NSG 5442 EXAM 3 STUDY GUIDE QUESTIONS
AND ANSWERS FALL 2025/2026 UPDATE 100%
CORRECT - SOUTH COLLEGE.
180 QUESTIONS
TABLE OF CONTENTS
Analyze complex clinical scenarios to Integrate pathophysiological principles into
formulate evidence-based nursing advanced assessment and care planning
Q1 - patient on a stable dose Q35 - finding is most indicative of
Q2 - a patient with sepsis and Q36 - patient with sepsis develops acute
Q3 - of the following findings is Q37 - of the following best describes
Q4 - patient with type 2 diabetes Q38 - patient with heart failure with
Q5 - of the following best describes Q39 - of the following is the
Q6 - patient with cirrhosis and ascites Q40 - patient with chronic obstructive pulmonary
Q7 - of the following is the Q41 - patient with chronic heart failure
Q8 - patient with chronic heart failure Q42 - pathophysiological mechanism best explain...
Q9 - of the following assessment findings Q43 - patient on vancomycin develops acute
Q10 - patient with asthma is prescribed Q44 - a patient with suspected sepsis,
Q11 - a patient with an acute Q45 - of the following interventions is
Q12 - patient on a ketogenic diet Q46 - patient with atrial fibrillation is
Q13 - pharmacologic strategy is most appropriate Q47 - patient with type 2 diabetes
Q14 - patient with septic shock remains Q48 - evidence-based intervention is most effec...
Q15 - electrocardiographic finding is most spec... Q49 - patient is receiving a continuous
Q16 - patient with acute respiratory distress Q50 - of the following best describes
Q17 - finding is most consistent with Q51 - critically ill patient with septic
Evaluate pharmacological and Critically appraise current research and
non-pharmacological management guidelines to inform nursing practice
Q18 - patient with chronic kidney disease Q52 - finding most clearly distinguishes acute
Q19 - statement best reflects the current Q53 - patient with acute pancreatitis develops
Q20 - a patient with suspected acute Q54 - electrocardiographic finding is most spec...
Q21 - research team is designing a Q55 - patient with cirrhosis and refractory
Q22 - patient with type 2 diabetes Q56 - ventilator setting adjustment is most
Q23 - critically ill adults, which transfusion Q57 - patient with diabetic ketoacidosis has
Q24 - hospital is implementing a sepsis Q58 - patient with septic shock remains
Q25 - nurse practitioner is evaluating a Q59 - combination of findings is most
Q26 - patient is prescribed a medication Q60 - patient with acute liver failure
Q27 - a patient with acute decompensated Q61 - the context of a sudden
Q28 - patient is receiving IV norepinephrine Q62 - patient presents with high-output ileostomy
Q29 - of the following represents the Q63 - patient with acute respiratory distress
Q30 - patient with chronic kidney disease Q64 - of the following best describes
Q31 - patient with stage IV pancreatic Q65 - patient in the ICU develops
Q32 - a patient with acute respiratory Q66 - of the following laboratory findings
Q33 - pharmacokinetic parameter is most altered Q67 - patient with severe sepsis is
Q34 - patient with type 2 diabetes Q68 - of the following is the
Page 1
,NSG 5442 Exam 3 Study Guide Questions South College.
