Actual Questions & Verified Answers with
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Description
Prepare confidently for the HESI RN Exit Exam V3 with this complete, updated study
guide featuring NGN-style questions and verified rationalized answers .
This resource includes challenging practice questions aligned with the latest NCLEX-RN
test plan, helping you master clinical judgment and boost exam readiness . It covers all core
content areas tested on the exam, with detailed explanations for both correct and incorrect
options to reinforce critical thinking .
Key content areas covered:
Medical-Surgical Nursing – Cardiovascular, respiratory, neurological, renal, and endocrine
disorders
Pharmacology – Drug classifications, adverse effects, interactions, and nursing
considerations
Maternal-Newborn & Pediatrics – Prenatal care, labor and delivery, postpartum, and
growth/development
Mental Health – Psychiatric disorders, therapeutic communication, and
psychopharmacology
, Leadership & Management – Delegation, prioritization, ethics, and quality improvement
Section 1: Medical-Surgical Nursing (Questions 1-80)
1. A patient with heart failure is prescribed furosemide (Lasix). Which laboratory value
should the nurse monitor most closely?
A) Serum sodium
B) Serum potassium
C) Serum calcium
D) Serum magnesium
Correct Answer: B
Rationale: Furosemide is a loop diuretic that causes potassium wasting, leading to
hypokalemia, which increases the risk of digoxin toxicity and arrhythmias .
2. A patient with chronic obstructive pulmonary disease (COPD) has a PaCO2 of 68
mmHg and an SpO2 of 88% on room air. The nurse should administer oxygen at:
A) 2 L/min via nasal cannula
, B) 4 L/min via nasal cannula
C) 6 L/min via simple mask
D) 10 L/min via non-rebreather mask
Correct Answer: A
Rationale: COPD patients with chronic hypercapnia rely on hypoxic drive; high oxygen can
suppress respiratory drive. Target SpO2 is 88-92%, starting at 1-2 L/min .
3. A patient with type 1 diabetes mellitus is found unconscious. The blood glucose
reading is 45 mg/dL. The nurse should first:
A) Administer 50% dextrose IV push
B) Give 15 grams of oral carbohydrate
C) Administer glucagon IM
D) Recheck blood glucose in 15 minutes
Correct Answer: A
Rationale: An unconscious patient cannot swallow safely; IV dextrose is the priority. Glucagon
IM is used if no IV access is available .
4. Which finding in a patient with a new cast on the lower leg is most concerning for
compartment syndrome?
A) Pain that is relieved by elevation
, B) Toes that are pink and warm
C) Pain that worsens with passive extension of the toes
D) Mild swelling around the cast edges
Correct Answer: C
Rationale: Pain out of proportion to injury that worsens with passive stretch is an early sign of
compartment syndrome .
5. A patient with peptic ulcer disease is prescribed omeprazole (Prilosec). The nurse
should instruct the patient to take this medication:
A) With meals
B) 30-60 minutes before breakfast
C) At bedtime with a snack
D) With antacids
Correct Answer: B
Rationale: Proton pump inhibitors like omeprazole are most effective when taken 30-60
minutes before the first meal of the day, allowing the medication to inhibit the proton pumps
activated by eating .
6. A patient with a traumatic brain injury has an intracranial pressure (ICP) of 22 mmHg.
The nurse should: