NURS 660 Exam 1: Psychopharmacology
Overview Questions with Verified Correct
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hyperprolactemia
Higher-than-normal prolactin levels, which may result in spontaneous breastmilk production
and amenorrhea.
Hyperprolactinemia causes
-adenoma
-drugs (SSRI, antipsychotics, cocaine)
-hypothyroidism
-mass effect
-trauma
Hyperprolactinemia Tx
dopamine agonists (cabergoline, bromocriptine)
D2 receptor benefit
Improves positive symptoms
Postural hypotension (orthostatic hypotension)
alpha 1 adrenergic side effect
Sedation
Histamine H1 side effect
What receptors are involved in weight gain?
,5HT2C weight changes + H1 sedation
alpha 1 adrenergic receptor side effects
Orthostatic hypotension
Reflex tachycardia
Dizziness
alpha 2 adrenergic receptors side effect
-Modulates alpha tone
-Counter regulatory for alpha-1 stimulation
-Inhibits norepinephrine
Risk of drug interactions
muscarinic receptors side effect
are normally activated by acetylcholine
ANS response
blurred vision, dry mouth, constipation, urinary retention, tachycardia, memory
D2 antagonism side effects
receptors involved in dopamine transmission
decrease limbic activity
EPS, TD,
endocrine effects-prolactin secretion, sexual dysfunction
increase reward seeking behaviors
5HT2A receptors benefit
Decreased EPS
, 5HT2C benefit
unknown
Histamine H1
Sedation
muscarinic receptor benefit
Decrease EPS
alpha 1 adrenergic receptor benefit
unknown
alpha 2 adrenergic benefit
unknown
What do all antipsychotics have in common?
They reduce dopaminergic neurotransmission.
CYP 450 inducers
Carbamazepine, Phenobarbital, Phenytoin, Rifampin, Griseofulvin
CYP450 inhibitors
CRACK AMIGOS: Cimetidine, Ritonavir (protease inhibitor), Amiodarone, Ciprofloxacin,
Ketoconazole (and other azoles), Acute alcohol use, Macrolides, Isoniazid, Grapefruit Juice,
Omeprazole, Sulfonamides
Volume of distribution (Vd)
Overview Questions with Verified Correct
Answers
hyperprolactemia
Higher-than-normal prolactin levels, which may result in spontaneous breastmilk production
and amenorrhea.
Hyperprolactinemia causes
-adenoma
-drugs (SSRI, antipsychotics, cocaine)
-hypothyroidism
-mass effect
-trauma
Hyperprolactinemia Tx
dopamine agonists (cabergoline, bromocriptine)
D2 receptor benefit
Improves positive symptoms
Postural hypotension (orthostatic hypotension)
alpha 1 adrenergic side effect
Sedation
Histamine H1 side effect
What receptors are involved in weight gain?
,5HT2C weight changes + H1 sedation
alpha 1 adrenergic receptor side effects
Orthostatic hypotension
Reflex tachycardia
Dizziness
alpha 2 adrenergic receptors side effect
-Modulates alpha tone
-Counter regulatory for alpha-1 stimulation
-Inhibits norepinephrine
Risk of drug interactions
muscarinic receptors side effect
are normally activated by acetylcholine
ANS response
blurred vision, dry mouth, constipation, urinary retention, tachycardia, memory
D2 antagonism side effects
receptors involved in dopamine transmission
decrease limbic activity
EPS, TD,
endocrine effects-prolactin secretion, sexual dysfunction
increase reward seeking behaviors
5HT2A receptors benefit
Decreased EPS
, 5HT2C benefit
unknown
Histamine H1
Sedation
muscarinic receptor benefit
Decrease EPS
alpha 1 adrenergic receptor benefit
unknown
alpha 2 adrenergic benefit
unknown
What do all antipsychotics have in common?
They reduce dopaminergic neurotransmission.
CYP 450 inducers
Carbamazepine, Phenobarbital, Phenytoin, Rifampin, Griseofulvin
CYP450 inhibitors
CRACK AMIGOS: Cimetidine, Ritonavir (protease inhibitor), Amiodarone, Ciprofloxacin,
Ketoconazole (and other azoles), Acute alcohol use, Macrolides, Isoniazid, Grapefruit Juice,
Omeprazole, Sulfonamides
Volume of distribution (Vd)
