ATI RN PHARMACOLOGY
COMPREHENSIVE PRACTICE EXAM ALL
QUESTIONS AND CORRECT DETAILED
ANSWERS ALREADY A GRADED WITH
EXPERT FEEDBACK |CURRENTLY TESTING |
NEW AND REVISED
2026–2027 EDITION
350 Original Practice Questions • Answers • Clinical Rationales
FORMAT
Four-option multiple choice
Correct answer highlighted in yellow
Clinical rationale after every question
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 1
, Medication-safety and clinical-application focus
TABLE OF CONTENTS
Section 1 — Cardiovascular & Hematologic Pharmacology
Questions 1–50
Section 2 — Respiratory & Allergy Pharmacology
Questions 51–100
Section 3 — Pain, Anti-Inflammatory & Neurologic Pharmacology
Questions 101–150
Section 4 — Anti-Infective Pharmacology
Questions 151–200
Section 5 — Endocrine, Diabetes & Metabolic Pharmacology
Questions 201–250
Section 6 — Psychiatric, GI & Common Medication Safety
Questions 251–300
Section 7 — Emergency Medications, Reversal Agents & Advanced Safety Review
Questions 301–350
Study format: Every item presents four options, followed by a highlighted answer and concise clinical rationale.
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 2
, 1. A nurse is reviewing the medication lisinopril. Which is the primary therapeutic purpose of this medication?
A. To provide general anesthesia for every procedure
B. Hypertension
C. To replace all missing electrolytes regardless of the laboratory value
D. To treat every type of acute allergic reaction
ANSWER — B. Hypertension
Rationale: The medication is used for hypertension. The nurse should connect the drug's indication with its expected therapeutic effect.
2. A client is receiving lisinopril. Which finding should the nurse recognize as an important adverse effect or
safety concern?
A. Permanent improvement in hearing in all clients
B. Severe hypercalcemia as an expected therapeutic response
C. Markedly increased appetite as the primary expected effect
D. Persistent dry cough
ANSWER — D. Persistent dry cough
Rationale: Persistent dry cough is an important adverse effect or safety concern associated with this medication and should be monitored
or reported as appropriate.
3. Which assessment or laboratory monitoring is most appropriate for a client taking lisinopril?
A. Visual acuity only, regardless of the medication
B. Blood pressure, potassium, and renal function
C. Daily hearing tests for every client
D. Serum calcium only, regardless of the medication
ANSWER — B. Blood pressure, potassium, and renal function
Rationale: Monitoring blood pressure, potassium, and renal function helps the nurse evaluate therapeutic response and detect
medication-related complications.
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 3
, 4. Which client statement indicates correct understanding of teaching about lisinopril?
A. Double the next dose whenever one dose is missed
B. Rise slowly and report facial/lip swelling
C. Take the medication with alcohol to improve absorption
D. Stop the medication whenever symptoms improve without consulting the prescriber
ANSWER — B. Rise slowly and report facial/lip swelling
Rationale: Correct teaching includes: rise slowly and report facial/lip swelling. This reduces preventable adverse effects and supports
safe medication use.
5. A client taking lisinopril develops a concerning medication-related finding. What is the nurse's priority
response?
A. Stop the medication and seek emergency care for angioedema
B. Continue the medication and ignore the finding
C. Document the finding only and provide no further action
D. Give an additional dose immediately without reassessment
ANSWER — A. Stop the medication and seek emergency care for angioedema
Rationale: The priority is to respond to the safety concern: stop the medication and seek emergency care for angioedema. Further
treatment and monitoring should follow the prescribed clinical or emergency protocol.
6. A nurse is reviewing the medication losartan. Which is the primary therapeutic purpose of this medication?
A. To provide general anesthesia for every procedure
B. To replace all missing electrolytes regardless of the laboratory value
C. To treat every type of acute allergic reaction
D. Hypertension
ANSWER — D. Hypertension
Rationale: The medication is used for hypertension. The nurse should connect the drug's indication with its expected therapeutic effect.
