NUR 6121 Exam 1 - Advanced Practice Nursing II - … 2026/2027 • Verified • Assured Grade A+
✓ VERIFIED • 2026/2027 UPDATE • 100% ACCURATE
NUR 6121 Exam 1 - Advanced Practice Nursing II - NP Exam
Prep 2026/2027 UPDATE |WPU
ACTUAL EXAM QUESTIONS & VERIFIED ANSWERS
with Clear, Detailed Rationales
Document Type: Exam (Elaborations) / Study Guide
Academic Year:
Total Questions: 50 Multiple Choice
Includes: Correct Answers + Rationales
Grade: A+ Assured
ASSURED GRADE A+
Exam (Elaborations) • Detailed Rationales Page 1
,NUR 6121 Exam 1 - Advanced Practice Nursing II - … 2026/2027 • Verified • Assured Grade A+
Questions & Verified Answers
1. A 65-year-old patient with HFrEF (EF 30%) remains symptomatic on Lisinopril 20mg and
Carvedilol 25mg BID. What is the next evidence-based step to improve survival?
A. Add Amlodipine 5mg daily
B. Add Digoxin 0.125mg daily
C. Switch Lisinopril to Sacubitril/Valsartan
D. What is the next evidence-based step to improve survival?
Answer: C
Rationale: Switching an ACE inhibitor or ARB to an Angiotensin Receptor-Neprilysin Inhibitor (ARNI)
is recommended for patients with HFrEF to further reduce mortality and hospitalization. This
knowledge supports safe care and helps the nurse teach the client and family clearly and simply. Clear
teaching improves cooperation and reduces anxiety. Knowing the reason behind the correct answer
makes it easier to rule out the wrong options quickly. Look for the choice that protects the client and
matches the priority need.
2. According to GOLD 2024 guidelines, what is the initial treatment for a Group E COPD
patient?
A. LAMA monotherapy
B. LABA + LAMA combination
C. ICS + LABA combination
D. LABA + LAMA + ICS (Triple Therapy) if blood eosinophils >300
Answer: D
Rationale: Group E (Exacerbators) should start with LABA+LAMA; however, if blood eosinophils are
>=300 cells/uL, triple therapy (LABA+LAMA+ICS) is preferred. Knowing the reason behind the correct
answer makes it easier to rule out the wrong options quickly. Look for the choice that protects the client
and matches the priority need. Knowing the reason behind the correct answer makes it easier to rule
out the wrong options quickly. Look for the choice that protects the client and matches the priority
need.
Exam (Elaborations) • Detailed Rationales Page 2
, NUR 6121 Exam 1 - Advanced Practice Nursing II - … 2026/2027 • Verified • Assured Grade A+
3. Which laboratory finding is most specific for a diagnosis of Iron Deficiency Anemia in a
patient with chronic disease?
A. Low Serum Iron
B. Low Ferritin
C. Elevated Total Iron Binding Capacity (TIBC)
D. Low Mean Corpuscular Volume (MCV)
Answer: B
Rationale: Ferritin is the most sensitive and specific test for iron deficiency. While TIBC is often
elevated, low ferritin directly reflects depleted iron stores. Knowing the reason behind the correct
answer makes it easier to rule out the wrong options quickly. Look for the choice that protects the client
and matches the priority need. Understanding this helps the nurse notice early warning signs and act
before the problem gets worse. Early action often prevents bigger complications for the client.
4. A patient with Type 2 Diabetes and established Atherosclerotic Cardiovascular Disease
(ASCVD) should prioritize which medication class for glycemic control?
A. DPP-4 Inhibitors
B. GLP-1 Receptor Agonists with proven CVD benefit
C. Sulfonylureas
D. should prioritize which medication class for glycemic control?
Answer: B
Rationale: ADA guidelines recommend GLP-1 RAs or SGLT2 inhibitors with proven cardiovascular
benefit for patients with established ASCVD, regardless of A1c. Knowing the reason behind the correct
answer makes it easier to rule out the wrong options quickly. Look for the choice that protects the client
and matches the priority need. Understanding this helps the nurse notice early warning signs and act
before the problem gets worse. Early action often prevents bigger complications for the client.
