• PN HESI
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 3 2026 Review Test
Bank | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
Which factor is most important to ensure compliance when planning to teach a client about a drug regimen?
A. Genetics
B. Client age
C. Client education
D. Absorption rate –
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Correct Answer :C. Client education
The client's educational level is the most important factor when planning teaching to ensure a client's
compliance with taking a prescribed drug. Options A and D are physiologic responses that do not relate to a
client's compliance. Although maturity level and age contribute to compliance, the client's basic understanding
of instructions, which is best indicated by educational level, is more significant.
A client is receiving acyclovir sodium IV for a severe herpes simplex infection. Which intervention should the
nurse implement during this drug therapy?
A. Maintain respiratory isolation precautions.
B. Increase daily fluids to 2000 to 4000 mL/day.
C. Administer with meals to decrease gastric irritation.
D. Assess for signs of severe liver dysfunction. –
Correct Answer :B. Increase daily fluids to 2000 to 4000 mL/day.
Increasing fluid intake during treatment prevents precipitation of the drug in the renal tubules, which could lead
to obstructive problems that impair kidney function. Acute glomerulonephritis is a possible complication of
acyclovir sodium therapy. Options A, C, and D are unrelated interventions for treatment with acyclovir sodium.
Which physiologic mechanism explains a drug's increased metabolism that is triggered by a disease process?
A. Selectivity response
B. Pharmacokinetics
C. Pharmacodynamics
D. Pharmacotherapeutics - Correct Answer :B. Pharmacokinetics
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
Pharmacokinetics describes the physiologic process of a drug's movement throughout the body and how the
drug's interaction is affected by an underlying disease. Selectivity, or a selective drug, is defined as a drug that
elicits only the response for which it is given. Pharmacodynamics is the impact of drugs on the body.
Pharmacotherapeutics is defined as the use of drugs to diagnose, prevent, or treat disease or prevent
pregnancy.
An older client is receiving a water-soluble drug that is more than the average dose for a young adult. Which
action should the nurse implement first?
A. Obtain a prescription for lower medication dosages.
B. Determine the drug's serum levels for toxicity.
C. Start IV fluids to decrease the serum drug levels.
D. Hold the next dosage and notify the health care provider.
- Correct Answer :B. Determine the drug's serum levels for toxicity.
Older clients usually have a decline in lean body mass and total body water that causes water-soluble drugs to
become distributed in fluid compartments, resulting in an increased concentration, so determining the drug's
serum level for toxicity should be implemented first. Although options A, C, and D may be indicated, an increased
plasma drug level should be the determining factor to consider when water-soluble drugs warrant a reduced
dosage in the older client.
The health care provider prescribes cisplatin to be administered in 5% dextrose and 0.45% normal saline with
mannitol added. Which assessment parameters would be most helpful to the nurse in evaluating the
effectiveness of the therapy?
A. Oral temperature
B. Blood cultures
C. Urine output
D. Liver enzyme levels
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
- Correct Answer :C. Urine output
The effectiveness of the diuresis is best measured by urine output. Mannitol, an osmotic diuretic, is given during
cisplatin therapy to promote diuresis and reduce the risk of nephrotoxicity and ototoxicity associated with this
chemotherapeutic agent. Options A, B, and D do not provide information about the risk for nephrotoxicity and
ototoxicity related to cisplatin administration.
A 4-year-old child is receiving chemotherapy for acute lymphocytic leukemia. Which laboratory result should the
nurse examine to assess the child's risk for infection?
A. Neutrophil count
B. Platelet count
C. Reticulocyte count
D. Lymphocyte count –
Correct Answer :A. Neutrophil
During chemotherapy, granulocytes are significantly suppressed. Because neutrophils comprise 60% to 70% of
the granulocyte count, these levels are the most useful laboratory results of the options presented to determine
the child's risk for infection. Options B, C, and D are not as useful as option A in determining risk of infection.
A pediatric client is discharged home with multiple prescriptions for medications. Which information should the
nurse provide that is most helpful to the parents when managing the medication regimens?
A. Maintain a drug administration record.
B. Fill all prescriptions at one pharmacy.
C. Allow one person to give the medications.
D. Give all medications in small volumes. - Correct Answer :A. Maintain a drug administration record.
P 4
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 3 2026 Review Test
Bank | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
Which factor is most important to ensure compliance when planning to teach a client about a drug regimen?