and Answers Fall 2025 Q101 - patient with severe sepsis and
Q69 - patient with suspected acute coronary Q102 - a patient with acute kidney
Q70 - patient in the intensive care Q103 - patient with cirrhosis and refractory
Q71 - a patient with suspected heparin-induced Q104 - patient on mechanical ventilation with
Q72 - patient with acute respiratory distress Q105 - patient with a Glasgow Coma
Q73 - assessment finding in a patient Q106 - patient with diabetic ketoacidosis is
Q74 - patient with septic shock remains Q107 - patient with a subarachnoid hemorrhage
Q75 - finding is most consistent with Q108 - patient with septic shock has
Q76 - patient with acute kidney injury Q109 - patient with acute pancreatitis develops
Q77 - statement regarding the use of Q110 - patient is admitted with a
Q78 - a patient with acute pancreatitis, Q111 - patient with cirrhosis and refractory
Q79 - intervention is most effective in Q112 - pathophysiologic mechanism best explains the
Q80 - patient with diabetic ketoacidosis (DKA) Q113 - a patient with septic shock
Q81 - a patient with refractory hypertension Q114 - finding in a patient with
Q82 - patient with type 2 diabetes Q115 - patient with refractory hypoxemia (PaO2/FiO2
Q83 - combination of findings best distinguishes Q116 - combination of factors most accurately
Q84 - patient on warfarin for mechanical
Foundations of Nursing (Advanced Practice)
2026 Update 100% Correct Q117 - patient with acute-on-chronic liver failure
Q85 - pharmacologic strategy is most effective Q118 - intervention has been shown to
Q86 - patient with generalized anxiety disorder Q119 - patient with severe sepsis develops
Q87 - finding most strongly indicates that Q120 - statement best reflects the current
Q88 - ECG finding is most specific Q121 - a patient with acute severe
Q89 - patient with cirrhosis and ascites Q122 - clinical finding most reliably distinguishes
Q90 - laboratory value is most consistent Q123 - patient with acute pancreatitis develops
Q91 - a patient with massive pulmonary Q124 - of the following hemodynamic profiles
Q92 - patient with acute decompensated heart Q125 - patient with septic shock remains
Q93 - managing a patient with septic Q126 - patient with a serum potassium
Q94 - of the following best explains Q127 - of the following acid-base disturbances
Q95 - a patient with acute respiratory Q128 - managing a patient with acute
Q96 - patient with acute kidney injury Q129 - patient with suspected acute coronary
Q97 - of the following acid-base disturbances Q130 - patient with diabetic ketoacidosis has
Q98 - a patient with hyperkalemia and Q131 - a patient with septic shock
Q99 - patient with cirrhosis and ascites Q132 - patient with acute respiratory distress
Q100 - of the following ventilator settings
Applied Nursing (Advanced Practice)
Q133 - combination of findings is most
Q134 - patient with acute decompensated heart
Q135 - ethical principle is most directly
Q136 - patient with severe preeclampsia is
Q137 - patient on vancomycin has a
Q138 - patient presentation is most consistent
Q139 - patient with diabetic ketoacidosis (DKA)
Q140 - patient with a pulmonary embolism
Q141 - the management of status epilepticus,
Q142 - of the following best explains
Q143 - patient with acute decompensated heart
Q144 - of the following laboratory findings
Q145 - a patient with acute kidney
Q146 - of the following is the
Q147 - of the following best describes
Q148 - of the following is the
Page 2
,Advanced Nursing (Advanced Practice)
Q149 - a patient with sepsis and
Q150 - of the following is the
Q151 - a patient with septic shock
Q152 - of the following best explains
Q153 - patient with severe hyperkalemia (K+
Q154 - finding is most consistent with
Q155 - patient with cirrhosis and ascites
Q156 - of the following is the
Q157 - patient on continuous renal replacement
Q158 - of the following is the
Q159 - patient with acute pancreatitis develops
Q160 - of the following interventions has
Q161 - a patient with acute ischemic
Q162 - patient with sepsis and acute
Q163 - of the following best describes
Q164 - patient with chronic heart failure
Nursing (Advanced Practice) Review
Q165 - a patient with suspected acute
Q166 - patient with type 2 diabetes
Q167 - patient with a history of
Q168 - of the following best describes
Q169 - patient with severe sepsis is
Q170 - For a patient with acute
Q171 - a patient with septic shock
Q172 - pathophysiological mechanism best explain...
