• PN HESI
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 1 2026 Review Test
Bank 1 | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
A client with tuberculosis (TB) asks the practical nurse (PN) the value of prescribed multidrug therapy. What
explanation should the PN provide?
A) Required to eradicate TB.
B) Enhances the effect of each drug.
C) Provides a faster effect than single drug therapy.
D) Reduces development of TB resistant drugs. –
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Correct Answer :D) Reduces development of TB resistant drugs.
Feedback:
The use of multiple medications reduces the possibility of the tubercle bacilli becoming drug resistant (D). (A, B,
and C) are incorrect.
The healthcare provider prescribes an antibiotic for a male adolescent with an upper respiratory tract infection
who asks the practical nurse (PN) how long the prescribed antibiotics should be taken. What information should
the PN provide?
A) Continue the medication until all of the prescription is taken.
B) Use the medication for 24 hours after the cough subsides.
C) Stop the medication when the temperature returns to normal.
D) Take any remaining capsules if the infection occurs again. –
Correct Answer :A) Continue the medication until all of the prescription is taken.
Feedback:
Although the client may feel better after 24 hours of antibiotics, the prescription (A) should be taken until all of it
is used. If the antibiotic is discontinued because symptoms have disappeared (B and C), pathogens have an
opportunity to increase in virulence or become resistant to the drug. Antibiotics should not be saved (D) for
other infections, but new symptoms should be evaluated by the healthcare provider.
A male client tells the practical nurse (PN) that he takes acetylsalicylic acid (aspirin) 325 mg daily. Which finding
should alert the PN that the client may be experiencing a side effect of salicylate therapy?
A) Skin tears.
B) Hypothermia.
C) Hepatotoxicity.
D) Gastrointestinal distress. - Correct Answer :D) Gastrointestinal distress.
Feedback:
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
Salicylates, such as aspirin, commonly irritate the gastric mucosa, causing gastrointestinal distress (D). (A, B, and
C) are inaccurate.
The healthcare provider prescribes celecoxib (Celebrex), a nonsteroidal antiinflammatory drug (NSAID), for a
client with osteoarthritis. Which finding in the client's history should the practical nurse (PN) report?
A) Gout.
B) Hypertension.
C) Diabetes mellitus.
D) Peptic-ulcer disease. –
Correct Answer :D) Peptic-ulcer disease.
Feedback:
Celecoxib (Celebrex), an NSAID, causes gastrointestinal irritation and bleeding. Peptic-ulcer disease is a
contraindication to therapy with NSAIDs (D). (A, B, and C) are inaccurate.
What laboratory results should the practical nurse monitor to evaluate the therapeutic effects of heparin?
A) Platelet count.
B) Hematocrit.
C) Prothrombin time (PT).
D) Activated partial thromboplastin time (APTT). –
Correct Answer :D) Activated partial thromboplastin time (APTT).
Feedback:
Ongoing APTT (D) values measure the prolongation times of thromboplastin in the clotting cascade, which is
monitored during heparin therapy. (A, B, and C) do not indicate the therapeutic action of heparin.
Which information should the practical nurse (PN) provide a client who receives a new prescription for a
benzodiazepine medication?
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
A) A list of foods to avoid while taking this prescription.
B) Symptoms that indicate increasing the dose of medication.
C) The interactions of alcohol consumption and CNS depressant drugs.
D) Explanations that support taking a work absence during drug therapy. –
Correct Answer :C) The interactions of alcohol consumption and CNS depressant drugs.
Feedback:
The concomitant use of alcohol and benzodiazepines (C), both CNS depressants, causes an increase in sedation,
which places the client at risk for injury and should be avoided. (A, B, and D) are not indicated.
Which information should the practical nurse (PN) reinforce with a client who is self-administering insulin
injections?
A) Shake the vial of insulin to mix the contents before administration.
B) Store opened vials of insulin in a refrigerator no more than 30 days.
C) Use a different syringe to prepare and inject each type of insulin.
D) Aspirate regular insulin in the syringe first when mixing insulins. -
Correct Answer :D) Aspirate regular insulin in the syringe first when mixing insulins.
Feedback:
When administering two types of insulin, the regular insulin should be prepared first (D) to prevent the
contamination of the regular insulin vial with long-acting insulins. Gently rolling the vial of insulin between the
palms of the hands is recommended, not (A). Opened vials of insulin can be stored at room temperature for 30
days after being opened, and refrigeration (B) is not necessary. Different syringes (C) are not needed when
administering two types of insulin.
What side effect should the practical nurse (PN) report to the healthcare provider for a client who is taking
prednisone (Deltasone)?
A) Dehydration.
B) Hypoglycemia.
