NSG 533 advanced pharm exam 2 Latest 2026/2027 guide with complete
solution/Advanced Pharmacology Final Exam Questions and Answers(100%
Verified)
Course
NSG 533
1. Opioid Safety
A patient takes hydrocodone/acetaminophen for chronic pain. Which assessment is most
important when determining the patient's total acetaminophen exposure?
A. Total amount of caffeine consumed
B. Acetaminophen from all prescription and OTC products
C. Daily sodium intake
D. Amount of dietary calcium
Answer: B. Acetaminophen from all prescription and OTC products
Complete solution:
Combination opioid products may contain acetaminophen. The clinician must calculate the
patient's total daily acetaminophen exposure from all sources to reduce the risk of
hepatotoxicity. Older adults and patients with liver disease, alcohol-related risk, or prolonged
exposure require particularly careful assessment.
2. Neuropathic Pain
Which medication is an appropriate nonopioid option for neuropathic pain?
A. Gabapentin
B. Acetaminophen only
C. Naloxone
D. Aspirin only
Answer: A. Gabapentin
Rationale:
Gabapentin is commonly used for neuropathic pain. Other options may include pregabalin,
selected antidepressants such as duloxetine, and topical lidocaine depending on the condition.
3. Diabetic Neuropathy and Depression
,A patient with diabetic peripheral neuropathy also has depression. Which medication may
address both conditions?
A. Duloxetine
B. Naloxone
C. Diphenhydramine
D. Omeprazole
Answer: A. Duloxetine
Complete solution:
Duloxetine is an SNRI that can treat depression and is also approved for certain neuropathic
pain conditions, including diabetic peripheral neuropathic pain.
4. Opioid Adverse Effect
Which adverse effect is most characteristic of opioid therapy?
A. Constipation
B. Severe diarrhea
C. Hyperactivity
D. Increased bowel motility
Answer: A. Constipation
Rationale:
Opioids decrease gastrointestinal motility and commonly cause constipation. Unlike some other
opioid adverse effects, tolerance to constipation generally does not develop reliably, so
preventive bowel management is often needed.
5. Opioid Overdose
A patient receiving morphine becomes extremely sedated with respiratory depression. Which
medication reverses opioid-induced respiratory depression?
A. Flumazenil
B. Naloxone
C. Atropine
D. Protamine
Answer: B. Naloxone
,Complete solution:
Naloxone is an opioid antagonist that rapidly reverses opioid effects, particularly respiratory
depression. Because its duration may be shorter than that of some opioids, repeated dosing or
continued monitoring may be necessary.
6. True Opioid Allergy
A patient has a documented severe immediate hypersensitivity reaction to morphine. Which
approach is most appropriate?
A. Automatically administer another opioid without assessment
B. Verify the reaction and consider an opioid from an appropriate alternative class if opioid
therapy is necessary
C. Increase the morphine dose
D. Add acetaminophen and continue morphine
Answer: B. Verify the reaction and consider an opioid from an appropriate alternative class if
opioid therapy is necessary
Rationale:
True opioid allergy is uncommon, while nonimmune histamine-mediated reactions can mimic
allergy. A genuine severe allergy requires careful assessment and selection of an appropriate
alternative, potentially with specialist input.
7. Migraine Prophylaxis
A patient with asthma requires preventive migraine therapy. Which medication class may be
problematic?
A. Beta blockers
B. Calcium supplements
C. Proton-pump inhibitors
D. Antacids
Answer: A. Beta blockers
Complete solution:
Nonselective beta blockers can cause bronchoconstriction and may worsen asthma. Migraine
prophylaxis should therefore be individualized based on comorbidities.
, 8. Acute Migraine
Which medication class is commonly used as first-line specific therapy for moderate-to-severe
acute migraine when not contraindicated?
A. Triptans
B. Statins
C. ACE inhibitors
D. Bisphosphonates
Answer: A. Triptans
Rationale:
Triptans are serotonin 5-HT1B/1D receptor agonists used for acute migraine treatment. They are
not appropriate for every patient, particularly those with certain cardiovascular or
cerebrovascular conditions.
9. Triptan Contraindication
Which patient should generally avoid triptan therapy?
A. Patient with established coronary artery disease
B. Patient with seasonal allergies
C. Patient with mild acne
D. Patient with uncomplicated myopia
Answer: A. Patient with established coronary artery disease
Complete solution:
Triptans cause cranial vasoconstriction and are contraindicated in patients with certain
cardiovascular and cerebrovascular diseases. A careful cardiovascular history is essential before
prescribing.
10. Beta-Blocker Pharmacodynamics
A patient taking a beta-1 selective blocker develops a significant reduction in heart rate. Which
pharmacologic effect explains this?
