ORIGINAL EXAM MASTERY
100 Original Practice Questions • Detailed Answers & Rationales • 2026 Edition
Designed as an independent study resource for Adult-Gerontology Primary Care Nurse
Practitioner preparation. The questions are newly authored and are not reproduced from the
referenced Stuvia document, an AANPCB/NPCB examination, or any proprietary test bank.
Resource format 100 multiple-choice questions + answers + rationales
Clinical emphasis Adolescent through older adult primary care
Question style Assessment → diagnosis → planning → evaluation / clinical judgment
Major domains Cardiology, pulmonary, endocrine, GI, renal/GU, neuro, MSK, ID, derm, geriatrics, women's/men's health, pharma
Use Active recall, timed practice, remediation, and final rapid review
Important: This guide is for educational preparation only. Clinical decisions should follow current guidelines, local standards, patient-specific
factors, and credentialing requirements where applicable.
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,How to Use This Guide
The current NPCB/AANPCB AGNP certification page describes a 150-question competency-based examination,
with 135 scored items. The scored blueprint is organized around Assess, Diagnose, Plan, and Evaluate, and the
exam covers adolescent through older-adult populations. The official knowledge areas include health
assessment, pathophysiology, therapeutics, evidence-informed practice, prevention, social determinants of
health, transitions of care, diverse populations, legal/ethical issues, and interprofessional practice.
Recommended method: Complete questions without looking at the answers, mark uncertain items, then review
the rationale. For every missed question, write (1) the clue you missed, (2) the dangerous alternative diagnosis,
and (3) the next-best action.
High-Yield Exam Traps
Trap Better approach
Jumping to the diagnosis Identify instability and the highest-risk diagnosis first.
Treating a screening test as diagnosticKnow when confirmatory testing is required.
Ignoring age-related changes Consider frailty, renal function, polypharmacy, cognition, and functional status.
Choosing the most detailed answer Choose the safest evidence-based next step, not the most elaborate intervention.
Missing red flags Prioritize sudden neurologic deficits, shock, severe bleeding, airway compromise, sepsis, and acute abdomen
Overtreating Use antimicrobial, imaging, and medication stewardship.
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, Cardiology
Question 1. A 72-year-old with hypertension has an office BP of 168/82 mmHg on three visits. Which finding
best explains why this pattern is common with aging?
A. Increased arterial stiffness
B. Increased plasma volume only
C. Reduced systemic vascular resistance
D. Increased vagal tone
Answer: A
Rationale: Age-related loss of arterial elasticity increases pulse pressure and commonly produces isolated systolic
hypertension.
Question 2. A patient with atrial fibrillation is taking warfarin. Which INR range is generally targeted for stroke
prevention in nonvalvular atrial fibrillation?
A. 0.8–1.2
B. 1.2–1.8
C. 2.0–3.0
D. 3.5–5.0
Answer: C
Rationale: For most patients with nonvalvular atrial fibrillation treated with warfarin, the therapeutic INR target is 2.0–3.0.
Question 3. A 68-year-old with exertional chest pressure has a normal resting ECG. Which symptom pattern
most strongly supports stable angina?
A. Predictable discomfort with exertion relieved by rest
B. Pain lasting seconds with movement
C. Pain reproducible by palpation only
D. Pain occurring exclusively after meals
Answer: A
Rationale: Stable angina is classically predictable with exertion or stress and improves with rest or antianginal therapy.
Question 4. A patient taking an ACE inhibitor develops facial swelling and tongue enlargement. What is the
priority?
A. Continue the medication and recheck in one week
B. Treat as possible angioedema and address the airway urgently
C. Add an antihistamine and send home
D. Switch immediately to another ACE inhibitor
Answer: B
Rationale: ACE-inhibitor angioedema can threaten the airway. The medication should be stopped and urgent airway
assessment performed.
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