NUR 641E Midterm Study Guide Actual Questions and Correct
Answers
Q1
Bioavailability
Answer: the rate at and the extent to which a nutrient is absorbed and used
Q2
Steady state (of a drug)
Answer: stable level of drug in the body, occurs in 5 half lives of the drug
Q3
Pharmacokinetics
Answer: The process by which drugs are absorbed, distributed within the body, metabolized, and
excreted
Q4
First pass
Answer: the fact that a medication in the GI tract passes through the liver before entering other
organs
Q5
Bioequivalence
Answer: relative therapeutic effectiveness of chemically equivalent drugs
Q6
Bioavailability (is affected by)
Answer: chemical instability
Q7
cytochrome p450 inducer
Answer: An inducer increases the metabolism of a substrate resulting in a decreased level or
effect of the
substrate
, Q8
cytochrome p450 inhibitor
Answer: An inhibitor decreases the metabolism of a substrate resulting in an increased level or
effect of the
substrate
Q9
Clopidogrel
Answer: prodrug that must be activated by hepatic CYP2C19 metabolism; individuals who are
poor metabolizers
may not form the active metabolite and have reduced antiplatelet response
Q10
half-life (determines)
Answer: how often a drug is administered
Q11
Warfarin (MOA)
Answer: Vitamin K antagonist
Q12
Heparin (MOA)
Answer: rapid anticoagulation by binding with antithrombin III and inhibits factors IXa, Xa, XIIa,
and XIII
Q13
Apixaban (MOA)
Answer: direct factor Xa inhibitor
Q14
parenteral administration
Answer: directly into systemic circulation
Q15
inhalation
Answer: drug effects as rapid as IV bolus
Answers
Q1
Bioavailability
Answer: the rate at and the extent to which a nutrient is absorbed and used
Q2
Steady state (of a drug)
Answer: stable level of drug in the body, occurs in 5 half lives of the drug
Q3
Pharmacokinetics
Answer: The process by which drugs are absorbed, distributed within the body, metabolized, and
excreted
Q4
First pass
Answer: the fact that a medication in the GI tract passes through the liver before entering other
organs
Q5
Bioequivalence
Answer: relative therapeutic effectiveness of chemically equivalent drugs
Q6
Bioavailability (is affected by)
Answer: chemical instability
Q7
cytochrome p450 inducer
Answer: An inducer increases the metabolism of a substrate resulting in a decreased level or
effect of the
substrate
, Q8
cytochrome p450 inhibitor
Answer: An inhibitor decreases the metabolism of a substrate resulting in an increased level or
effect of the
substrate
Q9
Clopidogrel
Answer: prodrug that must be activated by hepatic CYP2C19 metabolism; individuals who are
poor metabolizers
may not form the active metabolite and have reduced antiplatelet response
Q10
half-life (determines)
Answer: how often a drug is administered
Q11
Warfarin (MOA)
Answer: Vitamin K antagonist
Q12
Heparin (MOA)
Answer: rapid anticoagulation by binding with antithrombin III and inhibits factors IXa, Xa, XIIa,
and XIII
Q13
Apixaban (MOA)
Answer: direct factor Xa inhibitor
Q14
parenteral administration
Answer: directly into systemic circulation
Q15
inhalation
Answer: drug effects as rapid as IV bolus
