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Sumario Resumen Medical Biochemistry - Bioquímica

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Resumen Medical Biochemistry - Bioquímica Cap 40

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Cap. 40


RECEPTORES DE MEMBRANA Y
TRANSDUCCIÓN DE LA SEÑAL




Receptores intracelulares: hormonas esteroideas
Las hormonas esteroideas atraviesan las membranas celulares.

Debido a la estructura básica de colesterol que las conforma, las hormonas esteroideas como el cortisol
(sintetizado en el córtex de la glándula suprarrenal), las hormonas sexuales y la vitamina D pueden
atravesar la membrana plasmática de las células y ejercer su acción mediante receptores en el
citoplasma, denominados receptores de hormonas esteroideas.

Los receptores intracelulares para hormonas esteroideas y tiroideas y para los retinoides son factores de
transcripción: se unen a zonas reguladoras del ADN de determinados genes sensibles a una determinada


GALLEGO 3476-635468

, hormona esteroidea/tiroidea. Esta unión mediada por ligando causa un cambio conformacional de los
factores de transcripción que permite activar o reprimir la inducción de genes.



Receptores de membrana: receptores de hormonas polipeptídica




GALLEGO 3476-635468

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John Baynes Medical Biochemistry
Publisher: februari 2014 ISBN: 9781455745807 Edition: 1

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