Q173 - patient with acute respiratory distress
Q174 - finding is most indicative of
Q175 - patient with diabetic ketoacidosis (DKA)
Q176 - ventilator setting change is most
Q177 - patient with severe sepsis is
Q178 - of the following is a
Q179 - statement best describes the recommended
Q180 - patient with septic shock is
Page 3
, Q1 ANALYZE COMPLEX CLINICAL SCENARIOS TO FORMULATE EVIDENCE-BASED
NURSING INTERVENTIONS
A patient on a stable dose of warfarin is started on amiodarone for atrial
fibrillation. Three days later, the INR is 4.5. What is the most appropriate
pharmacologic explanation for this interaction?
A. Amiodarone inhibits CYP2C9, reducing warfarin metabolism CORRECT
B. Amiodarone displaces warfarin from plasma protein binding sites
C. Amiodarone induces CYP3A4, increasing warfarin clearance
D. Amiodarone antagonizes vitamin K, potentiating warfarin effect
RATIONALE: Amiodarone is a potent inhibitor of CYP2C9, the primary enzyme that metabolizes
the S-enantiomer of warfarin, leading to increased warfarin levels and INR. While amiodarone
also inhibits CYP3A4 and P-glycoprotein, the major interaction is via CYP2C9 inhibition.
Displacement from protein binding is not the primary mechanism, and induction would lower INR.
Q2 ANALYZE COMPLEX CLINICAL SCENARIOS TO FORMULATE EVIDENCE-BASED
NURSING INTERVENTIONS
In a patient with sepsis and acute kidney injury, which parameter is most
indicative of adequate tissue perfusion despite normal blood pressure?
A. Central venous pressure of 8 mmHg
B. Lactate clearance of 20% over 6 hours CORRECT
C. Urine output of 0.3 mL/kg/hr
D. Mixed venous oxygen saturation of 55%
RATIONALE: Lactate clearance is a direct marker of tissue hypoxia and perfusion; a decrease of
at least 10-20% over 6 hours indicates improving perfusion. Central venous pressure reflects
preload, not perfusion. Urine output may lag and can be confounded by diuretics. ScvO2 < 70%
suggests inadequate perfusion, so 55% would be concerning.
Page 4
AND ANSWERS FALL 2025/2026 UPDATE 100%
CORRECT - SOUTH COLLEGE.
180 QUESTIONS
TABLE OF CONTENTS
Analyze complex clinical scenarios to Integrate pathophysiological principles into
formulate evidence-based nursing advanced assessment and care planning
Q1 - patient on a stable dose Q35 - finding is most indicative of
Q2 - a patient with sepsis and Q36 - patient with sepsis develops acute
Q3 - of the following findings is Q37 - of the following best describes
Q4 - patient with type 2 diabetes Q38 - patient with heart failure with
Q5 - of the following best describes Q39 - of the following is the
Q6 - patient with cirrhosis and ascites Q40 - patient with chronic obstructive pulmonary
Q7 - of the following is the Q41 - patient with chronic heart failure
Q8 - patient with chronic heart failure Q42 - pathophysiological mechanism best explain...
Q9 - of the following assessment findings Q43 - patient on vancomycin develops acute
Q10 - patient with asthma is prescribed Q44 - a patient with suspected sepsis,
Q11 - a patient with an acute Q45 - of the following interventions is
Q12 - patient on a ketogenic diet Q46 - patient with atrial fibrillation is
Q13 - pharmacologic strategy is most appropriate Q47 - patient with type 2 diabetes
Q14 - patient with septic shock remains Q48 - evidence-based intervention is most effec...
Q15 - electrocardiographic finding is most spec... Q49 - patient is receiving a continuous
Q16 - patient with acute respiratory distress Q50 - of the following best describes
Q17 - finding is most consistent with Q51 - critically ill patient with septic
Evaluate pharmacological and Critically appraise current research and
non-pharmacological management guidelines to inform nursing practice
Q18 - patient with chronic kidney disease Q52 - finding most clearly distinguishes acute
Q19 - statement best reflects the current Q53 - patient with acute pancreatitis develops
Q20 - a patient with suspected acute Q54 - electrocardiographic finding is most spec...
