Transderm Scop) to prevent motion sickness
while on a cruise. Which information should the nurse provide to the client?
A) Apply the patch at least 4 hours prior to departure.
B) Change the patch every other day while on the cruise.
C) Place the patch on a hairless area at the base of the skull.
D) Drink no more than 2 alcoholic drinks during the cruise. - Correct Answer :A) Apply the patch at least 4 hours
prior to departure.
Scopolamine, an anticholinergic agent, is used to prevent motion sickness and has a peak onset in 6 hours, so
the client should be instructed to apply the patch at least 4 hours before departure (A) on the cruise ship. The
duration of the transdermal patch is 72 hours, so (B) is not needed. Scolopamine blocks muscarinic receptors in
the inner ear and to the vomiting center, so the best application site of the patch is behind the ear, not at the
base of the skull (C). Anticholinergic medications are CNS depressants, so the client should be instructed to
avoid alcohol (D) while using the patch.
The nurse is reviewing the use of the patient-controlled analgesia (PCA) pump with a client in the immediate
postoperative period. The client will receive morphine 1 mg IV per hour basal rate with 1 mg IV every 15 minutes
per PCA to total 5 mg IV maximally per hour. What assessment has the highest priority before initiating the PCA
pump?
A) The expiration date on the morphine syringe in the pump.
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
B) The rate and depth of the client's respirations.
C) The type of anesthesia used during the surgical procedure.
D) The client's subjective and objective signs of pain. - Correct Answer :B) The rate and depth of the client's
respirations.
A life-threatening side effect of intravenous administration of morphine sulfate, an opiate narcotic, is respiratory
depression (B). The PCA pump should be stopped and the healthcare provider notified if the client's respiratory
rate falls below 12 breaths per minute, and the nurse should anticipate adjustments in the client's dosage before
the PCA pump is restarted. (A, C, and D) provide helpful information, but are not as high a priority as the
assessment described in (B).
A medication that is classified as a beta-1 agonist is most commonly prescribed for a client with which condition?
A) Glaucoma.
B) Hypertension.
C) Heart failure.
D) Asthma. - Correct Answer :C) Heart failure.
Beta-1 agonists improve cardiac output by increasing the heart rate and blood pressure and are indicated in heart
failure (C), shock, atrioventricular block dysrhythmias, and cardiac arrest. Glaucoma (A) is managed using
adrenergic agents and beta-adrenergic blocking agents. Beta-1 blocking agents are used in the management of
hypertension (B). Medications that stimulate beta-2 receptors in the bronchi are effective for
bronchoconstriction in respiratory disorders, such as asthma (D).
A female client with rheumatoid arthritis take ibuprofen (Motrin) 600 mg PO 4 times a day. To prevent
gastrointestinal bleeding, misoprostol (Cytotec) 100 mcg PO is prescribed. Which information is most important
for the nurse to include in client teaching?
A) Use contraception during intercourse.
B) Ensure the Cytotec is taken on an empty stomach.
C) Encourage oral fluid intake to prevent constipation.
D) Take Cytotec 30 minutes prior to Motrin. - Correct Answer :A) Use contraception during intercourse.
P 4
Pharmacology 09/11/2026
Exam
2026 PN HESI Pharmacology 2 Proctored Exam
Review | Comprehensive Practice Question Bank
& Verified Answers (Next Gen NCLEX Update)
A client is being treated for osteoporosis with alendronate (Fosamax), and the nurse has completed discharge
teaching regarding medication administration. Which morning schedule would indicate to the nurse that the
client teaching has been effective?
A) Take medication, go for a 30 minute morning walk, then eat breakfast.
B) Take medication, rest in bed for 30 minutes, eat breakfast, go for morning walk.
C) Take medication with breakfast, then take a 30 minute morning walk.
D) Go for a 30 minute morning walk, eat breakfast, then take medication. –
Correct Answer :A) Take medication, go for a 30 minute morning walk, then eat breakfast.
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Alendronate (Fosamax) is best absorbed when taken thirty minutes before eating in the morning. The client
should also be advised to remain in an upright position for at least thirty minutes after taking the medication to
reduce the risk of esophageal reflux and irritation. (A) is the best schedule to meet these needs. (B, C, and D) do
not meet these criteria.
A healthcare provider prescribes cephalexin monohydrate (Keflex) for a client with a postoperative infection. It
is most important for the nurse to assess for what additional drug allergy before administering this prescription?
A) Penicillins.
B) Aminoglycosides.
C) Erythromycins.
D) Sulfonamides. –
Correct Answer :A) Penicillins.