A. Genetics
B. Client age
C. Client education
D. Absorption rate –
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Correct Answer :C. Client education
The client's educational level is the most important factor when planning teaching to ensure a client's
compliance with taking a prescribed drug. Options A and D are physiologic responses that do not relate to a
client's compliance. Although maturity level and age contribute to compliance, the client's basic understanding
of instructions, which is best indicated by educational level, is more significant.
A client is receiving acyclovir sodium IV for a severe herpes simplex infection. Which intervention should the
nurse implement during this drug therapy?
A. Maintain respiratory isolation precautions.
B. Increase daily fluids to 2000 to 4000 mL/day.
C. Administer with meals to decrease gastric irritation.
D. Assess for signs of severe liver dysfunction. –
Correct Answer :B. Increase daily fluids to 2000 to 4000 mL/day.
Increasing fluid intake during treatment prevents precipitation of the drug in the renal tubules, which could lead
to obstructive problems that impair kidney function. Acute glomerulonephritis is a possible complication of
acyclovir sodium therapy. Options A, C, and D are unrelated interventions for treatment with acyclovir sodium.
Which physiologic mechanism explains a drug's increased metabolism that is triggered by a disease process?
A. Selectivity response
B. Pharmacokinetics
C. Pharmacodynamics
D. Pharmacotherapeutics - Correct Answer :B. Pharmacokinetics
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
Pharmacokinetics describes the physiologic process of a drug's movement throughout the body and how the
drug's interaction is affected by an underlying disease. Selectivity, or a selective drug, is defined as a drug that
elicits only the response for which it is given. Pharmacodynamics is the impact of drugs on the body.
Pharmacotherapeutics is defined as the use of drugs to diagnose, prevent, or treat disease or prevent
pregnancy.
An older client is receiving a water-soluble drug that is more than the average dose for a young adult. Which
action should the nurse implement first?
A. Obtain a prescription for lower medication dosages.
B. Determine the drug's serum levels for toxicity.
C. Start IV fluids to decrease the serum drug levels.
D. Hold the next dosage and notify the health care provider.
- Correct Answer :B. Determine the drug's serum levels for toxicity.
Older clients usually have a decline in lean body mass and total body water that causes water-soluble drugs to
become distributed in fluid compartments, resulting in an increased concentration, so determining the drug's
serum level for toxicity should be implemented first. Although options A, C, and D may be indicated, an increased
plasma drug level should be the determining factor to consider when water-soluble drugs warrant a reduced
dosage in the older client.
The health care provider prescribes cisplatin to be administered in 5% dextrose and 0.45% normal saline with
mannitol added. Which assessment parameters would be most helpful to the nurse in evaluating the
effectiveness of the therapy?
A. Oral temperature
B. Blood cultures
C. Urine output
D. Liver enzyme levels
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
- Correct Answer :C. Urine output
The effectiveness of the diuresis is best measured by urine output. Mannitol, an osmotic diuretic, is given during
cisplatin therapy to promote diuresis and reduce the risk of nephrotoxicity and ototoxicity associated with this
chemotherapeutic agent. Options A, B, and D do not provide information about the risk for nephrotoxicity and
ototoxicity related to cisplatin administration.
A 4-year-old child is receiving chemotherapy for acute lymphocytic leukemia. Which laboratory result should the
nurse examine to assess the child's risk for infection?
A. Neutrophil count
B. Platelet count
C. Reticulocyte count
D. Lymphocyte count –
Correct Answer :A. Neutrophil
During chemotherapy, granulocytes are significantly suppressed. Because neutrophils comprise 60% to 70% of
the granulocyte count, these levels are the most useful laboratory results of the options presented to determine
the child's risk for infection. Options B, C, and D are not as useful as option A in determining risk of infection.
A pediatric client is discharged home with multiple prescriptions for medications. Which information should the
nurse provide that is most helpful to the parents when managing the medication regimens?
A. Maintain a drug administration record.
B. Fill all prescriptions at one pharmacy.
C. Allow one person to give the medications.
D. Give all medications in small volumes. - Correct Answer :A. Maintain a drug administration record.
P 4
