BIOM 3090 MIDTERM (UNITS 1-3) UPDATED ACTUAL
QUESTIONS AND CORRECT ANSWERS
Question:
1. Pharmacokinetics
Answer:
describes how the body affects a specific drug
Question:
2. Bioavailability
Answer:
the amount of an administered dose of drug that reaches systemic circulation
Bioavailability = quantity of drug reaching systemic circulation / quantity of drug
administered
Question:
3. pKa
Answer:
the ionization constant for acids and bases and is equal to the pH at which 50% of
the drug is ionized
Question:
4. Henderson-Hasselbalch Equation
Answer:
pKa - pH = log (protonated/unprotonated)
Question:
5. Which side of the membrane do drugs accumulate?
Answer:
The side where ionization is highest
Question:
6. Which fluids do basic drugs accumulate in?
Answer:
Acidic fluids
Question:
7. Which fluids do acidic drugs accumulate in?
Answer:
Basic fluids
, Question:
8. What is the simplest drug route?
Answer:
Oral
Question:
9. What are the advantages of oral administration?
Answer:
- simple & convenient
- safer than injections
- painless
Question:
10. What are the disadvantages of oral administration
Answer:
- absorption may be erratic
- patient compliance issues
- slow delivery
- first pass effect
Question:
11. What is the first pass effect?
Answer:
When liver enzymes inactive a portion of the ingested drug and the dosage may
be altered
Question:
12. What are the 6 parenteral drug routes?
Answer:
1. Subcutaneous injection (SC)
2. Intramuscular injection (IM)
3. Intravenous injection (IV)
4. Sublingual
5. Topical
6. Transdermal
Question:
13. What are the advantages of SC administration?
Answer:
- Easier than IV
- Absorption is slower than IV or IM
- Suitable for solid pellets, insoluble suspensions
QUESTIONS AND CORRECT ANSWERS
Question:
1. Pharmacokinetics
Answer:
describes how the body affects a specific drug
Question:
2. Bioavailability
Answer:
the amount of an administered dose of drug that reaches systemic circulation
Bioavailability = quantity of drug reaching systemic circulation / quantity of drug
administered
Question:
3. pKa
Answer:
the ionization constant for acids and bases and is equal to the pH at which 50% of
the drug is ionized
Question:
4. Henderson-Hasselbalch Equation
Answer:
pKa - pH = log (protonated/unprotonated)
Question:
5. Which side of the membrane do drugs accumulate?
Answer:
The side where ionization is highest
Question:
6. Which fluids do basic drugs accumulate in?
Answer:
Acidic fluids
Question:
7. Which fluids do acidic drugs accumulate in?
Answer:
Basic fluids
, Question:
8. What is the simplest drug route?
Answer:
Oral
Question:
9. What are the advantages of oral administration?
Answer:
- simple & convenient
- safer than injections
- painless
Question:
10. What are the disadvantages of oral administration
Answer:
- absorption may be erratic
- patient compliance issues
- slow delivery
- first pass effect
Question:
11. What is the first pass effect?
Answer:
When liver enzymes inactive a portion of the ingested drug and the dosage may
be altered
Question:
12. What are the 6 parenteral drug routes?
Answer:
1. Subcutaneous injection (SC)
2. Intramuscular injection (IM)
3. Intravenous injection (IV)
4. Sublingual
5. Topical
6. Transdermal
Question:
13. What are the advantages of SC administration?
Answer:
- Easier than IV
- Absorption is slower than IV or IM
- Suitable for solid pellets, insoluble suspensions
