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WGU D115 Objective Assessment Study Guide | Practice Questions & Rationales

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This WGU D115 Objective Assessment Study Guide provides structured review material for Advanced Pathophysiology for the Advanced Practice Nurse. Topics include disease states, disease progression, cellular and systems-level pathophysiology, disease etiology, physiological alterations, symptom assessment, clinical manifestations, and patient responses to changes in health. It is designed to help learners reinforce core concepts, strengthen clinical reasoning, identify knowledge gaps, and prepare effectively for the objective assessment. WGU describes D115 as Advanced Pathophysiology for the Advanced Practice Nurse.

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WGU D115 OBJECTIVE ASSESSMENT (OA) EXAM 2027 | ACTUAL
EXAM QUESTIONS WITH DETAILED ANSWERS WITH RATIONALES
AND A READINESS PRACTICE EXAM TEST BANK WITH A STUDY
GUIDE | LATEST UPDATED AND VERIFIED FOR GUARANTEED PASS


Which type of genetic disease affects males more frequently than females?



Sex-linked recessive
Autosomal recessive
Autosomal dominant
Sex-linked dominant - CORRECT ANSWER -Sex-Linked recessive. Since males only have one
X and one Y, if the affected chromosome has the illness, it will be expressed.



In which two conditions are chromosomal abnormalities the leading known cause?



Intellectual disability
Respiratory disorders
Fetal miscarriage
Cardiovascular disease
Mental illness
Check My Answer - CORRECT ANSWER -Intellectual disability and fetal miscarriage.
Chromosome abnormalities are the leading known cause of intellectual disability and fetal
miscarriage.



What are three examples of prenatal diagnostic studies?

Drug-sensitivity testing
Chorionic villus sampling (CVS)
Microscopy of cervical mucosa

, Preimplantation genetic testing (PGT)

Amniocentesis - CORRECT ANSWER -Chorionic villus sampling (CVS), amniocentesis, and
preimplantation genetic testing (PGT) are examples of prenatal diagnostic studies and are
performed in vitro. CVS is a form of genetic testing that provides genetic information found in
utero and is usually performed between weeks 11 and 14 of pregnancy. An amniocentesis is a
form of genetic testing that evaluates amniotic fluid and is usually performed during the second
trimester, between weeks 15 and 20 of pregnancy. PGT is performed on the embryo prior to
implantation.



Which genetic disorder is characterized by the presence of a zygote having one chromosome
with a normal complement of genes and one chromosome with a missing gene?

Klinefelter syndrome

Down syndrome

Cri du chat syndrome

Turner syndrome - CORRECT ANSWER -Cri du chat syndrome (translated as "cry of the cat") is
caused by a DNA deletion. This term describes the cry often heard from a baby affected by the
syndrome. Cri du chat syndrome can present as a microcephalic, low birth-weight baby with a
piercing cry.



How can an X-linked recessive disease skip generations?


Mothers cannot pass X-linked genes to their sons.
Females are hemizygous for the X chromosome.

The disease can be transmitted through female carriers.

These diseases need only one copy of the gene in females. - CORRECT ANSWER -The disease
can be transmitted through female carriers.



Since females have two copies of the X chromosome, the mother may provide an unaffected X to
a daughter or son. Furthermore, a daughter may not show signs of the disease because she has the
other X (the only X the father can give to a female) to cancel it out.

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