MMSC 436 EXAM 1 ALL QUESTIONS WITH VERIFIED
ANSWERS
What are the laboratory results for CK-MB and cardiac troponin in the following
conditions: muscular dystrophy, polymyositis, and extreme physical activity> - Answers -
CK-MB elevated, troponin normal
Organize the following events of the acute coronary syndromes in the correct order:
1) myocardial infarction
2) angina
3) unstable angina, frequently associated with minor myocardial infarction damage
4) extensive tissue necrosis
5) reversible tissue injury - Answers - 2, 5, 3, 1, 4
Which one of the following specimen types and collection methods is best for lab
assessment of brain natriuretic peptide (BNP) in the evaluation of congestive heart
failure? - Answers - EDTA-anticoagulated whole blood or plasma in plastic blood
collection tubes only
Which of the following represents in the correct sequence for the rise and fall of
myoglobin, CK-MB, and cTnI after an AMI? - Answers - Myoglobin, CK-MB, cTnI
Which of the following is a cause of hyperhomocyteinemia? - Answers - Deficiency of
one of the B complex vitamins (folate in particular)
Why would high-sensitivity C-reactive protein (CRP) be an indicator of a potential
myocardial infarction? - Answers - It is an acute phase reactant plasma protein that
rises in response to inflammation and the atherosclerotic process
The first myocardial marker to elevate following the onset of MI symptoms is
_______________. The concern with this marker is ______________. - Answers -
Myoglobin; this marker is considered nonspecific
The troponin complex is a set of three that participate in the regulation of muscle
contraction. Troponin ______ functions as the tropomyosin-binding component, troponin
______ functions as the inhibitory component, and the troponin ______ functions as the
calcium-binding component. - Answers - T; I; C
In a point of care (POC) test for a cardiac biomarker used in the evaluation of an
individual with possible acute coronary syndrome, which one of the following is a Lab
Medicine Practice guideline of the National Academy of Clinical Biochemistry (NACB)? -
Answers - POC assays should provide quantitive result
, Of the drugs used to treat cardiac muscle disease, which of the following requires the
closest lab monitoring of drug concentration in the body? - Answers - digoxin
In which of the following situations would cTnI be elevated? - Answers - Myocardial
infarction
The protein in cardiac muscle fibers that regulates contraction is? - Answers - Troponin
Which of the following lab tests would be the most useful in assisting the physician in
differentiating congestive heart failure from other conditions that have similar clinical
presentations? - Answers - BNP
Troponin remains elevated in the blood for how long after a myocardial infarction? -
Answers - 4 to 10 days
The energy for muscle contraction is generated by the hydrolysis of ATP by myosin.
The amount of ATP hydrolyzed during muscle contraction depends on what factors? -
Answers - the duration of contraction & the amount of work done by the muscle
Cardiac muscles uses a series of enzymes to maintain a high energy reserve. The
enzyme ________ functions to regenerate ATP by combing a phosphate group from an
energy-reserve molecules with ADP. The enzyme ________ also ensures adequate
ATP levels by combining two ADP molecules into ATP and AMP. The enzyme
________ functions to prevent accumulation of AMP in the muscle. - Answers - CK; MK;
AD
The atherogenic effect of homocysteine is ____________. - Answers - The toxic effect
of homocysteine on the endothelial lining of the arteries, which causes plaque formation
In which of the following disorders is measurement of brain type natriuretic peptide
(BNP) clinically useful? - Answers - Congestive heart failure
Which of the following statements is TRUE about cTnI? - Answers - Cardiac forms are
never expressed in skeletal muscle
Infusion of Nesiritide is documented to act as a confounder for which of the following
assays? - Answers - Brain natriuretic peptide
Which one of the following is considered to be the most specific marker for adverse
ventricular remodeling following an acute myocardial infarction? - Answers - Brain
natriuretic peptide (BNP)
The presence of heterophile antibodies, rheumatoid factor, increased blood levels of
hemoglobin and circulating cTnI autoantibodies result in which of the following? -
Answers - False positive and/or false negative result for cTnI assays