Q21 - research team is designing a Q55 - patient with cirrhosis and refractory
Q22 - patient with type 2 diabetes Q56 - ventilator setting adjustment is most
Q23 - critically ill adults, which transfusion Q57 - patient with diabetic ketoacidosis has
Q24 - hospital is implementing a sepsis Q58 - patient with septic shock remains
Q25 - nurse practitioner is evaluating a Q59 - combination of findings is most
Q26 - patient is prescribed a medication Q60 - patient with acute liver failure
Q27 - a patient with acute decompensated Q61 - the context of a sudden
Q28 - patient is receiving IV norepinephrine Q62 - patient presents with high-output ileostomy
Q29 - of the following represents the Q63 - patient with acute respiratory distress
Q30 - patient with chronic kidney disease Q64 - of the following best describes
Q31 - patient with stage IV pancreatic Q65 - patient in the ICU develops
Q32 - a patient with acute respiratory Q66 - of the following laboratory findings
Q33 - pharmacokinetic parameter is most altered Q67 - patient with severe sepsis is
Q34 - patient with type 2 diabetes Q68 - of the following is the
Page 1
,NSG 5442 Exam 3 Study Guide Questions South College.
and Answers Fall 2025 Q101 - patient with severe sepsis and
Q69 - patient with suspected acute coronary Q102 - a patient with acute kidney
Q70 - patient in the intensive care Q103 - patient with cirrhosis and refractory
Q71 - a patient with suspected heparin-induced Q104 - patient on mechanical ventilation with
Q72 - patient with acute respiratory distress Q105 - patient with a Glasgow Coma
Q73 - assessment finding in a patient Q106 - patient with diabetic ketoacidosis is
Q74 - patient with septic shock remains Q107 - patient with a subarachnoid hemorrhage
Q75 - finding is most consistent with Q108 - patient with septic shock has
Q76 - patient with acute kidney injury Q109 - patient with acute pancreatitis develops
Q77 - statement regarding the use of Q110 - patient is admitted with a
Q78 - a patient with acute pancreatitis, Q111 - patient with cirrhosis and refractory
Q79 - intervention is most effective in Q112 - pathophysiologic mechanism best explains the
Q80 - patient with diabetic ketoacidosis (DKA) Q113 - a patient with septic shock
Q81 - a patient with refractory hypertension Q114 - finding in a patient with
Q82 - patient with type 2 diabetes Q115 - patient with refractory hypoxemia (PaO2/FiO2
Q83 - combination of findings best distinguishes Q116 - combination of factors most accurately
Q84 - patient on warfarin for mechanical
Foundations of Nursing (Advanced Practice)
2026 Update 100% Correct Q117 - patient with acute-on-chronic liver failure
Q85 - pharmacologic strategy is most effective Q118 - intervention has been shown to
Q86 - patient with generalized anxiety disorder Q119 - patient with severe sepsis develops
Q87 - finding most strongly indicates that Q120 - statement best reflects the current
Q88 - ECG finding is most specific Q121 - a patient with acute severe
Q89 - patient with cirrhosis and ascites Q122 - clinical finding most reliably distinguishes
Q90 - laboratory value is most consistent Q123 - patient with acute pancreatitis develops
Q91 - a patient with massive pulmonary Q124 - of the following hemodynamic profiles
Q92 - patient with acute decompensated heart Q125 - patient with septic shock remains
Q93 - managing a patient with septic Q126 - patient with a serum potassium
Q94 - of the following best explains Q127 - of the following acid-base disturbances
Q95 - a patient with acute respiratory Q128 - managing a patient with acute
Q96 - patient with acute kidney injury Q129 - patient with suspected acute coronary
Q97 - of the following acid-base disturbances Q130 - patient with diabetic ketoacidosis has
Q98 - a patient with hyperkalemia and Q131 - a patient with septic shock
