NU 150 - Galen - Pharm Test 4-Questions
With 100% Correct Answers.
Sinemet (levodopa-carbidopa) - actions - Answer Used to treat Parkinson's
Dopaminergic Drug
Levodopa crosses the BBB (blood brain barrier) in small amounts→ converted into dopamine
(pleasure)
Levodopa if given with carbidopa, ↑ drug level that reaches the brain
Carbidopa has no affect when given alone
Sinemet is the combination of Levodopa/Carbidopa.
Carbidopa-conserves more dopamine
Levodopa-leaves more dopamine in the brain
Sinemet (levodopa-carbidopa) - Toxic ADRs - Answer Face or eyelid twitching
Tongue perfusion
Face grimacing
Means toxic levels of dopamine let HCP know
Sinemet (levodopa-carbidopa) - Patient Teaching - Answer Slow onset 2-6 weeks to become
effective
Slow position changes
Red, brown, urine, sweat and saliva=normal
No high protein meals
LEAVE-odopa-leave protein meals
CARB-odopa- carb it up
Not an elimination of tremors or rigidity just DECREASES
Never stop abruptly
Taken lifelong
Levodopa ((Larodopa)) - actions - Answer Used in management of Parkinson's
Levodopa crosses the BBB in small amounts→ converted into dopamine.
levodopa if given with carbidopa, ↑ drug level that reaches the brain
, Levodopa ((Larodopa)) - ADR - Answer During the early treatment with Levodopa and
Carbidopa adverse reactions are usually not seen.
GENERAL ADRs: dry mouth, dysphagia, anorexia, N/V, abdominal pain, constipation, hand
tremor, ↑headache and dizziness.
Most serious and frequent adverse drug reaction with Levodopa:
Choreiform movements→ involuntary twitching of the limbs or facial muscles.
Dystonic movements→ spasms that affect the tongue, jaw, eyes, and neck.
Levodopa ((Larodopa)) - drug interaction - Answer Levodopa may interact with many types of
drugs.
Vit B6 (pyridoxine): ↓effect of levodopa, no interaction effect if used with carbidopa.
Phenytoin (Anticonvulsant Drugs) - uses - Answer Hydantoins: phenytoin (DILANTIN)
most commonly prescribed.
some individuals respond well to one drug therapy, but in others, a combination of
anticonvulsants is needed.
also used for other diseases, for example bipolar, neuropathic pain, and anxiety
Adjustments to the medication may need to be made when the patient is under lots of stress,
severe illness, or when other drugs are being taken in combination with the anticonvulsants.
Phenytoin (Anticonvulsant Drugs) - toxic ranges - Answer 10-20 mcg/dl Therapeutic range
Below 10-seizure risk
Over 20 toxic risk-hold med and notify HCP
Routine blood tests
Take med same time daily same time narrow therapeutic range
Early signs to report to HCP for toxicity
Ataxia (unsteady gait)
Slurred speech
Hand tremor
Phenytoin (Anticonvulsant Drugs) - ADR - Answer ADRs
• Nystagmus-involuntary movement of the eyeball
Ataxia-loss of control of voluntary movements, mainly gait
Slurred speech
Skin Rash, fatigue, and dyspnea (priority)
N/V
With 100% Correct Answers.
Sinemet (levodopa-carbidopa) - actions - Answer Used to treat Parkinson's
Dopaminergic Drug
Levodopa crosses the BBB (blood brain barrier) in small amounts→ converted into dopamine
(pleasure)
Levodopa if given with carbidopa, ↑ drug level that reaches the brain
Carbidopa has no affect when given alone
Sinemet is the combination of Levodopa/Carbidopa.
Carbidopa-conserves more dopamine
Levodopa-leaves more dopamine in the brain
Sinemet (levodopa-carbidopa) - Toxic ADRs - Answer Face or eyelid twitching
Tongue perfusion
Face grimacing
Means toxic levels of dopamine let HCP know
Sinemet (levodopa-carbidopa) - Patient Teaching - Answer Slow onset 2-6 weeks to become
effective
Slow position changes
Red, brown, urine, sweat and saliva=normal
No high protein meals
LEAVE-odopa-leave protein meals
CARB-odopa- carb it up
Not an elimination of tremors or rigidity just DECREASES
Never stop abruptly
Taken lifelong
Levodopa ((Larodopa)) - actions - Answer Used in management of Parkinson's
Levodopa crosses the BBB in small amounts→ converted into dopamine.
levodopa if given with carbidopa, ↑ drug level that reaches the brain
, Levodopa ((Larodopa)) - ADR - Answer During the early treatment with Levodopa and
Carbidopa adverse reactions are usually not seen.
GENERAL ADRs: dry mouth, dysphagia, anorexia, N/V, abdominal pain, constipation, hand
tremor, ↑headache and dizziness.
Most serious and frequent adverse drug reaction with Levodopa:
Choreiform movements→ involuntary twitching of the limbs or facial muscles.
Dystonic movements→ spasms that affect the tongue, jaw, eyes, and neck.
Levodopa ((Larodopa)) - drug interaction - Answer Levodopa may interact with many types of
drugs.
Vit B6 (pyridoxine): ↓effect of levodopa, no interaction effect if used with carbidopa.
Phenytoin (Anticonvulsant Drugs) - uses - Answer Hydantoins: phenytoin (DILANTIN)
most commonly prescribed.
some individuals respond well to one drug therapy, but in others, a combination of
anticonvulsants is needed.
also used for other diseases, for example bipolar, neuropathic pain, and anxiety
Adjustments to the medication may need to be made when the patient is under lots of stress,
severe illness, or when other drugs are being taken in combination with the anticonvulsants.
Phenytoin (Anticonvulsant Drugs) - toxic ranges - Answer 10-20 mcg/dl Therapeutic range
Below 10-seizure risk
Over 20 toxic risk-hold med and notify HCP
Routine blood tests
Take med same time daily same time narrow therapeutic range
Early signs to report to HCP for toxicity
Ataxia (unsteady gait)
Slurred speech
Hand tremor
Phenytoin (Anticonvulsant Drugs) - ADR - Answer ADRs
• Nystagmus-involuntary movement of the eyeball
Ataxia-loss of control of voluntary movements, mainly gait
Slurred speech
Skin Rash, fatigue, and dyspnea (priority)
N/V
