NU641 Final Exam Test Bank 2 Latest
with 600 Questions and Correct Verified
Answers/ Regis NU641 Final Exam
Preparation Test Bank/ NU 641
SECTION 1: NEUROLOGIC PHARMACOLOGY (Questions 1-
60)
Parkinson's Disease & Movement Disorders
1. Classification of drug therapy for Parkinson's disease includes which of the
following categories?
A) Dopaminergic agents, anticholinergic agents, and amantadine
B) Beta-blockers and calcium channel blockers
C) ACE inhibitors and ARBs
D) SSRIs and MAOIs
Answer: A
Rationale: Parkinson's disease treatment includes dopaminergic agents (promote
dopamine receptor activation), anticholinergic agents (prevent cholinergic receptor
activation), and amantadine. Exercise is also a natural way to increase dopamine .
2. Dopaminergic agents for Parkinson's disease work through which mechanism?
,A) Promotion of dopamine synthesis and prevention of dopamine breakdown
B) Blocking acetylcholine receptors
C) Increasing serotonin levels
D) Inhibiting GABA receptors
Answer: A
Rationale: Dopaminergic agents promote dopamine synthesis and prevent its
breakdown, increasing dopamine availability in the brain. Levodopa is the most effective
dopaminergic agent .
3. Benztropine (Cogentin) is classified as which type of drug for Parkinson's
disease?
A) Dopaminergic agent
B) Anticholinergic agent
C) MAO-B inhibitor
D) COMT inhibitor
Answer: B
Rationale: Benztropine is an anticholinergic agent that prevents activation of
cholinergic receptors, helping to balance dopamine and acetylcholine levels in
Parkinson's disease .
4. A patient on carbidopa-levodopa develops dyskinesias. What is the appropriate
management?
A) Increase the dose
B) Decrease the dose or adjust the dosing schedule
C) Add an anticholinergic
D) Discontinue levodopa
Answer: B
,Rationale: Dyskinesias are dose-related complications of levodopa therapy. Adjusting
the dose or dosing schedule (more frequent smaller doses) helps manage dyskinesias
while maintaining symptom control.
5. Which anticholinergic agent is used to control tremors and relax smooth
muscles in Parkinson's disease?
A) Levodopa
B) Cholinergic blockers
C) Amantadine
D) Selegiline
Answer: B
Rationale: Cholinergic blockers (anticholinergics) are used to control tremors and relax
smooth muscles in Parkinson's disease. They also inhibit the muscarinic action of
acetylcholine on bladder muscle .
Alzheimer's Disease & Dementia
6. Donepezil is used to treat Alzheimer's disease. Its mechanism of action is:
A) Inhibiting acetylcholinesterase
B) Blocking NMDA receptors
C) Increasing dopamine
D) Reducing amyloid plaques
Answer: A
Rationale: Donepezil is a cholinesterase inhibitor that increases acetylcholine availability
by preventing its breakdown, improving cognitive function in mild-to-moderate
Alzheimer's disease.
, 7. Memantine is used to treat Alzheimer's disease and is NOT an anticholinergic.
Its mechanism of action is:
A) Inhibiting acetylcholinesterase
B) Blocking NMDA receptors
C) Increasing serotonin
D) Reducing inflammation
Answer: B
Rationale: Memantine is an NMDA receptor antagonist that protects neurons from
excitotoxicity (excessive glutamate). It is used in moderate-to-severe Alzheimer's disease
and is not an anticholinergic .
Epilepsy & Anticonvulsants
8. Although a patient sees a neurologist for management of partial seizures, why is
it important to know their medication regimen?
A) To ensure proper dosing
B) There are many drug-drug interactions with anticonvulsants
C) To monitor for seizures
D) To check compliance
Answer: B
Rationale: Anticonvulsants (especially phenytoin, carbamazepine, valproate) have
significant drug-drug interactions through CYP450 induction or inhibition.
Polypharmacy requires careful monitoring .