Q99 - patient with cirrhosis and ascites Q132 - patient with acute respiratory distress
Q100 - of the following ventilator settings
Applied Nursing (Advanced Practice)
Q133 - combination of findings is most
Q134 - patient with acute decompensated heart
Q135 - ethical principle is most directly
Q136 - patient with severe preeclampsia is
Q137 - patient on vancomycin has a
Q138 - patient presentation is most consistent
Q139 - patient with diabetic ketoacidosis (DKA)
Q140 - patient with a pulmonary embolism
Q141 - the management of status epilepticus,
Q142 - of the following best explains
Q143 - patient with acute decompensated heart
Q144 - of the following laboratory findings
Q145 - a patient with acute kidney
Q146 - of the following is the
Q147 - of the following best describes
Q148 - of the following is the
Page 2
,Advanced Nursing (Advanced Practice)
Q149 - a patient with sepsis and
Q150 - of the following is the
Q151 - a patient with septic shock
Q152 - of the following best explains
Q153 - patient with severe hyperkalemia (K+
Q154 - finding is most consistent with
Q155 - patient with cirrhosis and ascites
Q156 - of the following is the
Q157 - patient on continuous renal replacement
Q158 - of the following is the
Q159 - patient with acute pancreatitis develops
Q160 - of the following interventions has
Q161 - a patient with acute ischemic
Q162 - patient with sepsis and acute
Q163 - of the following best describes
Q164 - patient with chronic heart failure
Nursing (Advanced Practice) Review
Q165 - a patient with suspected acute
Q166 - patient with type 2 diabetes
Q167 - patient with a history of
Q168 - of the following best describes
Q169 - patient with severe sepsis is
Q170 - For a patient with acute
Q171 - a patient with septic shock
Q172 - pathophysiological mechanism best explain...
Q173 - patient with acute respiratory distress
Q174 - finding is most indicative of
Q175 - patient with diabetic ketoacidosis (DKA)
Q176 - ventilator setting change is most
Q177 - patient with severe sepsis is
Q178 - of the following is a
Q179 - statement best describes the recommended
Q180 - patient with septic shock is
Page 3
, Q1 ANALYZE COMPLEX CLINICAL SCENARIOS TO FORMULATE EVIDENCE-BASED
NURSING INTERVENTIONS
A patient on a stable dose of warfarin is started on amiodarone for atrial
fibrillation. Three days later, the INR is 4.5. What is the most appropriate
pharmacologic explanation for this interaction?
A. Amiodarone inhibits CYP2C9, reducing warfarin metabolism CORRECT
B. Amiodarone displaces warfarin from plasma protein binding sites
C. Amiodarone induces CYP3A4, increasing warfarin clearance
D. Amiodarone antagonizes vitamin K, potentiating warfarin effect
RATIONALE: Amiodarone is a potent inhibitor of CYP2C9, the primary enzyme that metabolizes
the S-enantiomer of warfarin, leading to increased warfarin levels and INR. While amiodarone
also inhibits CYP3A4 and P-glycoprotein, the major interaction is via CYP2C9 inhibition.
Displacement from protein binding is not the primary mechanism, and induction would lower INR.
Q2 ANALYZE COMPLEX CLINICAL SCENARIOS TO FORMULATE EVIDENCE-BASED
NURSING INTERVENTIONS
In a patient with sepsis and acute kidney injury, which parameter is most
indicative of adequate tissue perfusion despite normal blood pressure?
A. Central venous pressure of 8 mmHg
B. Lactate clearance of 20% over 6 hours CORRECT
C. Urine output of 0.3 mL/kg/hr
D. Mixed venous oxygen saturation of 55%
RATIONALE: Lactate clearance is a direct marker of tissue hypoxia and perfusion; a decrease of
at least 10-20% over 6 hours indicates improving perfusion. Central venous pressure reflects
preload, not perfusion. Urine output may lag and can be confounded by diuretics. ScvO2 < 70%
suggests inadequate perfusion, so 55% would be concerning.
Page 4
