• PN HESI
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 2 2026 Review Test
Bank 1 | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
A client who received a prescription for cyclosporine ophthalmic emulsion for dry eyes asks the practical nurse
(PN) if it is safe to continue using artificial tears. What information should the PN provide?
a. Avoid the use of artificial tears because they decrease the efficacy of cyclosporine.
b. Discontinue the use of both products if transient blurring occurs after administration.
c. Allow a 15-minute interval between the administration of cyclosporine and artificial tears.
d. Discontinue the use of cyclosporine and artificial tears when tear production reaches a normal level.
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
- Correct Answer :c. Allow a 15-minute interval between the administration of cyclosporine and artificial tears.
Rationale:
Cyclosporine, an ophthalmic emulsion which increases tear production, may be used in conjunction with artificial
tears as long as the products are administered 15 minutes apart. Transient blurring after administration is a side
effect of cyclosporine and does not necessitate discontinuation of the medication. After tear production is
increased, artificial tears may be stopped, but discontinuing cyclosporine will result in a decrease in tear
production.
A first-day postoperative client vomits 30 minutes after receiving a dose of hydromorphone. What initial
intervention is best for the practical nurse (PN) to implement?
a. Obtain a prescription for nasogastric intubation.
b. Administer a prn dose of ondansetron.
c. Reduce the next scheduled dose of hydromorphone.
d. Assess the client's abdomen and bowel sounds
- Correct Answer :b. Administer a prn dose of ondansetron.
Rationale:
Because the emesis appears to be directly related to the administration of the opiate analgesic, the first action
should be to reduce the client's nausea with the administration of the ondansetron, which is an antiemetic.
A client has been prescribed losartan. Which change in data indicates to the practical nurse (PN) that the desired
effect of this medication has been achieved?
a. Dependent edema reduced from +3 to +1.
b. Serum HDL increased from 35 to 55 mg/dL.
c. Pulse rate reduced from 150 to 90 beats/min.
d. Blood pressure reduced from 160/90 to 130/80 mm Hg.
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
- Correct Answer :d. Blood pressure reduced from 160/90 to 130/80 mm Hg.
Rationale:
Losartan is prescribed for the treatment of hypertension. The desired effect is a decrease in blood pressure.
A child is admitted to the emergency department for accidental ingestion of a poison. The practical nurse (PN)
should know that inducing vomiting is recommended for which child?
a. An 8 month old who ate four to six ibuprofen tablets
b. A 3 year old who drank an unknown amount of charcoal lighter fluid
c. A 16 month old who drank 2 ounces of acetaminophen elixir
d. A 2 year old who ate a handful of automatic dishwasher detergent –
Correct Answer :c. A 16 month old who drank 2 ounces of acetaminophen elixir
Rationale:
Emesis should be induced for the child who drank the large dose of acetaminophen elixir because this
medication is hepatotoxic. Vomiting is contraindicated for children younger than 1 year of age. Inducing vomiting
of corrosives such as dishwasher detergents and lighter fluid is contraindicated.
A practical nurse (PN) is reviewing teaching with the client and/or significant others about the concurrent use of
benztropine and olanzapine to manage psychotic behavior. What information should the PN reinforce?
a. Benztropine will reduce the olanzapine's side effect of urinary retention.
b. Benztropine potentiates the effect of olanzapine.
c. The benztropine is used to control the side effects of olanzapine.
d. The combined effect of these drugs will modify psychotic behavior. - Correct Answer :c. The benztropine is
used to control the side effects of olanzapine.
Rationale:
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
Benztropine, an anticholinergic drug, is used to control extrapyramidal symptoms associated with olanzapine
use. Caution is required in the dosage of benztropine used in conjunction with olanzapine.
A client diagnosed with a herniated disc is prescribed hydrocodone/acetaminophen 10 mg/300 mg prn every 4 to
6 hours. As the practical nurse (PN) enters the client's room to administer their requested medication, the client
is seen talking and laughing with his visiting family. Which action should the PN implement?
a. Hold the pain medication until after the visitors leave.
b. Notify the health care provider of the client's drug-seeking behavior.
c. Administer analgesia as requested by the client.
d. Inform the client based on their display behavior, the medication is not needed. –
Correct Answer :c. Administer analgesia as requested by the client.
Rationale:
The medication should be administered as per client's request. The client's self-report of pain is the single most
reliable indication of the existence, character, and intensity of pain. Analgesics should be administered as soon
as pain occurs and before it increases in intensity. The PN should consult with the charge nurse after
administering the medication about the situation.
The nurse is assisting with evaluating the effectiveness of the drug amiodarone. Which client statement best
indicates the drug has been effective?
a. "I have not had as many spells of angina."
b. "I have not had as much swelling in my ankles lately."
c. "My doctor told me my cholesterol levels were getting better every visit."
d. "I do not notice as many irregular heartbeats as before I started taking this medication." - Correct Answer :d.
"I do not notice as many irregular heartbeats as before I started taking this medication."
Rationale:
Amiodarone is the first choice drugs to treat ventricular dysrhythmias. It will not reduce angina spells, reduce
ankle swelling, or improve cholesterol levels.
