IH: FINAL QUESTIONS - HLA, HPC, QM UPDATED ACTUAL QUESTIONS AND CORRECT ANSWERS

IH: FINAL QUESTIONS - HLA, HPC, QM UPDATED
ACTUAL QUESTIONS AND CORRECT ANSWERS

Question:
1. The HLA genes are located on which chromosome?
a. 2
b. 4
c. 6
d. 8
Answer:
c. 6

Question:
2. The majority of HLA antibodies belongs to what immunoglobulin class?
a. IgD
b. IgE
c. IgG
d. IgM
Answer:
c. IgG

Question:
3. What is the test of choice for HLA antigen testing?
a. Agglutination
b. Molecular
c. Cytotoxicity
d. ELISA
Answer:
b. Molecular

Question:
4. Of the following diseases, which one has the highest relative risk in association with an HLA antigen?
a. Ankylosing spondylitis
b. Juvenile diabetes
c. Narcolepsy
d. Rheumatoid arthritis
Answer:
a. Ankylosing spondylitis

Question:
5. Why is HLA matching not feasible in cardiac transplantation?
a. No HLAs are present on cardiac cells
b. No donors ever have HLA antibodies
c. Total ischemic time is too long
d. Total ischemic time is too short

, Answer:
d. Total ischemic time is too short

Question:
6. DR52 molecules are the product of which alleles?
a. DRA and DRB1
b. DRA and DRB3
c. DRA and DRB4
d. DRA and DRB5
Answer:
b. DRA and DRB3

Question:
7. What is the molecular technique that detects undefined alleles?
a. Restriction fragment length polymorphism
b. Sequence-specific primer typing
c. Sequence-specific oligonucleotide typing
d. Direct nucleotide sequencing
Answer:
d. Direct nucleotide sequencing

Question:
8. What represents the association of the alleles on the two C6 chromosomes as determined by family
studies?
a. Haplotype
b. Genotype
c. Phenotype
d. Xenotype
Answer:
a. Haplotype

Question:
9. The HLA class I region encodes genes for the classic transplantation molecules
Answer:
HLA-A, HLA-B, and HLA-C

Question:
10. The HLA class II region encodes genes for the molecules
Answer:
HLA-DR, HLA-DP, and HLA-DQ

Question:
11. The HLA class III region encodes genes for
Answer:
C2, C4, Bf (complement factors), 21-hydroxylase, and tumor necrosis factor.