ASCP MLS Exam 2025 | Medical Laboratory Scientist Exam | American
Society for Clinical Pathology (ASCP) | Questions and Correct Answers | Just
Released
Procainamide - (CORRECT ANSWER)-Answer: NAPA
-p. 86-Ant antiarrhythmic drug that has a metabolite with the same drug action
-Procainamide is metabolized to N-Acetylprocainamide (NAPA)
- Must quantify both. Although they have the same drug affect, difference in half- life may cause NAPA
to accumulate in the blood and produce toxic affects even at therapeutic levels of procainamide.
loose clusters of small spherical microconidia, positive urease - (CORRECT ANSWER)-Answer:
Trichophyton mentagrophytes -Trichophyton is the only Dermatophyte with two colony types :
macroconidia and microconidia. - T. mentagrophytes characteristically produce "grapelike clusters" of
microconidia. - Positive in the hair perforation test.
Beta -HCG tumor marker - (CORRECT ANSWER)Answer: chorocarcinoma
-The are are 2 forms of hCG Alpha (common form) and Beta (unique form)
5HIAA 5-hydroxyindoleacetic acid - (CORRECT ANSWER)-Answer: carcinoid tumors -5HIAA: primary
metabolite of serotonin, a chemical substance (neurotransmitter) that transmits messages between
nerve cells. -Large quantities of serotonin and 5-HIAA may be produced by some carcinoid tumors.-
Carcinoid tumors are slow-growing noncancerous or cancerous neuroendocrine masses that can form in
the GI tract, especially in the appendix, and in the lungs.
Proteus vulgaris vs P. mirabilis indole test - (CORRECT ANSWER)P. vulgaris is indole pos. P. mirabilis is
indole neg
Hydatid cyst fluid - (CORRECT ANSWER)used to neutralize Anti-P1 antibody
Antacid overdose - (CORRECT ANSWER)Check pH
, 2
Prolonged PT, PTT, and thrombin after collecting from catheter - (CORRECT ANSWER)heparin
contamination
mixing study that was performed with a prolonged PTT that couldn't be corrected - (CORRECT
ANSWER)DRVVT (Dilute Russell Viper Venom Test)
two pt's ran in duplicate (PT and PTT). The PTT seemed to always be prolonged but PT looked ok -
(CORRECT ANSWER)check the CaCl/phospholipid reagent delivery
Patient is on coumadin therapy, what will be affected - (CORRECT ANSWER)Decreased protein C
Lot's of stomatocytes - (CORRECT ANSWER)Liver disease
Burr cells - (CORRECT ANSWER)Uremia
Picture of target cells with hemoglobin C crystals. The white count was high on instrument 1, so a
second instrument was used with a stronger lysing agent, and the white count was corrected -
(CORRECT ANSWER)anti-lysing target cells are what increased the white count? Erythrocytes containing
hemoglobin C do not lyse normally (sickle cell diseases)
A sodium citrate tube was drawn for a HCT on a pt but the hematocrit was abnormal - (CORRECT
ANSWER)recollect with decreased anticoagulant. high hct (>55%) causes low plasma so you need less
anticoagulant
Question that gives a red blood cells count, HGB, and HCT. I did the rule of 3 and found that the HGB
didn't meet the rule of 3 because it was too high - (CORRECT ANSWER)check for lipemia (elevates HGB)
PBS with an elevated reticulocyte count and howell jolly bodies in the RBC's - (CORRECT ANSWER)-
Answer: howell jolly bodies= DNA= Wright Stain
, 3
-Peppenheimer- Prussian blue stain
-which is not taken up by reticulocytes
-helpful in differentiating the two.
-Reticulocytes=Supravital/ new methylene blue stain
what is composed of DNA? - (CORRECT ANSWER)howell jolly bodies
-wright Stain
what falsely increases ESR - (CORRECT ANSWER)vibration, tilting of tube, higher temps, >1 hr test time,
improper mixing of blood, improper dilution
factors decreasing ESR - (CORRECT ANSWER)Polycythemia, Microcytosis (Hb C), Sickle cells, spherocytes,
Anti-inflammatory medications, Hypogammaglobulinemia, Hypofibrinogenemia (DIC), High WBC count,
Hyperviscosity
Factors increasing ESR - (CORRECT ANSWER)Anemia, Macrocytosis, Female gender, Age >50 years,
Obesity, Pregnancy, Hypercholesterolemia, cancer, multiple myeloma, rouleaux, infections,
inflammation
what falsely decreases ESR - (CORRECT ANSWER)low blood/ room temps, air bubbles, tests <1 hr,
improper mixing of blood, improper dilution
lactic acid collection - (CORRECT ANSWER)separate from serum and put on ice
coefficient of variation - (CORRECT ANSWER)(standard deviation/ mean) X 100
Society for Clinical Pathology (ASCP) | Questions and Correct Answers | Just
Released
Procainamide - (CORRECT ANSWER)-Answer: NAPA
-p. 86-Ant antiarrhythmic drug that has a metabolite with the same drug action
-Procainamide is metabolized to N-Acetylprocainamide (NAPA)
- Must quantify both. Although they have the same drug affect, difference in half- life may cause NAPA
to accumulate in the blood and produce toxic affects even at therapeutic levels of procainamide.