Exam (Elaborations) • Detailed Rationales Page 3
✓ VERIFIED • 2026/2027 UPDATE • 100% ACCURATE
NUR 6121 Exam 1 - Advanced Practice Nursing II - NP Exam
Prep 2026/2027 UPDATE |WPU
ACTUAL EXAM QUESTIONS & VERIFIED ANSWERS
with Clear, Detailed Rationales
Document Type: Exam (Elaborations) / Study Guide
Academic Year:
Total Questions: 50 Multiple Choice
Includes: Correct Answers + Rationales
Grade: A+ Assured
ASSURED GRADE A+
Exam (Elaborations) • Detailed Rationales Page 1
,NUR 6121 Exam 1 - Advanced Practice Nursing II - … 2026/2027 • Verified • Assured Grade A+
Questions & Verified Answers
1. A 65-year-old patient with HFrEF (EF 30%) remains symptomatic on Lisinopril 20mg and
Carvedilol 25mg BID. What is the next evidence-based step to improve survival?
A. Add Amlodipine 5mg daily
B. Add Digoxin 0.125mg daily
C. Switch Lisinopril to Sacubitril/Valsartan
D. What is the next evidence-based step to improve survival?
Answer: C
Rationale: Switching an ACE inhibitor or ARB to an Angiotensin Receptor-Neprilysin Inhibitor (ARNI)
is recommended for patients with HFrEF to further reduce mortality and hospitalization. This
knowledge supports safe care and helps the nurse teach the client and family clearly and simply. Clear
teaching improves cooperation and reduces anxiety. Knowing the reason behind the correct answer
makes it easier to rule out the wrong options quickly. Look for the choice that protects the client and
matches the priority need.
2. According to GOLD 2024 guidelines, what is the initial treatment for a Group E COPD
patient?
A. LAMA monotherapy
B. LABA + LAMA combination
C. ICS + LABA combination
D. LABA + LAMA + ICS (Triple Therapy) if blood eosinophils >300
Answer: D
Rationale: Group E (Exacerbators) should start with LABA+LAMA; however, if blood eosinophils are
>=300 cells/uL, triple therapy (LABA+LAMA+ICS) is preferred. Knowing the reason behind the correct
answer makes it easier to rule out the wrong options quickly. Look for the choice that protects the client
and matches the priority need. Knowing the reason behind the correct answer makes it easier to rule
out the wrong options quickly. Look for the choice that protects the client and matches the priority
need.
Exam (Elaborations) • Detailed Rationales Page 2
, NUR 6121 Exam 1 - Advanced Practice Nursing II - … 2026/2027 • Verified • Assured Grade A+
3. Which laboratory finding is most specific for a diagnosis of Iron Deficiency Anemia in a
patient with chronic disease?
A. Low Serum Iron
B. Low Ferritin
C. Elevated Total Iron Binding Capacity (TIBC)
D. Low Mean Corpuscular Volume (MCV)
Answer: B
Rationale: Ferritin is the most sensitive and specific test for iron deficiency. While TIBC is often
elevated, low ferritin directly reflects depleted iron stores. Knowing the reason behind the correct
answer makes it easier to rule out the wrong options quickly. Look for the choice that protects the client
and matches the priority need. Understanding this helps the nurse notice early warning signs and act
before the problem gets worse. Early action often prevents bigger complications for the client.
4. A patient with Type 2 Diabetes and established Atherosclerotic Cardiovascular Disease
(ASCVD) should prioritize which medication class for glycemic control?
A. DPP-4 Inhibitors
B. GLP-1 Receptor Agonists with proven CVD benefit
C. Sulfonylureas
D. should prioritize which medication class for glycemic control?
Answer: B
Rationale: ADA guidelines recommend GLP-1 RAs or SGLT2 inhibitors with proven cardiovascular
benefit for patients with established ASCVD, regardless of A1c. Knowing the reason behind the correct
answer makes it easier to rule out the wrong options quickly. Look for the choice that protects the client
and matches the priority need. Understanding this helps the nurse notice early warning signs and act
before the problem gets worse. Early action often prevents bigger complications for the client.
Exam (Elaborations) • Detailed Rationales Page 3
