PATHO 370 - IN CLASS QUIZ 2 (CH. 10, 11, 13, 14, 15) EXAM QUESTIONS AND ANSWERS ALREADY GRADED
A+| 100% VERIFIED SOLUTIONS………...
Core Domains:
Hematologic Disorders and Coagulation
Alterations in Immune Function and Hypersensitivity
Oncologic Disorders and Leukemia
Cardiovascular Pathophysiology
Pulmonary Pathophysiology
Infectious Disease and Host Defense
Endocrine and Renal Systems
Diagnostic Markers and Clinical Manifestations
Introduction:
This comprehensive practice examination is designed to prepare students for the PATHO 370 In-Class Quiz 2,
covering Chapters 10, 11, 13, 14, and 15. It assesses foundational and applied knowledge of hematologic disorders,
immune system alterations, oncologic conditions, cardiovascular and pulmonary pathophysiology, and key
diagnostic markers. The exam employs multiple-choice and scenario-based questions that challenge students to
apply critical thinking, interpret clinical findings, and make sound pathophysiological judgments. Emphasis is
placed on real-world application, clinical reasoning, and the integration of core concepts necessary for successful
exam performance and competent nursing practice.
Section One: Questions 1–100
,1. Hemophilia B is also known as which of the following diseases?
A. Von Willebrand disease
B. Christmas disease
C. Hemolytic disease of the newborn
D. Disseminated intravascular coagulation
🟢 B. Christmas disease
🔴 RATIONALE: Hemophilia B is also known as Christmas disease, named after the first patient diagnosed with
the condition. It results from a deficiency of clotting factor IX.
2. Which laboratory finding is characteristic of anemia related to vitamin B₁₂ or folate deficiency?
A. Microcytic, hypochromic red blood cells
B. Normocytic, normochromic red blood cells
C. Macrocytic, normochromic red blood cells
D. Microcytic, normochromic red blood cells
🟢 C. Macrocytic, normochromic red blood cells
🔴 RATIONALE: Vitamin B₁₂ and folate deficiency anemias are characterized by macrocytic (large),
normochromic red blood cells due to impaired DNA synthesis. Iron deficiency anemia presents with microcytic,
hypochromic cells.
,3. What is the most common cause of anemia worldwide?
A. Vitamin B₁₂ deficiency
B. Folate deficiency
C. Iron deficiency
D. Chronic disease
🟢 C. Iron deficiency
🔴 RATIONALE: Iron deficiency is the most common form of anemia globally. It results from inadequate iron
intake, blood loss, or impaired absorption, leading to microcytic, hypochromic red blood cells.
4. The Philadelphia chromosome is a balanced chromosome translocation that forms a new gene called:
A. bcr-abl
B. p53
C. RAS
D. MYC
🟢 A. bcr-abl
🔴 RATIONALE: The Philadelphia chromosome results from a translocation between chromosomes 9 and 22,
creating the bcr-abl fusion gene. This gene produces a constitutively active tyrosine kinase that drives the
proliferation of leukemic cells in chronic myeloid leukemia (CML).
, 5. Which form of leukemia demonstrates the presence of the Philadelphia chromosome?
A. Acute lymphoid leukemia (ALL)
B. Chronic myeloid leukemia (CML)
C. Acute myeloid leukemia (AML)
D. Hairy cell leukemia
🟢 B. Chronic myeloid leukemia (CML)
🔴 RATIONALE: The Philadelphia chromosome is a hallmark of chronic myeloid leukemia (CML), present in over
95% of cases. It results from the t(9;22) translocation and produces the bcr-abl fusion gene.
6. A patient is diagnosed with pernicious anemia. This condition is caused by a lack of:
A. Intrinsic factor
B. Dietary iron
C. Vitamin C
D. Folic acid
🟢 A. Intrinsic factor
🔴 RATIONALE: Pernicious anemia is caused by a lack of intrinsic factor, which is produced by parietal cells in
the stomach. Intrinsic factor is necessary for the absorption of vitamin B₁₂ in the ileum.
