EXAM 3
Advanced Pharmacology
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Wilkes University
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,Table of Contents
NSG 533 Exam 3 ................................................................................ 2
NSG 533 Exam 3 ............................................................................. 26
NSG 533 Exam 3 Focused Study Guide .............................. 49
NSG 533 Exam 3
Question 1
A 28-year-old patient with moderate persistent asthma is prescribed an inhaled
corticosteroid (ICS). Which of the following best describes the mechanism of action of
ICS?
A) Stimulate beta-2 adrenergic receptors causing bronchodilation
B) Inhibit acetylcholine on muscarinic receptors to prevent bronchoconstriction
C) Potent anti-inflammatory agents that decrease airway inflammation, attenuate airway
hyper-responsiveness, and minimize mucus production
D) Block leukotriene receptors to reduce bronchoconstriction
Correct Answer: C
Rationale: Inhaled corticosteroids (ICS) such as fluticasone, budesonide,
beclomethasone, and ciclesonide are the most potent anti-inflammatory agents for
asthma. They work by decreasing airway inflammation, attenuating airway hyper-
responsiveness, and minimizing mucus production and secretions. They also improve
the actions of beta-agonists and target the lungs directly. Option A describes LABA
mechanism, Option B describes LAMA mechanism, and Option D describes LTRA
mechanism.
, Question 2
Which of the following are examples of inhaled corticosteroids? (Select All That Apply)
A) Fluticasone
B) Salmeterol
C) Budesonide
D) Tiotropium
E) Beclomethasone
F) Ciclesonide
Correct Answers: A, C, E, F
Rationale: Fluticasone, budesonide, beclomethasone, and ciclesonide are all inhaled
corticosteroids. Salmeterol (Option B) is a long-acting beta agonist (LABA), and
tiotropium (Option D) is a long-acting muscarinic antagonist (LAMA). It is critical to
distinguish between drug classes for safe prescribing.
Question 3
A patient with asthma not adequately controlled on an inhaled corticosteroid alone is
prescribed a long-acting beta agonist (LABA) as add-on therapy. What is the primary
mechanism of action of LABA?
A) Inhibit 5-lipoxygenase to reduce leukotriene production
B) Stimulate beta-2 adrenergic receptors in the lungs, resulting in relaxation of bronchial
smooth muscle (bronchodilation)
C) Block muscarinic receptors to prevent cholinergic bronchoconstriction
D) Stabilize mast cell membranes to prevent degranulation
Correct Answer: B
Rationale: Long-acting beta agonists (LABA) such as salmeterol and vilanterol work by
stimulating beta-2 adrenergic receptors in the lungs, resulting in relaxation of bronchial
smooth muscle (bronchodilation). Benefits include improved pulmonary function, more
symptom-free days, and decreased need for short-acting beta agonists (SABA). LABA
should NEVER be used as monotherapy for asthma—must always be combined with