WGU D027 Comprehensive Study Guide
Autosomal Dominant 1 parent has, 50% chance of child having
Autosomal Recessive Both parents are carriers, 25% chance of child having, 50% chance child is a
carrier.
Cystic Fibrosis affects pancreas causing secretions in lungs
21st Trisomy Down Syndrome
Klinefelter Syndrome (XXY) male has extra X, female like qualities
Turner Syndrome Missing X in females
Alpha Thalassemia inherited blood disorder; mild to severe anemia
Beta Thalassemia low hemoglobin; contraindicated medication ferrous sulfate
Prevalence Risk proportion of the population affected at a certain time
Incidence rate number of new cases divided by population
Innate immunity inflammation; increased vascular permeability
B&T lymphocytes immune response
primary malignant tumor lack of organization of cells
glucocorticoids used in combination with other agent to treat lymphoid tissue (leukemia).
glucocorticoids are directly toxic to lymphoid tissues.
Selective estrogen receptor modulators (SERM) for hormone receptor positive and advanced breast cancer. (Tamoxifin reduces
risk and recurrence risk)
Heart failure impairment of the ventricle to fill with or eject blood; heart cannot meet metabolic
need of the body.
, WGU D027 Comprehensive Study Guide
CHF heart cannot keep up with metabolic needs; volume overload in pulmonary area
Left Ventricular Dysfunction reduced ejection fraction; ventricle having issue ejecting blood.
normal ejection fraction 55 - 60 % (blood pumped out with each heartbeat)
Ejection fraction of 50% - reduced or preserved? preserved
Diastolic CHF preserved ejection fraction, problem is with filling
Systolic CHF reduced ejection fraction, problem is with ejecting
Left sided CHF pulmonary (JVD, fluid volume overload, rails, S-3 murmurs) ** #1 cause of Right
sided CHF
BNP gold standard lab test to diagnose CHF
Echocardiogram Diagnostic tool, evaluates heart structure and function
At Risk for HF - Stage A no structural heart disease or symptoms of heart failure
Stage A HF co-morbidities htn, atherosclerotic disease, diabetes, metabolic syndrome, patients using
cardiotoxins with family history
Therapy goals of stage A HF treat htn, encourage smoking cessation, encourage regular exercise, treat lipid
disorders, discourage alcohol intake/drug use, control metabolic syndrome
At Risk for HF - Stage B structural heart disease but no symptoms of heart failure
Stage B HF co-morbidities previous MI, LV remodeling with LV hypertrophy and low EF, asymptomatic
valvular disease
Therapy goals of Stage B HF Meds: ACEI or ARB, Beta-blockers, implantable defibrillators
Stage C heart failure structural heart disease with prior or current symptoms of HF
Autosomal Dominant 1 parent has, 50% chance of child having
Autosomal Recessive Both parents are carriers, 25% chance of child having, 50% chance child is a
carrier.
Cystic Fibrosis affects pancreas causing secretions in lungs
21st Trisomy Down Syndrome
Klinefelter Syndrome (XXY) male has extra X, female like qualities
Turner Syndrome Missing X in females
Alpha Thalassemia inherited blood disorder; mild to severe anemia
Beta Thalassemia low hemoglobin; contraindicated medication ferrous sulfate
Prevalence Risk proportion of the population affected at a certain time
Incidence rate number of new cases divided by population
Innate immunity inflammation; increased vascular permeability
B&T lymphocytes immune response
primary malignant tumor lack of organization of cells
glucocorticoids used in combination with other agent to treat lymphoid tissue (leukemia).
glucocorticoids are directly toxic to lymphoid tissues.
Selective estrogen receptor modulators (SERM) for hormone receptor positive and advanced breast cancer. (Tamoxifin reduces
risk and recurrence risk)
Heart failure impairment of the ventricle to fill with or eject blood; heart cannot meet metabolic
need of the body.
, WGU D027 Comprehensive Study Guide
CHF heart cannot keep up with metabolic needs; volume overload in pulmonary area
Left Ventricular Dysfunction reduced ejection fraction; ventricle having issue ejecting blood.
normal ejection fraction 55 - 60 % (blood pumped out with each heartbeat)
Ejection fraction of 50% - reduced or preserved? preserved
Diastolic CHF preserved ejection fraction, problem is with filling
Systolic CHF reduced ejection fraction, problem is with ejecting
Left sided CHF pulmonary (JVD, fluid volume overload, rails, S-3 murmurs) ** #1 cause of Right
sided CHF
BNP gold standard lab test to diagnose CHF
Echocardiogram Diagnostic tool, evaluates heart structure and function
At Risk for HF - Stage A no structural heart disease or symptoms of heart failure
Stage A HF co-morbidities htn, atherosclerotic disease, diabetes, metabolic syndrome, patients using
cardiotoxins with family history
Therapy goals of stage A HF treat htn, encourage smoking cessation, encourage regular exercise, treat lipid
disorders, discourage alcohol intake/drug use, control metabolic syndrome
At Risk for HF - Stage B structural heart disease but no symptoms of heart failure
Stage B HF co-morbidities previous MI, LV remodeling with LV hypertrophy and low EF, asymptomatic
valvular disease
Therapy goals of Stage B HF Meds: ACEI or ARB, Beta-blockers, implantable defibrillators
Stage C heart failure structural heart disease with prior or current symptoms of HF