P 4
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 2 2026 Review Test
Bank 1 | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
A client who received a prescription for cyclosporine ophthalmic emulsion for dry eyes asks the practical nurse
(PN) if it is safe to continue using artificial tears. What information should the PN provide?
a. Avoid the use of artificial tears because they decrease the efficacy of cyclosporine.
b. Discontinue the use of both products if transient blurring occurs after administration.
c. Allow a 15-minute interval between the administration of cyclosporine and artificial tears.
d. Discontinue the use of cyclosporine and artificial tears when tear production reaches a normal level.
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
- Correct Answer :c. Allow a 15-minute interval between the administration of cyclosporine and artificial tears.
Rationale:
Cyclosporine, an ophthalmic emulsion which increases tear production, may be used in conjunction with artificial
tears as long as the products are administered 15 minutes apart. Transient blurring after administration is a side
effect of cyclosporine and does not necessitate discontinuation of the medication. After tear production is
increased, artificial tears may be stopped, but discontinuing cyclosporine will result in a decrease in tear
production.
A first-day postoperative client vomits 30 minutes after receiving a dose of hydromorphone. What initial
intervention is best for the practical nurse (PN) to implement?
a. Obtain a prescription for nasogastric intubation.
b. Administer a prn dose of ondansetron.
c. Reduce the next scheduled dose of hydromorphone.
d. Assess the client's abdomen and bowel sounds
- Correct Answer :b. Administer a prn dose of ondansetron.
Rationale:
Because the emesis appears to be directly related to the administration of the opiate analgesic, the first action
should be to reduce the client's nausea with the administration of the ondansetron, which is an antiemetic.
A client has been prescribed losartan. Which change in data indicates to the practical nurse (PN) that the desired
effect of this medication has been achieved?
a. Dependent edema reduced from +3 to +1.
b. Serum HDL increased from 35 to 55 mg/dL.
c. Pulse rate reduced from 150 to 90 beats/min.
d. Blood pressure reduced from 160/90 to 130/80 mm Hg.
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
- Correct Answer :d. Blood pressure reduced from 160/90 to 130/80 mm Hg.
Rationale:
Losartan is prescribed for the treatment of hypertension. The desired effect is a decrease in blood pressure.
A child is admitted to the emergency department for accidental ingestion of a poison. The practical nurse (PN)
should know that inducing vomiting is recommended for which child?
a. An 8 month old who ate four to six ibuprofen tablets
b. A 3 year old who drank an unknown amount of charcoal lighter fluid
c. A 16 month old who drank 2 ounces of acetaminophen elixir
d. A 2 year old who ate a handful of automatic dishwasher detergent –
Correct Answer :c. A 16 month old who drank 2 ounces of acetaminophen elixir
Rationale:
Emesis should be induced for the child who drank the large dose of acetaminophen elixir because this
medication is hepatotoxic. Vomiting is contraindicated for children younger than 1 year of age. Inducing vomiting
of corrosives such as dishwasher detergents and lighter fluid is contraindicated.
A practical nurse (PN) is reviewing teaching with the client and/or significant others about the concurrent use of
benztropine and olanzapine to manage psychotic behavior. What information should the PN reinforce?
a. Benztropine will reduce the olanzapine's side effect of urinary retention.
b. Benztropine potentiates the effect of olanzapine.
c. The benztropine is used to control the side effects of olanzapine.
d. The combined effect of these drugs will modify psychotic behavior. - Correct Answer :c. The benztropine is
used to control the side effects of olanzapine.
Rationale:
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
Benztropine, an anticholinergic drug, is used to control extrapyramidal symptoms associated with olanzapine
use. Caution is required in the dosage of benztropine used in conjunction with olanzapine.
A client diagnosed with a herniated disc is prescribed hydrocodone/acetaminophen 10 mg/300 mg prn every 4 to
6 hours. As the practical nurse (PN) enters the client's room to administer their requested medication, the client
is seen talking and laughing with his visiting family. Which action should the PN implement?
a. Hold the pain medication until after the visitors leave.
b. Notify the health care provider of the client's drug-seeking behavior.
c. Administer analgesia as requested by the client.
d. Inform the client based on their display behavior, the medication is not needed. –
Correct Answer :c. Administer analgesia as requested by the client.
Rationale:
The medication should be administered as per client's request. The client's self-report of pain is the single most
reliable indication of the existence, character, and intensity of pain. Analgesics should be administered as soon
as pain occurs and before it increases in intensity. The PN should consult with the charge nurse after
administering the medication about the situation.
The nurse is assisting with evaluating the effectiveness of the drug amiodarone. Which client statement best
indicates the drug has been effective?
a. "I have not had as many spells of angina."
b. "I have not had as much swelling in my ankles lately."
c. "My doctor told me my cholesterol levels were getting better every visit."
d. "I do not notice as many irregular heartbeats as before I started taking this medication." - Correct Answer :d.
"I do not notice as many irregular heartbeats as before I started taking this medication."
Rationale:
Amiodarone is the first choice drugs to treat ventricular dysrhythmias. It will not reduce angina spells, reduce
ankle swelling, or improve cholesterol levels.
P 4
