• PN HESI
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 1 2026 Review Test
Bank | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
The client has been taking omeprazole (Prilosec) for 4 weeks. The ambulatory care nurse evaluates that the
client is receiving optimal intended effect of the medication if the client reports the absence of which symptom?
1. Diarrhea
2. Heartburn
3. Flatulence
4. Constipation - Correct Answer :2. Heartburn
Rationale:
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Omeprazole is a proton pump inhibitor classified as an antiulcer agent. The intended effect of the medication is
relief of pain from gastric irritation, often called heartburn by clients. Omeprazole is not used to treat the
conditions identified in options 1, 3, and 4.
42.) A client with a peptic ulcer is diagnosed with a Helicobacter pylori infection. The nurse is reinforcing teaching
for the client about the medications prescribed, including clarithromycin (Biaxin), esomeprazole (Nexium), and
amoxicillin (Amoxil). Which statement by the client indicates the best understanding of the medication regimen?
1. "My ulcer will heal because these medications will kill the bacteria."
2. "These medications are only taken when I have pain from my ulcer."
3. "The medications will kill the bacteria and stop the acid production."
4. "These medications will coat the ulcer and decrease the acid production in my stomach." - Correct Answer
:3. "The medications will kill the bacteria and stop the acid production."
Rationale:
Triple therapy for Helicobacter pylori infection usually includes two antibacterial drugs and a proton pump
inhibitor. Clarithromycin and amoxicillin are antibacterials. Esomeprazole is a proton pump inhibitor. These
medications will kill the bacteria and decrease acid production.
43.) A histamine (H2)-receptor antagonist will be prescribed for a client. The nurse understands that which
medications are H2-receptor antagonists? Select all that apply.
1. Nizatidine (Axid)
2. Ranitidine (Zantac)
3. Famotidine (Pepcid)
4. Cimetidine (Tagamet)
5. Esomeprazole (Nexium)
6. Lansoprazole (Prevacid) - Correct Answer :1. Nizatidine (Axid)
2. Ranitidine (Zantac)
3. Famotidine (Pepcid)
4. Cimetidine (Tagamet)
Rationale:
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
H2-receptor antagonists suppress secretion of gastric acid, alleviate symptoms of heartburn, and assist in
preventing complications of peptic ulcer disease. These medications also suppress gastric acid secretions and
are used in active ulcer disease, erosive esophagitis, and pathological hypersecretory conditions. The other
medications listed are proton pump inhibitors.
H2-receptor antagonists medication names end with -dine.
Proton pump inhibitors medication names end with -zole.
44.) A client is receiving acetylcysteine (Mucomyst), 20% solution diluted in 0.9% normal saline by nebulizer. The
nurse should have which item available for possible use after giving this medication?
1. Ambu bag
2. Intubation tray
3. Nasogastric tube
4. Suction equipment - Correct Answer :4. Suction equipment
Rationale:
Acetylcysteine can be given orally or by nasogastric tube to treat acetaminophen overdose, or it may be given by
inhalation for use as a mucolytic. The nurse administering this medication as a mucolytic should have suction
equipment available in case the client cannot manage to clear the increased volume of liquefied secretions.
45.) A client has a prescription to take guaifenesin (Humibid) every 4 hours, as needed. The nurse determines
that the client understands the most effective use of this medication if the client states that he or she will:
1. Watch for irritability as a side effect.
2. Take the tablet with a full glass of water.
3. Take an extra dose if the cough is accompanied by fever.
4. Crush the sustained-release tablet if immediate relief is needed. - Correct Answer :2. Take the tablet with a
full glass of water.
Rationale:
Guaifenesin is an expectorant. It should be taken with a full glass of water to decrease viscosity of secretions.
Sustained-release preparations should not be broken open, crushed, or chewed. The medication may
occasionally cause dizziness, headache, or drowsiness as side effects. The client should contact the health care
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
provider if the cough lasts longer than 1 week or is accompanied by fever, rash, sore throat, or persistent
headache.
46.) A postoperative client has received a dose of naloxone hydrochloride for respiratory depression shortly
after transfer to the nursing unit from the postanesthesia care unit. After administration of the medication, the
nurse checks the client for:
1. Pupillary changes
2. Scattered lung wheezes
3. Sudden increase in pain
4. Sudden episodes of diarrhea - Correct Answer :3. Sudden increase in pain
Rationale:
Naloxone hydrochloride is an antidote to opioids and may also be given to the postoperative client to treat
respiratory depression. When given to the postoperative client for respiratory depression, it may also reverse the
effects of analgesics. Therefore, the nurse must check the client for a sudden increase in the level of pain
experienced. Options 1, 2, and 4 are not associated with this medication.
47.) A client has been taking isoniazid (INH) for 2 months. The client complains to a nurse about numbness,
paresthesias, and tingling in the extremities. The nurse interprets that the client is experiencing:
1. Hypercalcemia
2. Peripheral neuritis
3. Small blood vessel spasm
4. Impaired peripheral circulation - Correct Answer :2. Peripheral neuritis
Rationale:
A common side effect of the TB drug INH is peripheral neuritis. This is manifested by numbness, tingling, and
paresthesias in the extremities. This side effect can be minimized by pyridoxine (vitamin B6) intake. Options 1, 3,
and 4 are incorrect.
48.) A client is to begin a 6-month course of therapy with isoniazid (INH). A nurse plans to teach the client to:
1. Drink alcohol in small amounts only.
P 4
Pharmacology 09/11/2026
Exam
PN HESI Pharmacology Exam 1 2026 Review Test
Bank | 180 Questions with Correct Answers &
Detailed Rationales | Evolve HESI PN
Pharmacology Review - Complete A+ Guide
The client has been taking omeprazole (Prilosec) for 4 weeks. The ambulatory care nurse evaluates that the
client is receiving optimal intended effect of the medication if the client reports the absence of which symptom?