A+| 100% VERIFIED SOLUTIONS………...
Core Domains:
Hematologic Disorders and Coagulation
Alterations in Immune Function and Hypersensitivity
Oncologic Disorders and Leukemia
Cardiovascular Pathophysiology
Pulmonary Pathophysiology
Infectious Disease and Host Defense
Endocrine and Renal Systems
Diagnostic Markers and Clinical Manifestations
Introduction:
This comprehensive practice examination is designed to prepare students for the PATHO 370 In-Class Quiz 2,
covering Chapters 10, 11, 13, 14, and 15. It assesses foundational and applied knowledge of hematologic disorders,
immune system alterations, oncologic conditions, cardiovascular and pulmonary pathophysiology, and key
diagnostic markers. The exam employs multiple-choice and scenario-based questions that challenge students to
apply critical thinking, interpret clinical findings, and make sound pathophysiological judgments. Emphasis is
placed on real-world application, clinical reasoning, and the integration of core concepts necessary for successful
exam performance and competent nursing practice.
Section One: Questions 1–100
,1. Hemophilia B is also known as which of the following diseases?
A. Von Willebrand disease
B. Christmas disease
C. Hemolytic disease of the newborn
D. Disseminated intravascular coagulation
🟢 B. Christmas disease
🔴 RATIONALE: Hemophilia B is also known as Christmas disease, named after the first patient diagnosed with
the condition. It results from a deficiency of clotting factor IX.
2. Which laboratory finding is characteristic of anemia related to vitamin B₁₂ or folate deficiency?
A. Microcytic, hypochromic red blood cells
B. Normocytic, normochromic red blood cells
C. Macrocytic, normochromic red blood cells
D. Microcytic, normochromic red blood cells
🟢 C. Macrocytic, normochromic red blood cells
🔴 RATIONALE: Vitamin B₁₂ and folate deficiency anemias are characterized by macrocytic (large),
normochromic red blood cells due to impaired DNA synthesis. Iron deficiency anemia presents with microcytic,
hypochromic cells.
,3. What is the most common cause of anemia worldwide?
A. Vitamin B₁₂ deficiency
B. Folate deficiency
C. Iron deficiency
D. Chronic disease
🟢 C. Iron deficiency
🔴 RATIONALE: Iron deficiency is the most common form of anemia globally. It results from inadequate iron
intake, blood loss, or impaired absorption, leading to microcytic, hypochromic red blood cells.
4. The Philadelphia chromosome is a balanced chromosome translocation that forms a new gene called:
A. bcr-abl
B. p53
C. RAS
D. MYC
🟢 A. bcr-abl
🔴 RATIONALE: The Philadelphia chromosome results from a translocation between chromosomes 9 and 22,
creating the bcr-abl fusion gene. This gene produces a constitutively active tyrosine kinase that drives the
proliferation of leukemic cells in chronic myeloid leukemia (CML).
, 5. Which form of leukemia demonstrates the presence of the Philadelphia chromosome?
A. Acute lymphoid leukemia (ALL)
B. Chronic myeloid leukemia (CML)
C. Acute myeloid leukemia (AML)
D. Hairy cell leukemia
🟢 B. Chronic myeloid leukemia (CML)
🔴 RATIONALE: The Philadelphia chromosome is a hallmark of chronic myeloid leukemia (CML), present in over
95% of cases. It results from the t(9;22) translocation and produces the bcr-abl fusion gene.
6. A patient is diagnosed with pernicious anemia. This condition is caused by a lack of:
A. Intrinsic factor
B. Dietary iron
C. Vitamin C
D. Folic acid
🟢 A. Intrinsic factor
🔴 RATIONALE: Pernicious anemia is caused by a lack of intrinsic factor, which is produced by parietal cells in
the stomach. Intrinsic factor is necessary for the absorption of vitamin B₁₂ in the ileum.
