Pediatrics Exam 4
Unit 9 Neurological and Cognitive, Endocrine
Chapter 25: Cognitive/Psychosocial Impairment pg. 847, ADHD: 855-856, Downs: 848, Autism: 848, 866-868,
Maltreatment: 857-859
Chapter 19: Endocrine pg. 633, DM1 pg. 665-672, DM2: 672, DKA: 674-677, Precocious Puberty: 648-649,
PKU: 864 + 360, Hypothyroidism: 653-654
Medications: Levothyroxine, Dextroamphetamine & Amphetamine & Lisdexamfetamine, Methylphenidate
Cognitive/Psychosocial Impairment
ADHD
o Pathophysiology/Etiology:
Unknown cause
Neurotransmitters DA (dopamine) and NE (norepinephrine) are thought to be involved
o Clinical Manifestations:
Inattention
Behaviors displaying hyperactivity
Impulsivity
o Diagnosis:
Medical & developmental history
Physical exam
Vision& hearing assessment
Detailed neurological evaluation
Behavior checklists
o Management: Three-Pronged Approach
Pharmacologic/medication:
Psychostimulants:
o Methylphenidate
o Dextroamphetamine
o Amphetamine
o Lisdexamfetamine
Behavioral Therapy
Prevention of undesired behavior/parenting skills
Counseling
Peer group work
Family therapy
Environmental Manipulation:
Environment modified to allow the child to be successful
, Down Syndrome, Trisomy 21
o Pathophysiology/Etiology:
Most common chromosomal abnormality: 47 chromosomes present, usually as Trisomy
of the 21st pair
Changes in the development of the body & brain
o Clinical Manifestations:
Poor muscle tone
Wide-spaced nipples
Slanting eyes
Hyperflexibility of the joints
Flat bridge of the nose
Short neck with extra folds of the skin
Small statures
Low-set ears
Simian crease
Protruding tongue
Cardiac: valve disease
Renal and radial abnormalities
Decreased immune function
o Diagnosis:
Chromosomal blood test
Low level of alpha-fetoprotein
DNA or karyotyping reveals 3 copies of chromosome 21
o Management:
Therapeutic/Nursing Management
Assist new parents with information & resources
Early intervention
, ASD (Autism Spectrum Disorder)
o Pathophysiology:
Continuum of disorders that involve limitations in social relatedness, verbal & nonverbal
communications, & range of interest & behaviors
o Etiology:
Unknown (not immunizations)
o Clinical Manifestations:
Impairment in social reciprocity
Inability to maintain eye contact
Impaired communication
Restrictive or repetitive behaviors, interests, or activities
o Diagnosis:
“First Signs” program
o Management:
Therapeutic/Nursing Management
Early Intervention
Be aware of the child’s physical boundaries & reluctance to be touched by
others
Routine is VERY important
Education:
CDC ALARM acronym as a means of understanding autism & its treatment
o A = autism is prevalent
o L = listen to patients/parents
o A = act early
o R = refer
o M = monitor
Maltreatment of Children
o Pathophysiology/Etiology:
Includes abuse and neglect of a child less than 18 years of age by anyone who is a
caregiver or in a custodial role
Physical, sexual, emotional abuse, or neglect
o Clinical Manifestations:
, o Diagnosis:
H&P
X-ray
Serum chem labs for infection, drug induction, toxicity
o Management:
Therapeutic/Nursing Management
Identify risk factors related to maltreatment
Teach parents and caregivers appropriate ways to discipline the child, about the
use of alcohol and drugs during pregnancy, and discourage caregivers from
substance use
Educate children and adolescents about the body and personal boundaries
Report suspected child abuse to the local enforcement agency and/or follow
clinical agency guidelines for reporting
Endocrine
Type 1 Diabetes
o Pathophysiology/Etiology:
Not preventable
Autoimmune disease that causes destruction of pancreatic cells that produce insulin
o Clinical Manifestations:
Polyuria
Polydipsia
Polyphagia
Skinny/weight loss
o Diagnosis:
Blood glucose:
< 2 yr: 60-100 mg/dL
>2yr: 70-110 mg/dL
HgBA1c:
<6%