Cross-allergies exist between penicillins (A) and cephalosporins, such as cephalexin monohydrate (Keflex), so
checking for penicillin allergy is a wise precaution before administering this drug.
Which nursing intervention is most important when caring for a client receiving the antimetabolite cytosine
arabinoside (Arc-C) for chemotherapy?
A) Hydrate the client with IV fluids before and after infusion.
B) Assess the client for numbness and tingling of extremities.
C) Inspect the client's oral mucosa for ulcerations.
D) Monitor the client's urine pH for increased acidity. - Correct Answer :C) Inspect the client's oral mucosa for
ulcerations.
Cytosine arabinoside (Arc-C) affects the rapidly growing cells of the body, therefore stomatitis and mucosal
ulcerations are key signs of antimetabolite toxicity (C). (A, B, and D) are not typical interventions associated with
the administration of antimetabolites.
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
When assessing an adolescent who recently overdosed on acetaminophen (Tylenol), it is most important for the
nurse to assess for pain in which area of the body?
A) Flank.
B) Abdomen.
C) Chest.
D) Head. - Correct Answer :B) Abdomen.
Acetaminophen toxicity can result in liver damage; therefore, it is especially important for the nurse to assess for
pain in the right upper quadrant of the abdomen (B), which might indicate liver damage. (A, C, and D) are not
areas where pain would be anticipated.
An adult client is given a prescription for a scopolamine patch (Transderm Scop) to prevent motion sickness
while on a cruise. Which information should the nurse provide to the client?
A) Apply the patch at least 4 hours prior to departure.
B) Change the patch every other day while on the cruise.
C) Place the patch on a hairless area at the base of the skull.
D) Drink no more than 2 alcoholic drinks during the cruise. - Correct Answer :A) Apply the patch at least 4 hours
prior to departure.
Scopolamine, an anticholinergic agent, is used to prevent motion sickness and has a peak onset in 6 hours, so
the client should be instructed to apply the patch at least 4 hours before departure (A) on the cruise ship. The
duration of the transdermal patch is 72 hours, so (B) is not needed. Scolopamine blocks muscarinic receptors in
the inner ear and to the vomiting center, so the best application site of the patch is behind the ear, not at the
base of the skull (C). Anticholinergic medications are CNS depressants, so the client should be instructed to
avoid alcohol (D) while using the patch.
The nurse is reviewing the use of the patient-controlled analgesia (PCA) pump with a client in the immediate
postoperative period. The client will receive morphine 1 mg IV per hour basal rate with 1 mg IV every 15 minutes
per PCA to total 5 mg IV maximally per hour. What assessment has the highest priority before initiating the PCA
pump?
A) The expiration date on the morphine syringe in the pump.
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
B) The rate and depth of the client's respirations.
C) The type of anesthesia used during the surgical procedure.
D) The client's subjective and objective signs of pain. - Correct Answer :B) The rate and depth of the client's
respirations.
A life-threatening side effect of intravenous administration of morphine sulfate, an opiate narcotic, is respiratory
depression (B). The PCA pump should be stopped and the healthcare provider notified if the client's respiratory
rate falls below 12 breaths per minute, and the nurse should anticipate adjustments in the client's dosage before
the PCA pump is restarted. (A, C, and D) provide helpful information, but are not as high a priority as the
assessment described in (B).
A medication that is classified as a beta-1 agonist is most commonly prescribed for a client with which condition?
A) Glaucoma.
B) Hypertension.
C) Heart failure.
D) Asthma. - Correct Answer :C) Heart failure.
Beta-1 agonists improve cardiac output by increasing the heart rate and blood pressure and are indicated in heart
failure (C), shock, atrioventricular block dysrhythmias, and cardiac arrest. Glaucoma (A) is managed using
adrenergic agents and beta-adrenergic blocking agents. Beta-1 blocking agents are used in the management of
hypertension (B). Medications that stimulate beta-2 receptors in the bronchi are effective for
bronchoconstriction in respiratory disorders, such as asthma (D).
A female client with rheumatoid arthritis take ibuprofen (Motrin) 600 mg PO 4 times a day. To prevent
gastrointestinal bleeding, misoprostol (Cytotec) 100 mcg PO is prescribed. Which information is most important
for the nurse to include in client teaching?
A) Use contraception during intercourse.
B) Ensure the Cytotec is taken on an empty stomach.
C) Encourage oral fluid intake to prevent constipation.
D) Take Cytotec 30 minutes prior to Motrin. - Correct Answer :A) Use contraception during intercourse.
P 4
