EXAM 2
Advanced Pharmacology
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Wilkes University
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,Table of Contents
NSG 533 Exam 2 ................................................................................ 2
NSG 533 Exam 2 ............................................................................. 40
NSG 533 Exam 2 Study Guide ................................................. 69
NSG 533 Exam 2
1. What would you be concerned with regarding the first patient's use of Vicodin in
terms of the dose of acetaminophen?
A) The patient may develop renal toxicity from acetaminophen overdose.
B) In elderly patients, it is recommended not to exceed >3,000 mg per day of
acetaminophen.
C) Acetaminophen causes significant gastrointestinal bleeding in elderly patients.
D) Vicodin contains no acetaminophen, so there is no concern.
Correct Answer: B
Rationale: Vicodin is a combination medication containing hydrocodone and
acetaminophen. In elderly patients, the recommended maximum daily dose of
acetaminophen is 3,000 mg to reduce the risk of hepatotoxicity. Many patients may
unknowingly exceed this limit by taking multiple medications containing acetaminophen
(APAP). The FDA has set a maximum daily dose of 4,000 mg for the general population,
but geriatric patients and those with liver disease should not exceed 3,000 mg/day.
, Acetaminophen does not cause significant GI bleeding (that's NSAIDs), and Vicodin
definitely contains acetaminophen.
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2. What medication could you recommend for a diabetic patient in pain that could also
be used to help treat depression?
A) Gabapentin
B) Duloxetine or venlafaxine
C) Tramadol
D) Amitriptyline
Correct Answer: B
Rationale: SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors), specifically duloxetine
and venlafaxine, are dual-purpose medications. They are FDA-approved for the
treatment of diabetic peripheral neuropathic pain and are also effective antidepressants.
Duloxetine is particularly beneficial because it addresses both the neuropathic pain
common in diabetes and comorbid depression. Gabapentin treats neuropathic pain but
is not an antidepressant. Tramadol is an opioid analgesic with weak SSRI/SNRI
properties but is not indicated for depression. Amitriptyline is a TCA that can treat both
conditions but is not the best answer here as the question specifically asks about SNRIs.
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