9. Routine education for a patient being treated with levetiracetam (Keppra) for
seizures includes:
A) Take with grapefruit juice
B) Do not abruptly discontinue due to risk of withdrawal seizures
with 600 Questions and Correct Verified
Answers/ Regis NU641 Final Exam
Preparation Test Bank/ NU 641
SECTION 1: NEUROLOGIC PHARMACOLOGY (Questions 1-
60)
Parkinson's Disease & Movement Disorders
1. Classification of drug therapy for Parkinson's disease includes which of the
following categories?
A) Dopaminergic agents, anticholinergic agents, and amantadine
B) Beta-blockers and calcium channel blockers
C) ACE inhibitors and ARBs
D) SSRIs and MAOIs
Answer: A
Rationale: Parkinson's disease treatment includes dopaminergic agents (promote
dopamine receptor activation), anticholinergic agents (prevent cholinergic receptor
activation), and amantadine. Exercise is also a natural way to increase dopamine .
2. Dopaminergic agents for Parkinson's disease work through which mechanism?
,A) Promotion of dopamine synthesis and prevention of dopamine breakdown
B) Blocking acetylcholine receptors
C) Increasing serotonin levels
D) Inhibiting GABA receptors
Answer: A
Rationale: Dopaminergic agents promote dopamine synthesis and prevent its
breakdown, increasing dopamine availability in the brain. Levodopa is the most effective
dopaminergic agent .
3. Benztropine (Cogentin) is classified as which type of drug for Parkinson's
disease?
A) Dopaminergic agent
B) Anticholinergic agent
C) MAO-B inhibitor
D) COMT inhibitor
Answer: B
Rationale: Benztropine is an anticholinergic agent that prevents activation of
cholinergic receptors, helping to balance dopamine and acetylcholine levels in
Parkinson's disease .
4. A patient on carbidopa-levodopa develops dyskinesias. What is the appropriate
management?
A) Increase the dose
B) Decrease the dose or adjust the dosing schedule
C) Add an anticholinergic
D) Discontinue levodopa
Answer: B
,Rationale: Dyskinesias are dose-related complications of levodopa therapy. Adjusting
the dose or dosing schedule (more frequent smaller doses) helps manage dyskinesias
while maintaining symptom control.
5. Which anticholinergic agent is used to control tremors and relax smooth
muscles in Parkinson's disease?
A) Levodopa
B) Cholinergic blockers
C) Amantadine
D) Selegiline
Answer: B
Rationale: Cholinergic blockers (anticholinergics) are used to control tremors and relax
smooth muscles in Parkinson's disease. They also inhibit the muscarinic action of
acetylcholine on bladder muscle .
Alzheimer's Disease & Dementia
6. Donepezil is used to treat Alzheimer's disease. Its mechanism of action is:
A) Inhibiting acetylcholinesterase
B) Blocking NMDA receptors
C) Increasing dopamine
D) Reducing amyloid plaques
Answer: A
Rationale: Donepezil is a cholinesterase inhibitor that increases acetylcholine availability
by preventing its breakdown, improving cognitive function in mild-to-moderate
Alzheimer's disease.
, 7. Memantine is used to treat Alzheimer's disease and is NOT an anticholinergic.
Its mechanism of action is:
A) Inhibiting acetylcholinesterase
B) Blocking NMDA receptors
C) Increasing serotonin
D) Reducing inflammation
Answer: B
Rationale: Memantine is an NMDA receptor antagonist that protects neurons from
excitotoxicity (excessive glutamate). It is used in moderate-to-severe Alzheimer's disease
and is not an anticholinergic .
Epilepsy & Anticonvulsants
8. Although a patient sees a neurologist for management of partial seizures, why is
it important to know their medication regimen?
A) To ensure proper dosing
B) There are many drug-drug interactions with anticonvulsants
C) To monitor for seizures
D) To check compliance
Answer: B
Rationale: Anticonvulsants (especially phenytoin, carbamazepine, valproate) have
significant drug-drug interactions through CYP450 induction or inhibition.
Polypharmacy requires careful monitoring .
9. Routine education for a patient being treated with levetiracetam (Keppra) for
seizures includes:
A) Take with grapefruit juice
B) Do not abruptly discontinue due to risk of withdrawal seizures
