BLD 204 HEMOSTASIS & GENETICS UPDATED
ACTUAL QUESTIONS AND CORRECT ANSWERS
Question:
1. Major components of Hemostasis
Answer:
- vascular wall (endothelium)
- platelets (thrombocytes)
- coagulation cascade (circulation)
Question:
2. Petechiae
Answer:
Pinpoint bruising; blood vessels.
Question:
3. Purpura
Answer:
Multiple pinpoint bruises (appearing slightly larger than petechiae); accumulation
of blood under the skin
Question:
4. Ecchymoses
Answer:
Average bruise from a good hit.
Question:
5. Agents able to initiate clot formation
Answer:
Intrinsic - Negatively charged surface; glass beads, platelet aggregation
(example).
Extrinsic - Tissue factor.
Question:
6. Five steps of Hemostasis
Answer:
- Vasoconstriction
- Platelets; Adhesion, activation, aggregation.
- Coagulation cascade > Thrombin cuts fibrinogen.
- Thrombin > Stabilizes clot.
- Counter-regulation; degrades clot when no longer needed.
, Question:
7. Primary hemostasis
Answer:
Platelet plug - damage to endothelial layer, exposing ECM > facilitating AAA.
Question:
8. Secondary hemostasis
Answer:
Stable clot formation - thrombin cleaves fibrinogen, forming a fibrin clot OR
activates platelets and reinforces platelet plug.
Question:
9. Anticoagulant endothelium functions
Answer:
- Inhibit platelets by hiding ECM.
- Inhibits Coagulation factors w/ heparin like molecules, Thrombomodulin, and
TFPI.
- Fibrinolysis; TTPA.
Question:
10. Procoagulant endothelium functions
Answer:
- vWF activation of platelets.
- TF activation of coagulation cascade.
- Plasminogen activator inhibitors.
Question:
11. Platelet adhesion explained
Answer:
Mediated by vWF interactions (bridge b/w platelet surface receptor and Ib and
collagen.
Question:
12. Platelet activation explained
Answer:
Platelets change shape > granules release:
- Ca++ > Coagulation factors.
- ADP > Platelet activator.
- TxA2 > activates more platelets, aggregation (AA metabolism).
ACTUAL QUESTIONS AND CORRECT ANSWERS
Question:
1. Major components of Hemostasis
Answer:
- vascular wall (endothelium)
- platelets (thrombocytes)
- coagulation cascade (circulation)
Question:
2. Petechiae
Answer:
Pinpoint bruising; blood vessels.
Question:
3. Purpura
Answer:
Multiple pinpoint bruises (appearing slightly larger than petechiae); accumulation
of blood under the skin
Question:
4. Ecchymoses
Answer:
Average bruise from a good hit.
Question:
5. Agents able to initiate clot formation
Answer:
Intrinsic - Negatively charged surface; glass beads, platelet aggregation
(example).
Extrinsic - Tissue factor.
Question:
6. Five steps of Hemostasis
Answer:
- Vasoconstriction
- Platelets; Adhesion, activation, aggregation.
- Coagulation cascade > Thrombin cuts fibrinogen.
- Thrombin > Stabilizes clot.
- Counter-regulation; degrades clot when no longer needed.
, Question:
7. Primary hemostasis
Answer:
Platelet plug - damage to endothelial layer, exposing ECM > facilitating AAA.
Question:
8. Secondary hemostasis
Answer:
Stable clot formation - thrombin cleaves fibrinogen, forming a fibrin clot OR
activates platelets and reinforces platelet plug.
Question:
9. Anticoagulant endothelium functions
Answer:
- Inhibit platelets by hiding ECM.
- Inhibits Coagulation factors w/ heparin like molecules, Thrombomodulin, and
TFPI.
- Fibrinolysis; TTPA.
Question:
10. Procoagulant endothelium functions
Answer:
- vWF activation of platelets.
- TF activation of coagulation cascade.
- Plasminogen activator inhibitors.
Question:
11. Platelet adhesion explained
Answer:
Mediated by vWF interactions (bridge b/w platelet surface receptor and Ib and
collagen.
Question:
12. Platelet activation explained
Answer:
Platelets change shape > granules release:
- Ca++ > Coagulation factors.
- ADP > Platelet activator.
- TxA2 > activates more platelets, aggregation (AA metabolism).
