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NCLEX-PN Questions & Answers 2026-
2027 | Latest Comprehensive Nursing
Review (Rationales)
Document Overview
This comprehensive nursing review provides 184 NCLEX-PN style questions, each with its
correct answer and detailed rationales. It covers a broad spectrum of essential nursing
knowledge, making it an invaluable resource for in-depth study and effective certification
preparation. This document is ideal for students seeking to solidify their understanding
and readiness for the NCLEX-PN exam.
100% Accurate Questions and Answers 100% Guarantee Pass - Verified by Experts
Expert-Verified
Verified Answers · Detailed Rationales · 184 Questions · September 2026
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
, Topics Covered
Section 1: Pharmacology & Drug Actions
Questions covering pharmacology & Drug Actions concepts.
Section 2: Respiratory System
Questions covering respiratory System concepts.
Section 3: Fluid & Electrolyte Balance
Questions covering fluid & Electrolyte Balance concepts.
Section 4: Endocrine & Metabolic
Questions covering endocrine & Metabolic concepts.
Section 5: Integumentary & Wound Care
Questions covering integumentary & Wound Care concepts.
Section 6: Neurological & Musculoskeletal
Questions covering neurological & Musculoskeletal concepts.
Section 7: Gastrointestinal & Nutrition
Questions covering gastrointestinal & Nutrition concepts.
Section 8: Nursing Fundamentals & Process
Questions covering nursing Fundamentals & Process concepts.
Section 9: Cardiovascular System
Questions covering cardiovascular System concepts.
Section 10: Reproductive & Genitourinary
Questions covering reproductive & Genitourinary concepts.
Questions
QUESTION 1 OF 184
What is the medication "Tigan" used for?
Correct Answer: Nausea and Emesis
Rationale: Tigan, the brand name for trimethobenzamide, is an antiemetic medication. Its mechanism of action
involves inhibiting the chemoreceptor trigger zone (CTZ) in the brainstem, which plays a role in the vomiting reflex.
Therefore, Tigan is prescribed to manage and prevent nausea and emesis.
QUESTION 2 OF 184
What is an EARLY sign of digoxin toxicity, from the drug digoxin?
Correct Answer: Anorexia
Rationale: Digoxin toxicity affects the gastrointestinal system early due to its direct action on the chemoreceptor
trigger zone, leading to nausea and anorexia. Anorexia, or loss of appetite, is a common and often the first
manifestation of developing digoxin toxicity. This symptom signals the need for immediate assessment and potential
intervention.
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
, QUESTION 3 OF 184
How soon after the administration of nitroglycerin should the patient see relief?
Correct Answer: 5 mins
(Burning sensation/vertigo are common side effects)
Rationale: Nitroglycerin, administered sublingually for angina, is rapidly absorbed and begins to exert its
vasodilatory effects quickly. Patients typically experience relief from chest pain within 5 minutes as the medication
dilates coronary arteries. The mention of burning sensation and vertigo serves as a reminder of common, transient
side effects associated with its rapid action. This aligns with 5 mins (Burning sensation/vertigo are common side
effects), (Burning sensation/vertigo are common side effects) and sensation/vertigo.
QUESTION 4 OF 184
What is a concern when a patient is taking Warfarin?
Correct Answer: Bleeding easily
(Educate patient on straight razor use)
Rationale: Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors, increasing the risk of
hemorrhage. Patients taking warfarin must be educated on signs of bleeding and to avoid activities or products that
can exacerbate this risk, such as using a straight razor. Therefore, bleeding easily is a primary concern for patients on
warfarin therapy. This aligns with Bleeding easily (Educate patient on straight razor use), (Educate patient on
straight razor use) and Bleeding easily.
QUESTION 5 OF 184
Iron supplements should be taken with what?
Correct Answer: Vitamin C rich juices (Tomato juice, Orange juice)
Rationale: Vitamin C enhances the absorption of non-heme iron, which is the type of iron found in plant-based foods
and iron supplements. Therefore, taking iron supplements with Vitamin C-rich juices like tomato or orange juice
optimizes the body's ability to absorb the iron. This nutritional synergy is a key principle in managing iron deficiency
anemia. This aligns with Vitamin C rich juices (Tomato juice, Orange juice), Vitamin C rich juices (Tomato juice and
Orange juice).
QUESTION 6 OF 184
Drugs that end in "lol" are normally used for what?
Correct Answer: Beta Blocker (for hypertension) ("Lo" Lowers the BP)
Rationale: Drugs with the suffix "-lol" are classified as beta-adrenergic blocking agents, commonly known as beta-
blockers. These medications are frequently prescribed to manage hypertension by reducing heart rate and
contractility, thereby lowering blood pressure. The mnemonic "Lo" in the suffix helps remember their function in
lowering blood pressure. This aligns with Beta Blocker (for hypertension) ("Lo" Lowers the BP).
