ONS/ONCC CHEMO RENEWAL EXAM
WITH ACTUAL CORRECT QUESTIONS
AND VERIFIED DETAILED
ANSWERS|FREQUENTLY TESTED
QUESTIONS AND
SOLUTIONS|NEWEST|GUARANTEED
PASS 2026/2027
Sodium thiosulfate
Inject 2 ml of sodium thiosulfate for each milligram of
mechlorethamine extravagated.
Inject subcutaneously into extravasation site using a 25
gauge or smaller needle (change needle with each injection).
Monitor extravasation site according to the institution's
policies and procedures.
Extravasciation Alkylating / Mechlorethamine tx
Apply warm compresses.
Dexamethasone
8 mg twice daily
for 14 days
Extravasciation Alkylating: Oxaliplatin
Totect
Apply ice pack (remove 15
minutes prior to Totect
treatment).
Infusion should be initiated within six hours of extravasation.
Infused over 1-2 hours for three days in an area other
than the extravasation site
The dose recommended is based on the patients' body
surface area.
• Day 1: 1,000 mg/m2
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, • Day 2: 1,000 mg/m2
• Day 3: 500 mg/m
Extravasation Tx: Anthracyclines --- Daunorubicin,
doxorubicin, epirubicin,
idarubicin
Hyaluronidase
Apply warm pack for
15-20 minutes four times
daily the next 24-48
hours and keep extremity
elevated.
Administer 1 ml of hyaluronidase subcutaneously in five
separate injections, each containing 0.2 ml of the solution
using a 25 gauge or smaller needle.
Extravasation Tx: Plant alkaloid Vinblastine, vincristine,
vindesine,
vinorelbine
Apply ice pack for 15-20
minutes four times daily
the first 24 hours.
No known antidote
Extravascation Tx: Taxanes Docetaxel, paclitaxe
include aching and tightness along a peripheral vein above the administration site that occurs as the
drug infuses, as well as potential redness or darkening of the vein without swelling and ulceration. Blood
return is typically present; if not, an infiltration may have occurred
Signs of symptoms of venous irritation:
warm compress
Most sources recommend the application of heat using _______________ to help reduce local
discomfort and the restart of the peripheral IV in a larger vein (Polovich et al., 2014).
irinotecan
The manufacturer of ______________ recommends topical flushing of the skin with sterile water and
application of ice in the event of extravasation of the drug (Pfizer Inc., 2012).
Burning, stinging pain around the administration site, although it is important to note that some
patients do not experience any pain with vesicant extravasation and may in fact experience a feeling of
coolness at the site (Polovich et al., 2014).
2|Page
WITH ACTUAL CORRECT QUESTIONS
AND VERIFIED DETAILED
ANSWERS|FREQUENTLY TESTED
QUESTIONS AND
SOLUTIONS|NEWEST|GUARANTEED
PASS 2026/2027
Sodium thiosulfate
Inject 2 ml of sodium thiosulfate for each milligram of
mechlorethamine extravagated.
Inject subcutaneously into extravasation site using a 25
gauge or smaller needle (change needle with each injection).
Monitor extravasation site according to the institution's
policies and procedures.
Extravasciation Alkylating / Mechlorethamine tx
Apply warm compresses.
Dexamethasone
8 mg twice daily
for 14 days
Extravasciation Alkylating: Oxaliplatin
Totect
Apply ice pack (remove 15
minutes prior to Totect
treatment).
Infusion should be initiated within six hours of extravasation.
Infused over 1-2 hours for three days in an area other
than the extravasation site
The dose recommended is based on the patients' body
surface area.
• Day 1: 1,000 mg/m2
1|Page
, • Day 2: 1,000 mg/m2
• Day 3: 500 mg/m
Extravasation Tx: Anthracyclines --- Daunorubicin,
doxorubicin, epirubicin,
idarubicin
Hyaluronidase
Apply warm pack for
15-20 minutes four times
daily the next 24-48
hours and keep extremity
elevated.
Administer 1 ml of hyaluronidase subcutaneously in five
separate injections, each containing 0.2 ml of the solution
using a 25 gauge or smaller needle.
Extravasation Tx: Plant alkaloid Vinblastine, vincristine,
vindesine,
vinorelbine
Apply ice pack for 15-20
minutes four times daily
the first 24 hours.
No known antidote
Extravascation Tx: Taxanes Docetaxel, paclitaxe
include aching and tightness along a peripheral vein above the administration site that occurs as the
drug infuses, as well as potential redness or darkening of the vein without swelling and ulceration. Blood
return is typically present; if not, an infiltration may have occurred
Signs of symptoms of venous irritation:
warm compress
Most sources recommend the application of heat using _______________ to help reduce local
discomfort and the restart of the peripheral IV in a larger vein (Polovich et al., 2014).
irinotecan
The manufacturer of ______________ recommends topical flushing of the skin with sterile water and
application of ice in the event of extravasation of the drug (Pfizer Inc., 2012).
Burning, stinging pain around the administration site, although it is important to note that some
patients do not experience any pain with vesicant extravasation and may in fact experience a feeling of
coolness at the site (Polovich et al., 2014).
2|Page
