Nur 641 E Final Exam Study Guide Grand Canyon University(Advanced
Pathophysiology and Actual Questions and Correct Answers
Q1
absorption, distribution, metabolism, excretion
Answer: Pharmacokinetics involves
Q2
absorption from the administrationsite either directly or indirectly in the blood plasma
Answer: Pharmacokinetic absorption
Q3
reversibly or irreversibly move from the bloodstream into the interstitial and intracellular fluid
Answer: Parmacokinetic distribution
Q4
biotransformed via hepaticmetabolism or by other tissue
Answer: Pharmacokinetics metabolism
Q5
highest bioavailability places entire does into venin thus bypassing absorption avoids hepatic first pass
metabolism in the liver
Answer: Intravenous medications
Q6
usually reached within 4-5 half lives of the drug
Answer: steady state medication
Q7
1.the time required for the elimination process to reduce 2.theconcentration of the drug to one half
what it was at initial administration determines drug frequency predicts length of toxic effects constant
first orderpharmacokinetics of a drug
Answer: drug half life
, Q8
drug is metabolized at a constant rate per unit
Answer: zero order (nonlinear)
Q9
metabolizes 50% drugs inhibit: grapefruit juiceincrease drug -> adverse effectsmay have enhanced
activity with any other CYP3A4
Answer: CYP3A4
Q10
discovery or laboratory for development Phase 1 begins with animal testing phase 2 human subjects
compare drug to placebo or other drug that is effective FDA then reviews result and determines
approval Post market study to determineother side effects that were not seen while lab testing
Answer: Six steps in drug development process
Q11
renal calculi
Answer: Comorbid condition in patient with gout
Q12
can initiate an acute gout attack colchcine, NSAIDs or corticosteroids are used with ULTdrugs to
decrease the incidence of ULT induced gout attacks
Answer: Urate lowering therapy
Q13
gout high serum urate levels with underlying renal dysfunction urinary calculi histor of tophaceous gout
Answer: Allupurinol (Zyloprim) Treats
Q14
NSAIDs : indomethacin ibuprofen, naproxen and sulindac
Answer: Acute gout attacks preferred treatment
Q15
GI bleed ( dark stools and epigastric pain) to reduce side effects switch to COX2 inhibitor or Celecoxib
Answer: NSAID side effects
Pathophysiology and Actual Questions and Correct Answers
Q1
absorption, distribution, metabolism, excretion
Answer: Pharmacokinetics involves
Q2
absorption from the administrationsite either directly or indirectly in the blood plasma
Answer: Pharmacokinetic absorption
Q3
reversibly or irreversibly move from the bloodstream into the interstitial and intracellular fluid
Answer: Parmacokinetic distribution
Q4
biotransformed via hepaticmetabolism or by other tissue
Answer: Pharmacokinetics metabolism
Q5
highest bioavailability places entire does into venin thus bypassing absorption avoids hepatic first pass
metabolism in the liver
Answer: Intravenous medications
Q6
usually reached within 4-5 half lives of the drug
Answer: steady state medication
Q7
1.the time required for the elimination process to reduce 2.theconcentration of the drug to one half
what it was at initial administration determines drug frequency predicts length of toxic effects constant
first orderpharmacokinetics of a drug
Answer: drug half life
, Q8
drug is metabolized at a constant rate per unit
Answer: zero order (nonlinear)
Q9
metabolizes 50% drugs inhibit: grapefruit juiceincrease drug -> adverse effectsmay have enhanced
activity with any other CYP3A4
Answer: CYP3A4
Q10
discovery or laboratory for development Phase 1 begins with animal testing phase 2 human subjects
compare drug to placebo or other drug that is effective FDA then reviews result and determines
approval Post market study to determineother side effects that were not seen while lab testing
Answer: Six steps in drug development process
Q11
renal calculi
Answer: Comorbid condition in patient with gout
Q12
can initiate an acute gout attack colchcine, NSAIDs or corticosteroids are used with ULTdrugs to
decrease the incidence of ULT induced gout attacks
Answer: Urate lowering therapy
Q13
gout high serum urate levels with underlying renal dysfunction urinary calculi histor of tophaceous gout
Answer: Allupurinol (Zyloprim) Treats
Q14
NSAIDs : indomethacin ibuprofen, naproxen and sulindac
Answer: Acute gout attacks preferred treatment
Q15
GI bleed ( dark stools and epigastric pain) to reduce side effects switch to COX2 inhibitor or Celecoxib
Answer: NSAID side effects