1. Diarrhea
2. Heartburn
3. Flatulence
4. Constipation - Correct Answer :2. Heartburn
Rationale:
P 1
, • PN HESI
Pharmacology 09/11/2026
Exam
Omeprazole is a proton pump inhibitor classified as an antiulcer agent. The intended effect of the medication is
relief of pain from gastric irritation, often called heartburn by clients. Omeprazole is not used to treat the
conditions identified in options 1, 3, and 4.
42.) A client with a peptic ulcer is diagnosed with a Helicobacter pylori infection. The nurse is reinforcing teaching
for the client about the medications prescribed, including clarithromycin (Biaxin), esomeprazole (Nexium), and
amoxicillin (Amoxil). Which statement by the client indicates the best understanding of the medication regimen?
1. "My ulcer will heal because these medications will kill the bacteria."
2. "These medications are only taken when I have pain from my ulcer."
3. "The medications will kill the bacteria and stop the acid production."
4. "These medications will coat the ulcer and decrease the acid production in my stomach." - Correct Answer
:3. "The medications will kill the bacteria and stop the acid production."
Rationale:
Triple therapy for Helicobacter pylori infection usually includes two antibacterial drugs and a proton pump
inhibitor. Clarithromycin and amoxicillin are antibacterials. Esomeprazole is a proton pump inhibitor. These
medications will kill the bacteria and decrease acid production.
43.) A histamine (H2)-receptor antagonist will be prescribed for a client. The nurse understands that which
medications are H2-receptor antagonists? Select all that apply.
1. Nizatidine (Axid)
2. Ranitidine (Zantac)
3. Famotidine (Pepcid)
4. Cimetidine (Tagamet)
5. Esomeprazole (Nexium)
6. Lansoprazole (Prevacid) - Correct Answer :1. Nizatidine (Axid)
2. Ranitidine (Zantac)
3. Famotidine (Pepcid)
4. Cimetidine (Tagamet)
Rationale:
P 2
, • PN HESI
Pharmacology 09/11/2026
Exam
H2-receptor antagonists suppress secretion of gastric acid, alleviate symptoms of heartburn, and assist in
preventing complications of peptic ulcer disease. These medications also suppress gastric acid secretions and
are used in active ulcer disease, erosive esophagitis, and pathological hypersecretory conditions. The other
medications listed are proton pump inhibitors.
H2-receptor antagonists medication names end with -dine.
Proton pump inhibitors medication names end with -zole.
44.) A client is receiving acetylcysteine (Mucomyst), 20% solution diluted in 0.9% normal saline by nebulizer. The
nurse should have which item available for possible use after giving this medication?
1. Ambu bag
2. Intubation tray
3. Nasogastric tube
4. Suction equipment - Correct Answer :4. Suction equipment
Rationale:
Acetylcysteine can be given orally or by nasogastric tube to treat acetaminophen overdose, or it may be given by
inhalation for use as a mucolytic. The nurse administering this medication as a mucolytic should have suction
equipment available in case the client cannot manage to clear the increased volume of liquefied secretions.
45.) A client has a prescription to take guaifenesin (Humibid) every 4 hours, as needed. The nurse determines
that the client understands the most effective use of this medication if the client states that he or she will:
1. Watch for irritability as a side effect.
2. Take the tablet with a full glass of water.
3. Take an extra dose if the cough is accompanied by fever.
4. Crush the sustained-release tablet if immediate relief is needed. - Correct Answer :2. Take the tablet with a
full glass of water.
Rationale:
Guaifenesin is an expectorant. It should be taken with a full glass of water to decrease viscosity of secretions.
Sustained-release preparations should not be broken open, crushed, or chewed. The medication may
occasionally cause dizziness, headache, or drowsiness as side effects. The client should contact the health care
P 3
, • PN HESI
Pharmacology 09/11/2026
Exam
provider if the cough lasts longer than 1 week or is accompanied by fever, rash, sore throat, or persistent
headache.
46.) A postoperative client has received a dose of naloxone hydrochloride for respiratory depression shortly
after transfer to the nursing unit from the postanesthesia care unit. After administration of the medication, the
nurse checks the client for:
1. Pupillary changes
2. Scattered lung wheezes
3. Sudden increase in pain
4. Sudden episodes of diarrhea - Correct Answer :3. Sudden increase in pain
Rationale:
Naloxone hydrochloride is an antidote to opioids and may also be given to the postoperative client to treat
respiratory depression. When given to the postoperative client for respiratory depression, it may also reverse the
effects of analgesics. Therefore, the nurse must check the client for a sudden increase in the level of pain
experienced. Options 1, 2, and 4 are not associated with this medication.
47.) A client has been taking isoniazid (INH) for 2 months. The client complains to a nurse about numbness,
paresthesias, and tingling in the extremities. The nurse interprets that the client is experiencing:
1. Hypercalcemia
2. Peripheral neuritis
3. Small blood vessel spasm
4. Impaired peripheral circulation - Correct Answer :2. Peripheral neuritis
Rationale:
A common side effect of the TB drug INH is peripheral neuritis. This is manifested by numbness, tingling, and
paresthesias in the extremities. This side effect can be minimized by pyridoxine (vitamin B6) intake. Options 1, 3,
and 4 are incorrect.
48.) A client is to begin a 6-month course of therapy with isoniazid (INH). A nurse plans to teach the client to:
1. Drink alcohol in small amounts only.
P 4