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 4
COMPREHENSIVE PRACTICE EXAM ALL
QUESTIONS AND CORRECT DETAILED
ANSWERS ALREADY A GRADED WITH
EXPERT FEEDBACK |CURRENTLY TESTING |
NEW AND REVISED
2026–2027 EDITION
350 Original Practice Questions • Answers • Clinical Rationales
FORMAT
Four-option multiple choice
Correct answer highlighted in yellow
Clinical rationale after every question
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 1
, Medication-safety and clinical-application focus
TABLE OF CONTENTS
Section 1 — Cardiovascular & Hematologic Pharmacology
Questions 1–50
Section 2 — Respiratory & Allergy Pharmacology
Questions 51–100
Section 3 — Pain, Anti-Inflammatory & Neurologic Pharmacology
Questions 101–150
Section 4 — Anti-Infective Pharmacology
Questions 151–200
Section 5 — Endocrine, Diabetes & Metabolic Pharmacology
Questions 201–250
Section 6 — Psychiatric, GI & Common Medication Safety
Questions 251–300
Section 7 — Emergency Medications, Reversal Agents & Advanced Safety Review
Questions 301–350
Study format: Every item presents four options, followed by a highlighted answer and concise clinical rationale.
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 2
, 1. A nurse is reviewing the medication lisinopril. Which is the primary therapeutic purpose of this medication?
A. To provide general anesthesia for every procedure
B. Hypertension
C. To replace all missing electrolytes regardless of the laboratory value
D. To treat every type of acute allergic reaction
ANSWER — B. Hypertension
Rationale: The medication is used for hypertension. The nurse should connect the drug's indication with its expected therapeutic effect.
2. A client is receiving lisinopril. Which finding should the nurse recognize as an important adverse effect or
safety concern?
A. Permanent improvement in hearing in all clients
B. Severe hypercalcemia as an expected therapeutic response
C. Markedly increased appetite as the primary expected effect
D. Persistent dry cough
ANSWER — D. Persistent dry cough
Rationale: Persistent dry cough is an important adverse effect or safety concern associated with this medication and should be monitored
or reported as appropriate.
3. Which assessment or laboratory monitoring is most appropriate for a client taking lisinopril?
A. Visual acuity only, regardless of the medication
B. Blood pressure, potassium, and renal function
C. Daily hearing tests for every client
D. Serum calcium only, regardless of the medication
ANSWER — B. Blood pressure, potassium, and renal function
Rationale: Monitoring blood pressure, potassium, and renal function helps the nurse evaluate therapeutic response and detect
medication-related complications.
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 3
, 4. Which client statement indicates correct understanding of teaching about lisinopril?
A. Double the next dose whenever one dose is missed
B. Rise slowly and report facial/lip swelling
C. Take the medication with alcohol to improve absorption
D. Stop the medication whenever symptoms improve without consulting the prescriber
ANSWER — B. Rise slowly and report facial/lip swelling
Rationale: Correct teaching includes: rise slowly and report facial/lip swelling. This reduces preventable adverse effects and supports
safe medication use.
5. A client taking lisinopril develops a concerning medication-related finding. What is the nurse's priority
response?
A. Stop the medication and seek emergency care for angioedema
B. Continue the medication and ignore the finding
C. Document the finding only and provide no further action
D. Give an additional dose immediately without reassessment
ANSWER — A. Stop the medication and seek emergency care for angioedema
Rationale: The priority is to respond to the safety concern: stop the medication and seek emergency care for angioedema. Further
treatment and monitoring should follow the prescribed clinical or emergency protocol.
6. A nurse is reviewing the medication losartan. Which is the primary therapeutic purpose of this medication?
A. To provide general anesthesia for every procedure
B. To replace all missing electrolytes regardless of the laboratory value
C. To treat every type of acute allergic reaction
D. Hypertension
ANSWER — D. Hypertension
Rationale: The medication is used for hypertension. The nurse should connect the drug's indication with its expected therapeutic effect.
RN Pharmacology • 350 Original Practice Questions • 2026–2027 Page 4
