Question 1
A laboratory result indicates that the peak level for a drug is above the minimum toxic
concentration. This means that the:
A:Concentration will produce an adverse response
B: Time between doses must be shortened
C: Concentration will produce therapeutic effects
D: Duration of action of drug is too long
CORRECT ANSWER
A
Question 2
Which of the following substances is most likely to be absorbed in the intestines rather
than in the stomach?
A:ETOH
B: Enteric coated medications
C: Acidic products
D: Long acting agents
CORRECT ANSWER
Sodium Bicarbonate
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,Question 3
Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
A: Decreased therapeutic levels of quinidine
B: Increased therapeutic levels of quinidine
C: Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein
for absorption and elimination
D: Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein
for absorption and elimination
CORRECT ANSWER
C
Question 4
Therapeutic drug levels are drawn when a drug reaches a steady state. Drugs reach steady
state:
A: One hour after IV administration
B: When patient feels full effect of drug
C: After second dose
D: After four to five half lives
CORRECT ANSWER
D
Question 5
Which of the following about bioavailability is true?
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,A: Especially important for drugs with narrow therapeutic ranges or sustained release
metabolism
B: Drugs that are administered more than once a day have a greater bioavailability than
those given once per day
C: All brands of drugs have the same bioavailability
D: Combining an active drug with an inherent substance does not affect bioavailability
CORRECT ANSWER
A
Question 6
A major disadvantage to IV administration is that:
A: Absorption of the drug cannot be slowed after administration
B: First pass metabolism is eliminated
C: It is significantly more expensive than other routes
D: Needles and sterility re required
CORRECT ANSWER
C
Question 7
All drugs continue to act in the body until they are changed or excreted. The ability of the
body to excrete drugs via the renal system would be increased by:
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease
3. Competition for a transport site by another drug
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, 4. Increased renal blood flow
CORRECT ANSWER
D
Question 8
Cost-effectiveness analysis compares two or more treatments or programs that are:
A: Considered equal in efficacy
B: Not necessarily therapeutically equivalent
C: Expressed in terms of patient preference or quality adjusted life years
D: Compared with the other dollar value of the benefit received
CORRECT ANSWER
B
Question 9
The elderly are at high risk of ADRs due to:
A: Having greater muscle mass than younger adults, leading to higher volume of distribution
B: The extensive studies that have been conducted on drug safety in this age group
C: The blood-brain barrier being less permeable, requiring higher doses to achieve
therapeutic effect
D: Age-related decrease in renal function
CORRECT ANSWER
D
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A laboratory result indicates that the peak level for a drug is above the minimum toxic
concentration. This means that the:
A:Concentration will produce an adverse response
B: Time between doses must be shortened
C: Concentration will produce therapeutic effects
D: Duration of action of drug is too long
CORRECT ANSWER
A
Question 2
Which of the following substances is most likely to be absorbed in the intestines rather
than in the stomach?
A:ETOH
B: Enteric coated medications
C: Acidic products
D: Long acting agents
CORRECT ANSWER
Sodium Bicarbonate
1
@THE STUDY VAULT
,Question 3
Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
A: Decreased therapeutic levels of quinidine
B: Increased therapeutic levels of quinidine
C: Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein
for absorption and elimination
D: Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein
for absorption and elimination
CORRECT ANSWER
C
Question 4
Therapeutic drug levels are drawn when a drug reaches a steady state. Drugs reach steady
state:
A: One hour after IV administration
B: When patient feels full effect of drug
C: After second dose
D: After four to five half lives
CORRECT ANSWER
D
Question 5
Which of the following about bioavailability is true?
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,A: Especially important for drugs with narrow therapeutic ranges or sustained release
metabolism
B: Drugs that are administered more than once a day have a greater bioavailability than
those given once per day
C: All brands of drugs have the same bioavailability
D: Combining an active drug with an inherent substance does not affect bioavailability
CORRECT ANSWER
A
Question 6
A major disadvantage to IV administration is that:
A: Absorption of the drug cannot be slowed after administration
B: First pass metabolism is eliminated
C: It is significantly more expensive than other routes
D: Needles and sterility re required
CORRECT ANSWER
C
Question 7
All drugs continue to act in the body until they are changed or excreted. The ability of the
body to excrete drugs via the renal system would be increased by:
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease
3. Competition for a transport site by another drug
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, 4. Increased renal blood flow
CORRECT ANSWER
D
Question 8
Cost-effectiveness analysis compares two or more treatments or programs that are:
A: Considered equal in efficacy
B: Not necessarily therapeutically equivalent
C: Expressed in terms of patient preference or quality adjusted life years
D: Compared with the other dollar value of the benefit received
CORRECT ANSWER
B
Question 9
The elderly are at high risk of ADRs due to:
A: Having greater muscle mass than younger adults, leading to higher volume of distribution
B: The extensive studies that have been conducted on drug safety in this age group
C: The blood-brain barrier being less permeable, requiring higher doses to achieve
therapeutic effect
D: Age-related decrease in renal function
CORRECT ANSWER
D
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