P 4
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 1 2026 Review Test
Bank 1 | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
A client with tuberculosis (TB) asks the practical nurse (PN) the value of prescribed multidrug therapy. What
explanation should the PN provide?
A) Required to eradicate TB.
B) Enhances the effect of each drug.
C) Provides a faster effect than single drug therapy.
D) Reduces development of TB resistant drugs. –
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Correct Answer :D) Reduces development of TB resistant drugs.
Feedback:
The use of multiple medications reduces the possibility of the tubercle bacilli becoming drug resistant (D). (A, B,
and C) are incorrect.
The healthcare provider prescribes an antibiotic for a male adolescent with an upper respiratory tract infection
who asks the practical nurse (PN) how long the prescribed antibiotics should be taken. What information should
the PN provide?
A) Continue the medication until all of the prescription is taken.
B) Use the medication for 24 hours after the cough subsides.
C) Stop the medication when the temperature returns to normal.
D) Take any remaining capsules if the infection occurs again. –
Correct Answer :A) Continue the medication until all of the prescription is taken.
Feedback:
Although the client may feel better after 24 hours of antibiotics, the prescription (A) should be taken until all of it
is used. If the antibiotic is discontinued because symptoms have disappeared (B and C), pathogens have an
opportunity to increase in virulence or become resistant to the drug. Antibiotics should not be saved (D) for
other infections, but new symptoms should be evaluated by the healthcare provider.
A male client tells the practical nurse (PN) that he takes acetylsalicylic acid (aspirin) 325 mg daily. Which finding
should alert the PN that the client may be experiencing a side effect of salicylate therapy?
A) Skin tears.
B) Hypothermia.
C) Hepatotoxicity.
D) Gastrointestinal distress. - Correct Answer :D) Gastrointestinal distress.
Feedback:
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
Salicylates, such as aspirin, commonly irritate the gastric mucosa, causing gastrointestinal distress (D). (A, B, and
C) are inaccurate.
The healthcare provider prescribes celecoxib (Celebrex), a nonsteroidal antiinflammatory drug (NSAID), for a
client with osteoarthritis. Which finding in the client's history should the practical nurse (PN) report?
A) Gout.
B) Hypertension.
C) Diabetes mellitus.
D) Peptic-ulcer disease. –
Correct Answer :D) Peptic-ulcer disease.
Feedback:
Celecoxib (Celebrex), an NSAID, causes gastrointestinal irritation and bleeding. Peptic-ulcer disease is a
contraindication to therapy with NSAIDs (D). (A, B, and C) are inaccurate.
What laboratory results should the practical nurse monitor to evaluate the therapeutic effects of heparin?
A) Platelet count.
B) Hematocrit.
C) Prothrombin time (PT).
D) Activated partial thromboplastin time (APTT). –
Correct Answer :D) Activated partial thromboplastin time (APTT).
Feedback:
Ongoing APTT (D) values measure the prolongation times of thromboplastin in the clotting cascade, which is
monitored during heparin therapy. (A, B, and C) do not indicate the therapeutic action of heparin.
Which information should the practical nurse (PN) provide a client who receives a new prescription for a
benzodiazepine medication?
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
A) A list of foods to avoid while taking this prescription.
B) Symptoms that indicate increasing the dose of medication.
C) The interactions of alcohol consumption and CNS depressant drugs.
D) Explanations that support taking a work absence during drug therapy. –
Correct Answer :C) The interactions of alcohol consumption and CNS depressant drugs.
Feedback:
The concomitant use of alcohol and benzodiazepines (C), both CNS depressants, causes an increase in sedation,
which places the client at risk for injury and should be avoided. (A, B, and D) are not indicated.
Which information should the practical nurse (PN) reinforce with a client who is self-administering insulin
injections?
A) Shake the vial of insulin to mix the contents before administration.
B) Store opened vials of insulin in a refrigerator no more than 30 days.
C) Use a different syringe to prepare and inject each type of insulin.
D) Aspirate regular insulin in the syringe first when mixing insulins. -
Correct Answer :D) Aspirate regular insulin in the syringe first when mixing insulins.
Feedback:
When administering two types of insulin, the regular insulin should be prepared first (D) to prevent the
contamination of the regular insulin vial with long-acting insulins. Gently rolling the vial of insulin between the
palms of the hands is recommended, not (A). Opened vials of insulin can be stored at room temperature for 30
days after being opened, and refrigeration (B) is not necessary. Different syringes (C) are not needed when
administering two types of insulin.
What side effect should the practical nurse (PN) report to the healthcare provider for a client who is taking
prednisone (Deltasone)?
A) Dehydration.
B) Hypoglycemia.
P 4
