BLD 204 UPDATED ACTUAL QUESTIONS AND
CORRECT ANSWERS
Question:
1. humoral immunity
Answer:
B cells and helper T cells (CD4+) to provide immunity by producing antibodies.
They recognize antigen free from MHC. Primary humoral responses are slower
than Primary cellular responses.
Question:
2. cellular immunity
Answer:
T cells that directly destroy cells with antigen. However, antigen must be
presented to T cells by MHC molecules. Faster primary response than humoral
responses.
Question:
3. antigen
Answer:
"non self" molecules. They are capable of inflicting an immune response. Only the
epitope is recognized. Antigens can be either exogenous or endogenous
Question:
4. Antibodies (immunoglobulins)
Answer:
attack foreign proteins and pathogens. one unit is 2 identical heavy chains and
two identical light chains that come together to ford 2 antigen binding sites.
"GAMED"
Question:
5. function of dendritic cells as an APC in immune
responses
Answer:
capture and present antigens to T cells, express MHC class 2 and T cell
costimulatory molecules, found in T cell zones in lymphoid tissue
, Question:
6. function of macrophages as an APC in immune responses
Answer:
phagocytose and present antigen. phagocytosis occurs and then is chopped up
into bits and loaded into MHC class 2 molecules
Question:
7. B cells
Answer:
Recognize antigen with their BCR and present it.
1. recognize and present antigen
2. take ti in and process it
3. present via MHC class 2 molecules to helper Ts
Question:
8. MHC class 1 proteins
Answer:
presented on ALL nucleated cells (endogenous antigen). signal to CD4+ cytotoxic
Ts, heavy alpha chain and B2 microglobulin chain
Question:
9. MHC class 2 molecules
Answer:
presented on professional APCs, antigen is consumed processed and presented
in MHC 2 by these cells (exogenous). Two peptide chains of more equal size.
signal is recognized by CD44+ helper Ts
Question:
10. IgG
Answer:
70-80% of Igs in plasma. only cells that are able to cross the placenta. opsonizes
and neutralizes toxins. diffuses out of vasculature
Question:
11. IgM
Answer:
first Ig produced in an immune response. It is the largest Ig (pentamer). Has 10
binding sites which is good for repeating epitopes. Units are joined together at Fc
fragments by a J chain.
CORRECT ANSWERS
Question:
1. humoral immunity
Answer:
B cells and helper T cells (CD4+) to provide immunity by producing antibodies.
They recognize antigen free from MHC. Primary humoral responses are slower
than Primary cellular responses.
Question:
2. cellular immunity
Answer:
T cells that directly destroy cells with antigen. However, antigen must be
presented to T cells by MHC molecules. Faster primary response than humoral
responses.
Question:
3. antigen
Answer:
"non self" molecules. They are capable of inflicting an immune response. Only the
epitope is recognized. Antigens can be either exogenous or endogenous
Question:
4. Antibodies (immunoglobulins)
Answer:
attack foreign proteins and pathogens. one unit is 2 identical heavy chains and
two identical light chains that come together to ford 2 antigen binding sites.
"GAMED"
Question:
5. function of dendritic cells as an APC in immune
responses
Answer:
capture and present antigens to T cells, express MHC class 2 and T cell
costimulatory molecules, found in T cell zones in lymphoid tissue
, Question:
6. function of macrophages as an APC in immune responses
Answer:
phagocytose and present antigen. phagocytosis occurs and then is chopped up
into bits and loaded into MHC class 2 molecules
Question:
7. B cells
Answer:
Recognize antigen with their BCR and present it.
1. recognize and present antigen
2. take ti in and process it
3. present via MHC class 2 molecules to helper Ts
Question:
8. MHC class 1 proteins
Answer:
presented on ALL nucleated cells (endogenous antigen). signal to CD4+ cytotoxic
Ts, heavy alpha chain and B2 microglobulin chain
Question:
9. MHC class 2 molecules
Answer:
presented on professional APCs, antigen is consumed processed and presented
in MHC 2 by these cells (exogenous). Two peptide chains of more equal size.
signal is recognized by CD44+ helper Ts
Question:
10. IgG
Answer:
70-80% of Igs in plasma. only cells that are able to cross the placenta. opsonizes
and neutralizes toxins. diffuses out of vasculature
Question:
11. IgM
Answer:
first Ig produced in an immune response. It is the largest Ig (pentamer). Has 10
binding sites which is good for repeating epitopes. Units are joined together at Fc
fragments by a J chain.
