ANCC FAMILY NURSE PRACTITIONER
(FNP) COMPREHENSIVE EXAM PREP
2026/2027 QUESTIONS AND ANSWERS
1. A 65-year-old patient presents with a sudden onset of severe headache, described as the
‘worst headache of my life.’ What is the most likely diagnosis?
A. Cluster headache
B. Migraine with aura
C. Temporal arteritis
D. Subarachnoid hemorrhage
Answer: D
Conceptual Explanation: A ‘thunderclap’ headache or ‘worst headache of my life’ is the
classic presentation for a subarachnoid hemorrhage, often due to a ruptured aneurysm.
2. Which of the following is the first-line treatment for a patient diagnosed with mild to
moderate Hidradenitis Suppurativa?
A. Oral Prednisone
B. Oral Isotretinoin
,C. Intravenous Vancomycin
D. Topical Clindamycin
Answer: D
Conceptual Explanation: Topical clindamycin is the first-line antibiotic treatment for
Hurley Stage I Hidradenitis Suppurativa.
3. In a patient with Chronic Kidney Disease, which medication class should be avoided to
prevent further decline in GFR?
A. NSAIDs
B. Beta Blockers
C. ACE Inhibitors
D. Statins
Answer: A
Conceptual Explanation: NSAIDs inhibit prostaglandins, which are necessary for
maintaining renal blood flow, potentially leading to acute kidney injury in CKD patients.
4. According to the JNC-8 guidelines, what is the blood pressure goal for a 62-year-old patient
with Diabetes Mellitus?
A. <120/80 mmHg
B. <130/80 mmHg
C. <140/90 mmHg
, D. <150/90 mmHg
Answer: C
Conceptual Explanation: JNC-8 recommends a target of <140/90 mmHg for adults with
diabetes or chronic kidney disease regardless of age.
5. A patient presents with a ‘strawberry tongue’ and a sandpaper-like rash. These findings are
most indicative of:
A. Kawasaki disease
B. Hand, foot, and mouth disease
C. Measles
D. Scarlet fever
Answer: D
Conceptual Explanation: Scarlet fever, caused by Group A Streptococcus, presents with a
sandpaper rash and strawberry tongue.
6. Which antidepressant is generally avoided in elderly patients due to its high anticholinergic
side effects and long half-life?
A. Amitriptyline
B. Escitalopram
C. Sertraline
D. Venlafaxine
(FNP) COMPREHENSIVE EXAM PREP
2026/2027 QUESTIONS AND ANSWERS
1. A 65-year-old patient presents with a sudden onset of severe headache, described as the
‘worst headache of my life.’ What is the most likely diagnosis?
A. Cluster headache
B. Migraine with aura
C. Temporal arteritis
D. Subarachnoid hemorrhage
Answer: D
Conceptual Explanation: A ‘thunderclap’ headache or ‘worst headache of my life’ is the
classic presentation for a subarachnoid hemorrhage, often due to a ruptured aneurysm.
2. Which of the following is the first-line treatment for a patient diagnosed with mild to
moderate Hidradenitis Suppurativa?
A. Oral Prednisone
B. Oral Isotretinoin
,C. Intravenous Vancomycin
D. Topical Clindamycin
Answer: D
Conceptual Explanation: Topical clindamycin is the first-line antibiotic treatment for
Hurley Stage I Hidradenitis Suppurativa.
3. In a patient with Chronic Kidney Disease, which medication class should be avoided to
prevent further decline in GFR?
A. NSAIDs
B. Beta Blockers
C. ACE Inhibitors
D. Statins
Answer: A
Conceptual Explanation: NSAIDs inhibit prostaglandins, which are necessary for
maintaining renal blood flow, potentially leading to acute kidney injury in CKD patients.
4. According to the JNC-8 guidelines, what is the blood pressure goal for a 62-year-old patient
with Diabetes Mellitus?
A. <120/80 mmHg
B. <130/80 mmHg
C. <140/90 mmHg
, D. <150/90 mmHg
Answer: C
Conceptual Explanation: JNC-8 recommends a target of <140/90 mmHg for adults with
diabetes or chronic kidney disease regardless of age.
5. A patient presents with a ‘strawberry tongue’ and a sandpaper-like rash. These findings are
most indicative of:
A. Kawasaki disease
B. Hand, foot, and mouth disease
C. Measles
D. Scarlet fever
Answer: D
Conceptual Explanation: Scarlet fever, caused by Group A Streptococcus, presents with a
sandpaper rash and strawberry tongue.
6. Which antidepressant is generally avoided in elderly patients due to its high anticholinergic
side effects and long half-life?
A. Amitriptyline
B. Escitalopram
C. Sertraline
D. Venlafaxine