ANSWERS
What are the laboratory results for CK-MB and cardiac troponin in the following
conditions: muscular dystrophy, polymyositis, and extreme physical activity> - Answers -
CK-MB elevated, troponin normal
Organize the following events of the acute coronary syndromes in the correct order:
1) myocardial infarction
2) angina
3) unstable angina, frequently associated with minor myocardial infarction damage
4) extensive tissue necrosis
5) reversible tissue injury - Answers - 2, 5, 3, 1, 4
Which one of the following specimen types and collection methods is best for lab
assessment of brain natriuretic peptide (BNP) in the evaluation of congestive heart
failure? - Answers - EDTA-anticoagulated whole blood or plasma in plastic blood
collection tubes only
Which of the following represents in the correct sequence for the rise and fall of
myoglobin, CK-MB, and cTnI after an AMI? - Answers - Myoglobin, CK-MB, cTnI
Which of the following is a cause of hyperhomocyteinemia? - Answers - Deficiency of
one of the B complex vitamins (folate in particular)
Why would high-sensitivity C-reactive protein (CRP) be an indicator of a potential
myocardial infarction? - Answers - It is an acute phase reactant plasma protein that
rises in response to inflammation and the atherosclerotic process
The first myocardial marker to elevate following the onset of MI symptoms is
_______________. The concern with this marker is ______________. - Answers -
Myoglobin; this marker is considered nonspecific
The troponin complex is a set of three that participate in the regulation of muscle
contraction. Troponin ______ functions as the tropomyosin-binding component, troponin
______ functions as the inhibitory component, and the troponin ______ functions as the
calcium-binding component. - Answers - T; I; C
In a point of care (POC) test for a cardiac biomarker used in the evaluation of an
individual with possible acute coronary syndrome, which one of the following is a Lab
Medicine Practice guideline of the National Academy of Clinical Biochemistry (NACB)? -
Answers - POC assays should provide quantitive result
, Of the drugs used to treat cardiac muscle disease, which of the following requires the
closest lab monitoring of drug concentration in the body? - Answers - digoxin
In which of the following situations would cTnI be elevated? - Answers - Myocardial
infarction
The protein in cardiac muscle fibers that regulates contraction is? - Answers - Troponin
Which of the following lab tests would be the most useful in assisting the physician in
differentiating congestive heart failure from other conditions that have similar clinical
presentations? - Answers - BNP
Troponin remains elevated in the blood for how long after a myocardial infarction? -
Answers - 4 to 10 days
The energy for muscle contraction is generated by the hydrolysis of ATP by myosin.
The amount of ATP hydrolyzed during muscle contraction depends on what factors? -
Answers - the duration of contraction & the amount of work done by the muscle
Cardiac muscles uses a series of enzymes to maintain a high energy reserve. The
enzyme ________ functions to regenerate ATP by combing a phosphate group from an
energy-reserve molecules with ADP. The enzyme ________ also ensures adequate
ATP levels by combining two ADP molecules into ATP and AMP. The enzyme
________ functions to prevent accumulation of AMP in the muscle. - Answers - CK; MK;
AD
The atherogenic effect of homocysteine is ____________. - Answers - The toxic effect
of homocysteine on the endothelial lining of the arteries, which causes plaque formation
In which of the following disorders is measurement of brain type natriuretic peptide
(BNP) clinically useful? - Answers - Congestive heart failure
Which of the following statements is TRUE about cTnI? - Answers - Cardiac forms are
never expressed in skeletal muscle
Infusion of Nesiritide is documented to act as a confounder for which of the following
assays? - Answers - Brain natriuretic peptide
Which one of the following is considered to be the most specific marker for adverse
ventricular remodeling following an acute myocardial infarction? - Answers - Brain
natriuretic peptide (BNP)
The presence of heterophile antibodies, rheumatoid factor, increased blood levels of
hemoglobin and circulating cTnI autoantibodies result in which of the following? -
Answers - False positive and/or false negative result for cTnI assays