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
, QUESTION 7 OF 184
What OTC tabs should patients not take with medication?
Correct Answer: Antacids tabs (effects the absorption of the med)
Rationale: Antacids tabs (effects the absorption of the med), particularly in tablet form, can alter gastrointestinal pH
and bind to certain medications, thereby impairing their absorption. This interference can lead to reduced therapeutic
efficacy of the prescribed medication. Therefore, patients should be advised to avoid taking antacid tablets
concurrently with their prescribed medications unless specifically directed by a healthcare provider.
QUESTION 8 OF 184
Which tabs should not be crushed?
Correct Answer: Enteric Coated/sustained release tabs
Rationale: Enteric-coated tablets are designed to bypass stomach acid and dissolve in the small intestine, while
sustained-release tablets are formulated to release medication slowly over time. Crushing these dosage forms would
destroy their protective coatings or alter their release mechanisms, potentially leading to rapid drug absorption,
increased risk of adverse effects, or reduced therapeutic efficacy. Therefore, these specific tablet types should not be
crushed to maintain their intended pharmacokinetic profiles. This aligns with Enteric Coated/sustained release tabs
and Coated/sustained.
QUESTION 9 OF 184
Can nurses adjust or change a patients medication?
Correct Answer: NO (only the Doctor can do this)
Rationale: The authority to prescribe and modify medication regimens rests with licensed medical practitioners, such
as physicians, who possess the legal and clinical purview to diagnose, treat, and manage patient conditions. Licensed
Practical Nurses (LPNs) operate under the supervision of registered nurses and physicians and are authorized to
administer medications as prescribed but cannot independently alter dosages, frequencies, or types of medication. This
scope of practice is critical for patient safety and adherence to regulatory standards in nursing. This aligns with NO
(only the Doctor can do this).
QUESTION 10 OF 184
T/F Patients should consult a doctor before taking OTC or any herbal preparations?
Correct Answer: True
Rationale: Over-the-counter (OTC) medications and herbal preparations can interact with prescription drugs or
exacerbate existing health conditions. Consulting a healthcare provider ensures these substances are safe and
appropriate for the individual's specific medical profile. This consultation prevents potential adverse effects and
maintains therapeutic efficacy. This aligns with True.
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
NCLEX-PN Questions & Answers 2026-
2027 | Latest Comprehensive Nursing
Review (Rationales)
Document Overview
This comprehensive nursing review provides 184 NCLEX-PN style questions, each with its
correct answer and detailed rationales. It covers a broad spectrum of essential nursing
knowledge, making it an invaluable resource for in-depth study and effective certification
preparation. This document is ideal for students seeking to solidify their understanding
and readiness for the NCLEX-PN exam.
100% Accurate Questions and Answers 100% Guarantee Pass - Verified by Experts
Expert-Verified
Verified Answers · Detailed Rationales · 184 Questions · September 2026
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
, Topics Covered
Section 1: Pharmacology & Drug Actions
Questions covering pharmacology & Drug Actions concepts.
Section 2: Respiratory System
Questions covering respiratory System concepts.
Section 3: Fluid & Electrolyte Balance
Questions covering fluid & Electrolyte Balance concepts.
Section 4: Endocrine & Metabolic
Questions covering endocrine & Metabolic concepts.
Section 5: Integumentary & Wound Care
Questions covering integumentary & Wound Care concepts.
Section 6: Neurological & Musculoskeletal
Questions covering neurological & Musculoskeletal concepts.
Section 7: Gastrointestinal & Nutrition
Questions covering gastrointestinal & Nutrition concepts.
Section 8: Nursing Fundamentals & Process
Questions covering nursing Fundamentals & Process concepts.
Section 9: Cardiovascular System
Questions covering cardiovascular System concepts.
Section 10: Reproductive & Genitourinary
Questions covering reproductive & Genitourinary concepts.
Questions
QUESTION 1 OF 184
What is the medication "Tigan" used for?
Correct Answer: Nausea and Emesis
Rationale: Tigan, the brand name for trimethobenzamide, is an antiemetic medication. Its mechanism of action
involves inhibiting the chemoreceptor trigger zone (CTZ) in the brainstem, which plays a role in the vomiting reflex.
Therefore, Tigan is prescribed to manage and prevent nausea and emesis.
QUESTION 2 OF 184
What is an EARLY sign of digoxin toxicity, from the drug digoxin?
Correct Answer: Anorexia
Rationale: Digoxin toxicity affects the gastrointestinal system early due to its direct action on the chemoreceptor
trigger zone, leading to nausea and anorexia. Anorexia, or loss of appetite, is a common and often the first
manifestation of developing digoxin toxicity. This symptom signals the need for immediate assessment and potential
intervention.