loose clusters of small spherical microconidia, positive urease - (CORRECT ANSWER)-Answer:
Trichophyton mentagrophytes -Trichophyton is the only Dermatophyte with two colony types :
macroconidia and microconidia. - T. mentagrophytes characteristically produce "grapelike clusters" of
microconidia. - Positive in the hair perforation test.
Beta -HCG tumor marker - (CORRECT ANSWER)Answer: chorocarcinoma
-The are are 2 forms of hCG Alpha (common form) and Beta (unique form)
5HIAA 5-hydroxyindoleacetic acid - (CORRECT ANSWER)-Answer: carcinoid tumors -5HIAA: primary
metabolite of serotonin, a chemical substance (neurotransmitter) that transmits messages between
nerve cells. -Large quantities of serotonin and 5-HIAA may be produced by some carcinoid tumors.-
Carcinoid tumors are slow-growing noncancerous or cancerous neuroendocrine masses that can form in
the GI tract, especially in the appendix, and in the lungs.
Proteus vulgaris vs P. mirabilis indole test - (CORRECT ANSWER)P. vulgaris is indole pos. P. mirabilis is
indole neg
Hydatid cyst fluid - (CORRECT ANSWER)used to neutralize Anti-P1 antibody
Antacid overdose - (CORRECT ANSWER)Check pH
, 2
Prolonged PT, PTT, and thrombin after collecting from catheter - (CORRECT ANSWER)heparin
contamination
mixing study that was performed with a prolonged PTT that couldn't be corrected - (CORRECT
ANSWER)DRVVT (Dilute Russell Viper Venom Test)
two pt's ran in duplicate (PT and PTT). The PTT seemed to always be prolonged but PT looked ok -
(CORRECT ANSWER)check the CaCl/phospholipid reagent delivery
Patient is on coumadin therapy, what will be affected - (CORRECT ANSWER)Decreased protein C
Lot's of stomatocytes - (CORRECT ANSWER)Liver disease
Burr cells - (CORRECT ANSWER)Uremia
Picture of target cells with hemoglobin C crystals. The white count was high on instrument 1, so a
second instrument was used with a stronger lysing agent, and the white count was corrected -
(CORRECT ANSWER)anti-lysing target cells are what increased the white count? Erythrocytes containing
hemoglobin C do not lyse normally (sickle cell diseases)
A sodium citrate tube was drawn for a HCT on a pt but the hematocrit was abnormal - (CORRECT
ANSWER)recollect with decreased anticoagulant. high hct (>55%) causes low plasma so you need less
anticoagulant
Question that gives a red blood cells count, HGB, and HCT. I did the rule of 3 and found that the HGB
didn't meet the rule of 3 because it was too high - (CORRECT ANSWER)check for lipemia (elevates HGB)
PBS with an elevated reticulocyte count and howell jolly bodies in the RBC's - (CORRECT ANSWER)-
Answer: howell jolly bodies= DNA= Wright Stain
, 3
-Peppenheimer- Prussian blue stain
-which is not taken up by reticulocytes
-helpful in differentiating the two.
-Reticulocytes=Supravital/ new methylene blue stain
what is composed of DNA? - (CORRECT ANSWER)howell jolly bodies
-wright Stain
what falsely increases ESR - (CORRECT ANSWER)vibration, tilting of tube, higher temps, >1 hr test time,
improper mixing of blood, improper dilution
factors decreasing ESR - (CORRECT ANSWER)Polycythemia, Microcytosis (Hb C), Sickle cells, spherocytes,
Anti-inflammatory medications, Hypogammaglobulinemia, Hypofibrinogenemia (DIC), High WBC count,
Hyperviscosity
Factors increasing ESR - (CORRECT ANSWER)Anemia, Macrocytosis, Female gender, Age >50 years,
Obesity, Pregnancy, Hypercholesterolemia, cancer, multiple myeloma, rouleaux, infections,
inflammation
what falsely decreases ESR - (CORRECT ANSWER)low blood/ room temps, air bubbles, tests <1 hr,
improper mixing of blood, improper dilution
lactic acid collection - (CORRECT ANSWER)separate from serum and put on ice
coefficient of variation - (CORRECT ANSWER)(standard deviation/ mean) X 100
