NUR 2407 PHARMACOLOGY QUIZ 1
COMPREHENSIVE STUDY SET
QUESTIONS AND ANSWERS
1. Which term describes the study of what the body does to a drug, including absorption,
distribution, metabolism, and excretion?
A. Pharmacodynamics
B. Pharmacotherapeutics
C. Pharmacokinetics
D. Pharmacognosy
Answer: C
Conceptual Explanation: Pharmacokinetics refers to the movement of drugs through the
body (Absorption, Distribution, Metabolism, Excretion). Pharmacodynamics is what the
drug does to the body.
2. A patient is taking a drug that has a high first-pass effect. Which route of administration
will result in the lowest bioavailability?
A. Intravenous
,B. Sublingual
C. Rectal
D. Oral
Answer: D
Conceptual Explanation: Oral drugs are absorbed in the GI tract and carried to the liver
via the hepatic portal vein, where they are metabolized before reaching systemic
circulation (first-pass effect).
3. What is the primary site for drug metabolism in the human body?
A. Kidneys
B. Liver
C. Lungs
D. Small Intestine
Answer: B
Conceptual Explanation: The liver is the main organ responsible for the
biotransformation or metabolism of drugs, primarily through the cytochrome P-450
enzyme system.
4. A drug has a half-life of 4 hours. If a patient takes 200mg at 12:00 PM, how much drug will
remain in the body at 8:00 PM?
A. 100 mg
, B. 25 mg
C. 50 mg
D. 0 mg
Answer: C
Conceptual Explanation: After one half-life (4 hours at 4:00 PM), 100mg remains. After a
second half-life (another 4 hours at 8:00 PM), 50mg remains.
5. Which protein is the most important for drug binding in the blood?
A. Hemoglobin
B. Albumin
C. Globulin
D. Fibrinogen
Answer: B
Conceptual Explanation: Albumin is the most common blood protein and the primary
protein to which drugs bind. Only unbound (free) drug is pharmacologically active.
6. A patient with end-stage renal disease is at risk for drug toxicity primarily because of which
pharmacokinetic phase?
A. Absorption
B. Distribution
COMPREHENSIVE STUDY SET
QUESTIONS AND ANSWERS
1. Which term describes the study of what the body does to a drug, including absorption,
distribution, metabolism, and excretion?
A. Pharmacodynamics
B. Pharmacotherapeutics
C. Pharmacokinetics
D. Pharmacognosy
Answer: C
Conceptual Explanation: Pharmacokinetics refers to the movement of drugs through the
body (Absorption, Distribution, Metabolism, Excretion). Pharmacodynamics is what the
drug does to the body.
2. A patient is taking a drug that has a high first-pass effect. Which route of administration
will result in the lowest bioavailability?
A. Intravenous
,B. Sublingual
C. Rectal
D. Oral
Answer: D
Conceptual Explanation: Oral drugs are absorbed in the GI tract and carried to the liver
via the hepatic portal vein, where they are metabolized before reaching systemic
circulation (first-pass effect).
3. What is the primary site for drug metabolism in the human body?
A. Kidneys
B. Liver
C. Lungs
D. Small Intestine
Answer: B
Conceptual Explanation: The liver is the main organ responsible for the
biotransformation or metabolism of drugs, primarily through the cytochrome P-450
enzyme system.
4. A drug has a half-life of 4 hours. If a patient takes 200mg at 12:00 PM, how much drug will
remain in the body at 8:00 PM?
A. 100 mg
, B. 25 mg
C. 50 mg
D. 0 mg
Answer: C
Conceptual Explanation: After one half-life (4 hours at 4:00 PM), 100mg remains. After a
second half-life (another 4 hours at 8:00 PM), 50mg remains.
5. Which protein is the most important for drug binding in the blood?
A. Hemoglobin
B. Albumin
C. Globulin
D. Fibrinogen
Answer: B
Conceptual Explanation: Albumin is the most common blood protein and the primary
protein to which drugs bind. Only unbound (free) drug is pharmacologically active.
6. A patient with end-stage renal disease is at risk for drug toxicity primarily because of which
pharmacokinetic phase?
A. Absorption
B. Distribution