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
, QUESTION 3 OF 184
How soon after the administration of nitroglycerin should the patient see relief?
Correct Answer: 5 mins
(Burning sensation/vertigo are common side effects)
Rationale: Nitroglycerin, administered sublingually for angina, is rapidly absorbed and begins to exert its
vasodilatory effects quickly. Patients typically experience relief from chest pain within 5 minutes as the medication
dilates coronary arteries. The mention of burning sensation and vertigo serves as a reminder of common, transient
side effects associated with its rapid action. This aligns with 5 mins (Burning sensation/vertigo are common side
effects), (Burning sensation/vertigo are common side effects) and sensation/vertigo.
QUESTION 4 OF 184
What is a concern when a patient is taking Warfarin?
Correct Answer: Bleeding easily
(Educate patient on straight razor use)
Rationale: Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors, increasing the risk of
hemorrhage. Patients taking warfarin must be educated on signs of bleeding and to avoid activities or products that
can exacerbate this risk, such as using a straight razor. Therefore, bleeding easily is a primary concern for patients on
warfarin therapy. This aligns with Bleeding easily (Educate patient on straight razor use), (Educate patient on
straight razor use) and Bleeding easily.
QUESTION 5 OF 184
Iron supplements should be taken with what?
Correct Answer: Vitamin C rich juices (Tomato juice, Orange juice)
Rationale: Vitamin C enhances the absorption of non-heme iron, which is the type of iron found in plant-based foods
and iron supplements. Therefore, taking iron supplements with Vitamin C-rich juices like tomato or orange juice
optimizes the body's ability to absorb the iron. This nutritional synergy is a key principle in managing iron deficiency
anemia. This aligns with Vitamin C rich juices (Tomato juice, Orange juice), Vitamin C rich juices (Tomato juice and
Orange juice).
QUESTION 6 OF 184
Drugs that end in "lol" are normally used for what?
Correct Answer: Beta Blocker (for hypertension) ("Lo" Lowers the BP)
Rationale: Drugs with the suffix "-lol" are classified as beta-adrenergic blocking agents, commonly known as beta-
blockers. These medications are frequently prescribed to manage hypertension by reducing heart rate and
contractility, thereby lowering blood pressure. The mnemonic "Lo" in the suffix helps remember their function in
lowering blood pressure. This aligns with Beta Blocker (for hypertension) ("Lo" Lowers the BP).
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
, QUESTION 7 OF 184
What OTC tabs should patients not take with medication?
Correct Answer: Antacids tabs (effects the absorption of the med)
Rationale: Antacids tabs (effects the absorption of the med), particularly in tablet form, can alter gastrointestinal pH
and bind to certain medications, thereby impairing their absorption. This interference can lead to reduced therapeutic
efficacy of the prescribed medication. Therefore, patients should be advised to avoid taking antacid tablets
concurrently with their prescribed medications unless specifically directed by a healthcare provider.
QUESTION 8 OF 184
Which tabs should not be crushed?
Correct Answer: Enteric Coated/sustained release tabs
Rationale: Enteric-coated tablets are designed to bypass stomach acid and dissolve in the small intestine, while
sustained-release tablets are formulated to release medication slowly over time. Crushing these dosage forms would
destroy their protective coatings or alter their release mechanisms, potentially leading to rapid drug absorption,
increased risk of adverse effects, or reduced therapeutic efficacy. Therefore, these specific tablet types should not be
crushed to maintain their intended pharmacokinetic profiles. This aligns with Enteric Coated/sustained release tabs
and Coated/sustained.
QUESTION 9 OF 184
Can nurses adjust or change a patients medication?
Correct Answer: NO (only the Doctor can do this)
Rationale: The authority to prescribe and modify medication regimens rests with licensed medical practitioners, such
as physicians, who possess the legal and clinical purview to diagnose, treat, and manage patient conditions. Licensed
Practical Nurses (LPNs) operate under the supervision of registered nurses and physicians and are authorized to
administer medications as prescribed but cannot independently alter dosages, frequencies, or types of medication. This
scope of practice is critical for patient safety and adherence to regulatory standards in nursing. This aligns with NO
(only the Doctor can do this).
QUESTION 10 OF 184
T/F Patients should consult a doctor before taking OTC or any herbal preparations?
Correct Answer: True
Rationale: Over-the-counter (OTC) medications and herbal preparations can interact with prescription drugs or
exacerbate existing health conditions. Consulting a healthcare provider ensures these substances are safe and
appropriate for the individual's specific medical profile. This consultation prevents potential adverse effects and
maintains therapeutic efficacy. This aligns with True.
NCLEX-PN Questions & Answers 2026-2027 | Latest Comprehensive Nursing Review (Rationales) - Practice Questions Page 0