A. Increased beta-1 stimulation
B. Reduced sympathetic stimulation of the heart
C. Increased alpha-1 activation
D. Increased calcium absorption
solution/Advanced Pharmacology Final Exam Questions and Answers(100%
Verified)
Course
NSG 533
1. Opioid Safety
A patient takes hydrocodone/acetaminophen for chronic pain. Which assessment is most
important when determining the patient's total acetaminophen exposure?
A. Total amount of caffeine consumed
B. Acetaminophen from all prescription and OTC products
C. Daily sodium intake
D. Amount of dietary calcium
Answer: B. Acetaminophen from all prescription and OTC products
Complete solution:
Combination opioid products may contain acetaminophen. The clinician must calculate the
patient's total daily acetaminophen exposure from all sources to reduce the risk of
hepatotoxicity. Older adults and patients with liver disease, alcohol-related risk, or prolonged
exposure require particularly careful assessment.
2. Neuropathic Pain
Which medication is an appropriate nonopioid option for neuropathic pain?
A. Gabapentin
B. Acetaminophen only
C. Naloxone
D. Aspirin only
Answer: A. Gabapentin
Rationale:
Gabapentin is commonly used for neuropathic pain. Other options may include pregabalin,
selected antidepressants such as duloxetine, and topical lidocaine depending on the condition.
3. Diabetic Neuropathy and Depression
,A patient with diabetic peripheral neuropathy also has depression. Which medication may
address both conditions?
A. Duloxetine
B. Naloxone
C. Diphenhydramine
D. Omeprazole
Answer: A. Duloxetine
Complete solution:
Duloxetine is an SNRI that can treat depression and is also approved for certain neuropathic
pain conditions, including diabetic peripheral neuropathic pain.
4. Opioid Adverse Effect
Which adverse effect is most characteristic of opioid therapy?
A. Constipation
B. Severe diarrhea
C. Hyperactivity
D. Increased bowel motility
Answer: A. Constipation
Rationale:
Opioids decrease gastrointestinal motility and commonly cause constipation. Unlike some other
opioid adverse effects, tolerance to constipation generally does not develop reliably, so
preventive bowel management is often needed.
5. Opioid Overdose
A patient receiving morphine becomes extremely sedated with respiratory depression. Which
medication reverses opioid-induced respiratory depression?
A. Flumazenil
B. Naloxone
C. Atropine
D. Protamine
Answer: B. Naloxone
,Complete solution:
Naloxone is an opioid antagonist that rapidly reverses opioid effects, particularly respiratory
depression. Because its duration may be shorter than that of some opioids, repeated dosing or
continued monitoring may be necessary.
6. True Opioid Allergy
A patient has a documented severe immediate hypersensitivity reaction to morphine. Which
approach is most appropriate?
A. Automatically administer another opioid without assessment
B. Verify the reaction and consider an opioid from an appropriate alternative class if opioid
therapy is necessary
C. Increase the morphine dose
D. Add acetaminophen and continue morphine
Answer: B. Verify the reaction and consider an opioid from an appropriate alternative class if
opioid therapy is necessary
Rationale:
True opioid allergy is uncommon, while nonimmune histamine-mediated reactions can mimic
allergy. A genuine severe allergy requires careful assessment and selection of an appropriate
alternative, potentially with specialist input.
7. Migraine Prophylaxis
A patient with asthma requires preventive migraine therapy. Which medication class may be
problematic?
A. Beta blockers
B. Calcium supplements
C. Proton-pump inhibitors
D. Antacids
Answer: A. Beta blockers
Complete solution:
Nonselective beta blockers can cause bronchoconstriction and may worsen asthma. Migraine
prophylaxis should therefore be individualized based on comorbidities.
, 8. Acute Migraine
Which medication class is commonly used as first-line specific therapy for moderate-to-severe
acute migraine when not contraindicated?
A. Triptans
B. Statins
C. ACE inhibitors
D. Bisphosphonates
Answer: A. Triptans
Rationale:
Triptans are serotonin 5-HT1B/1D receptor agonists used for acute migraine treatment. They are
not appropriate for every patient, particularly those with certain cardiovascular or
cerebrovascular conditions.
9. Triptan Contraindication
Which patient should generally avoid triptan therapy?
A. Patient with established coronary artery disease
B. Patient with seasonal allergies
C. Patient with mild acne
D. Patient with uncomplicated myopia
Answer: A. Patient with established coronary artery disease
Complete solution:
Triptans cause cranial vasoconstriction and are contraindicated in patients with certain
cardiovascular and cerebrovascular diseases. A careful cardiovascular history is essential before
prescribing.
10. Beta-Blocker Pharmacodynamics
A patient taking a beta-1 selective blocker develops a significant reduction in heart rate. Which
pharmacologic effect explains this?
A. Increased beta-1 stimulation
B. Reduced sympathetic stimulation of the heart
C. Increased alpha-1 activation
D. Increased calcium absorption