o Management:
Unit 9 Neurological and Cognitive, Endocrine
Chapter 25: Cognitive/Psychosocial Impairment pg. 847, ADHD: 855-856, Downs: 848, Autism: 848, 866-868,
Maltreatment: 857-859
Chapter 19: Endocrine pg. 633, DM1 pg. 665-672, DM2: 672, DKA: 674-677, Precocious Puberty: 648-649,
PKU: 864 + 360, Hypothyroidism: 653-654
Medications: Levothyroxine, Dextroamphetamine & Amphetamine & Lisdexamfetamine, Methylphenidate
Cognitive/Psychosocial Impairment
ADHD
o Pathophysiology/Etiology:
Unknown cause
Neurotransmitters DA (dopamine) and NE (norepinephrine) are thought to be involved
o Clinical Manifestations:
Inattention
Behaviors displaying hyperactivity
Impulsivity
o Diagnosis:
Medical & developmental history
Physical exam
Vision& hearing assessment
Detailed neurological evaluation
Behavior checklists
o Management: Three-Pronged Approach
Pharmacologic/medication:
Psychostimulants:
o Methylphenidate
o Dextroamphetamine
o Amphetamine
o Lisdexamfetamine
Behavioral Therapy
Prevention of undesired behavior/parenting skills
Counseling
Peer group work
Family therapy
Environmental Manipulation:
Environment modified to allow the child to be successful
, Down Syndrome, Trisomy 21
o Pathophysiology/Etiology:
Most common chromosomal abnormality: 47 chromosomes present, usually as Trisomy
of the 21st pair
Changes in the development of the body & brain
o Clinical Manifestations:
Poor muscle tone
Wide-spaced nipples
Slanting eyes
Hyperflexibility of the joints
Flat bridge of the nose
Short neck with extra folds of the skin
Small statures
Low-set ears
Simian crease
Protruding tongue
Cardiac: valve disease
Renal and radial abnormalities
Decreased immune function
o Diagnosis:
Chromosomal blood test
Low level of alpha-fetoprotein
DNA or karyotyping reveals 3 copies of chromosome 21
o Management:
Therapeutic/Nursing Management
Assist new parents with information & resources
Early intervention
, ASD (Autism Spectrum Disorder)
o Pathophysiology:
Continuum of disorders that involve limitations in social relatedness, verbal & nonverbal
communications, & range of interest & behaviors
o Etiology:
Unknown (not immunizations)
o Clinical Manifestations:
Impairment in social reciprocity
Inability to maintain eye contact
Impaired communication
Restrictive or repetitive behaviors, interests, or activities
o Diagnosis:
“First Signs” program
o Management:
Therapeutic/Nursing Management
Early Intervention
Be aware of the child’s physical boundaries & reluctance to be touched by
others
Routine is VERY important
Education:
CDC ALARM acronym as a means of understanding autism & its treatment
o A = autism is prevalent
o L = listen to patients/parents
o A = act early
o R = refer
o M = monitor
Maltreatment of Children
o Pathophysiology/Etiology:
Includes abuse and neglect of a child less than 18 years of age by anyone who is a
caregiver or in a custodial role
Physical, sexual, emotional abuse, or neglect
o Clinical Manifestations:
, o Diagnosis:
H&P
X-ray
Serum chem labs for infection, drug induction, toxicity
o Management:
Therapeutic/Nursing Management
Identify risk factors related to maltreatment
Teach parents and caregivers appropriate ways to discipline the child, about the
use of alcohol and drugs during pregnancy, and discourage caregivers from
substance use
Educate children and adolescents about the body and personal boundaries
Report suspected child abuse to the local enforcement agency and/or follow
clinical agency guidelines for reporting
Endocrine
Type 1 Diabetes
o Pathophysiology/Etiology:
Not preventable
Autoimmune disease that causes destruction of pancreatic cells that produce insulin
o Clinical Manifestations:
Polyuria
Polydipsia
Polyphagia
Skinny/weight loss
o Diagnosis:
Blood glucose:
< 2 yr: 60-100 mg/dL
>2yr: 70-110 mg/dL
HgBA1c:
<6%
o Management: