lOMoARcPSD|50131128
Neonatal Pharmacology Review - Fannp
Practicum II: Neonatal Np
, lOMoARcPSD|50131128
B15
Neonatal Pharmacology Review
Session Summary
This presentation will provide a general overview of pharmacokinetics, pharmacodynamics, and common
medications used in neonatal medicine to help prepare the participant for certification exams.
Session Objectives
Upon completion of this presentation, the participant will be able to:
describe the principles of pharmacology and how these differ in the fetus and neonate;
identify drugs used in the NICU, their indications and significant side effects;
identify drugs used in resuscitation;
understand how drugs given to the mother may affect the fetus.
Test Questions
1. When comparing a premature infant to a older infant’s extracellular fluid volume, the volume of
distribution for a water-soluble drug in a premature infant would be:
a. equal
b. greater
c. less
2. A drug that is un-ionized:
a. is unable to cross to the placenta
b. will cross the placenta less readily
c. will cross the placenta more readily
3. What change in a medication’s scheduling would need to happen in a premature infant with a
decreased glomerular filtration rate (GFR)?
a. decreased loading dose
b. lengthened dosing interval
c. shortened dosing interval
4. When using epinephrine in a resuscitation it is important to remember:
a. that it decreases O2 consumption of heart muscle
b. that it increases peripheral dilation
c. that ventilation must be established
, lOMoARcPSD|50131128
5. Dobutamine will:
a. decrease peripheral vascular resistance
b. does not change peripheral vascular resistance
c. Increase peripheral vascular resistance
6. Which of the following diuretics has been associated with the most significant sensorineural hearing
loss?
a. Bumex
b. Lasix
c. Chlorothiazide
7. An infant is receiving Gangiclovir, the NNP should monitor the infant most closely for:
a. anemia
b. neutropenia
c. renal failure
8. Which of the following antibiotics should be used to treat Chlamydia eye infection?
a. erythromycin
b. gentamicin
c. streptomycin
9. Which of the following drugs is a proton pump inhibitor that blocks gastric H+ secretion into the
gastric lumen?
a. metroclopramide
b. omeprazole
c. rantidine
References
American Academy of Pediatrics (2011). Neonatal resuscitation textbook.
Blackburn, S.T. (2007). Pharmacology and pharmacokinetics during the perinatal period. In Maternal, fetal & neonatal physiology:
A clinical perspective. St. Louis: Saunders/Elsevier.
Cloherty, J.P., Eicherwald, E.C. & Stark, A.R. (2008). Manual of neonatal care. Philadelphia: Wolters Kluwer/Lippincott Williams &
Wilkins.
Hibbs, A.M. (2011). Pharmacotherapy for gastroesophageal reflux disease. Neoreviews, 12(3): 159-163.
Martin, R.J., Fanaroff, A.A. & Walsh, M.C. (2011). Neonatal-perinatal medicine, diseases of fetus & neonate. St. Louis: Elsevier-
Mosby.
Neofax (2011). Montvatle: Thomson Reuters.
Reiter, P.D. (2002). Neonatal pharmacology and pharmacokinetics. NeoReviews, 3(11): E229.
Skinner, A.V. (2010). Neonatal pharmacology. Anaethesia and Intensive Care Medicine, 12(3): 79-84.
Takemoto, C.K., Hodding, J.H. & Kraus, D.M. (2012). Pediatric & neonatal dosage handbook. Hudson: Lexicomp.
Yaffe, S.J. & Aranda, J.V. (2011). Neonatal & pediatric pharmacology. Philadelphia: Lippincott Williams & Wilkins.
Session Outline
See handout on following pages.
Neonatal Pharmacology Review - Fannp
Practicum II: Neonatal Np
, lOMoARcPSD|50131128
B15
Neonatal Pharmacology Review
Session Summary
This presentation will provide a general overview of pharmacokinetics, pharmacodynamics, and common
medications used in neonatal medicine to help prepare the participant for certification exams.
Session Objectives
Upon completion of this presentation, the participant will be able to:
describe the principles of pharmacology and how these differ in the fetus and neonate;
identify drugs used in the NICU, their indications and significant side effects;
identify drugs used in resuscitation;
understand how drugs given to the mother may affect the fetus.
Test Questions
1. When comparing a premature infant to a older infant’s extracellular fluid volume, the volume of
distribution for a water-soluble drug in a premature infant would be:
a. equal
b. greater
c. less
2. A drug that is un-ionized:
a. is unable to cross to the placenta
b. will cross the placenta less readily
c. will cross the placenta more readily
3. What change in a medication’s scheduling would need to happen in a premature infant with a
decreased glomerular filtration rate (GFR)?
a. decreased loading dose
b. lengthened dosing interval
c. shortened dosing interval
4. When using epinephrine in a resuscitation it is important to remember:
a. that it decreases O2 consumption of heart muscle
b. that it increases peripheral dilation
c. that ventilation must be established
, lOMoARcPSD|50131128
5. Dobutamine will:
a. decrease peripheral vascular resistance
b. does not change peripheral vascular resistance
c. Increase peripheral vascular resistance
6. Which of the following diuretics has been associated with the most significant sensorineural hearing
loss?
a. Bumex
b. Lasix
c. Chlorothiazide
7. An infant is receiving Gangiclovir, the NNP should monitor the infant most closely for:
a. anemia
b. neutropenia
c. renal failure
8. Which of the following antibiotics should be used to treat Chlamydia eye infection?
a. erythromycin
b. gentamicin
c. streptomycin
9. Which of the following drugs is a proton pump inhibitor that blocks gastric H+ secretion into the
gastric lumen?
a. metroclopramide
b. omeprazole
c. rantidine
References
American Academy of Pediatrics (2011). Neonatal resuscitation textbook.
Blackburn, S.T. (2007). Pharmacology and pharmacokinetics during the perinatal period. In Maternal, fetal & neonatal physiology:
A clinical perspective. St. Louis: Saunders/Elsevier.
Cloherty, J.P., Eicherwald, E.C. & Stark, A.R. (2008). Manual of neonatal care. Philadelphia: Wolters Kluwer/Lippincott Williams &
Wilkins.
Hibbs, A.M. (2011). Pharmacotherapy for gastroesophageal reflux disease. Neoreviews, 12(3): 159-163.
Martin, R.J., Fanaroff, A.A. & Walsh, M.C. (2011). Neonatal-perinatal medicine, diseases of fetus & neonate. St. Louis: Elsevier-
Mosby.
Neofax (2011). Montvatle: Thomson Reuters.
Reiter, P.D. (2002). Neonatal pharmacology and pharmacokinetics. NeoReviews, 3(11): E229.
Skinner, A.V. (2010). Neonatal pharmacology. Anaethesia and Intensive Care Medicine, 12(3): 79-84.
Takemoto, C.K., Hodding, J.H. & Kraus, D.M. (2012). Pediatric & neonatal dosage handbook. Hudson: Lexicomp.
Yaffe, S.J. & Aranda, J.V. (2011). Neonatal & pediatric pharmacology. Philadelphia: Lippincott Williams & Wilkins.
Session Outline
See handout on following pages.
