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USMLE Step 1 First Aid Exam Questions 2026 | Verified Answers & Detailed Solutions | Exam Prep

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Prepare for the USMLE Step 1 with a focused First Aid review resource featuring practice questions, verified answers, and detailed solutions. This material is designed to reinforce high yield medical concepts and support effective Step 1 exam preparation. Review essential areas including anatomy, biochemistry, immunology, microbiology, pathology, pharmacology, physiology, behavioral science, genetics, and biostatistics. Practice questions and detailed solutions can help strengthen understanding, identify knowledge gaps, and support focused review across major Step 1 disciplines. Whether you are searching for USMLE Step 1 practice questions, First Aid Step 1 questions and answers, USMLE Step 1 study guides, medical board exam prep, or Step 1 review materials for 2026, this resource provides structured content for focused preparation.

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1
Usmle




Usmle Step 1 First Aid Exam
Questions with Correct Verified
Solutions 100% Guaranteed Pass
Hypersensitivity vasculitis associated with hemorrhagic urticaria and
upper respiratory tract infections - diagnosis? - ANS ✓henoch-schonlein
purpura


Most common tumor of infancy - ANS ✓hemangioma



Charcot's triad of multiple sclerosis - ANS ✓nystagmus, intention
tremor, scanning speech (where the same emphasis is put on each syllable
like scanning a poem)


Most common causes of dic - ANS ✓gram-negative sepsis, obstetric
complications, cancer, burn trauma


Most common cause of myocarditis - ANS ✓coxsackie b



Kussmaul hyperpnea - diagnosis? - ANS ✓diabetic ketoacidosis



Lisch nodules - diagnosis? - ANS ✓neurofibromatosis (von
recklinghausen's disease)


Polyneuropathy, cardiac pathology, and edema - diagnosis?

Usmle Step 1 First Aid

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Usmle

- what causes it? - ANS ✓wet beriberi (vitamin b1 deficiency)


Most common malignancy associated with noninfectious fever - ANS
✓Hodgkin’s disease



Port-wine stain - diagnosis? - ANS ✓hemangioma


What is trousseau's sign of malignancy?

- possible diagnoses? - ANS ✓migratory thrombophlebitis
- visceral cancer or pancreatic adenocarcinoma


Homer wright rosettes - diagnosis? - ANS ✓neuroblastoma


What is trousseau's sign of latent tetany?

- diagnosis? - ANS ✓carpal spasm
- hypocalcemia


What is Virchow’s triad?

- predilection for what? - ANS ✓blood stasis, endothelial damage,
hypercoagulation
- pulmonary embolism


What is von recklinghausen's disease of bone? - ANS ✓osteitis fibrosa
cystica ("brown tumor")




Usmle Step 1 First Aid

, 3
Usmle

Adrenal hemorrhage associated with meningococcemia - diagnosis? -
ANS ✓waterhouse-friderichsen syndrome


Most common cause of hemochromatosis

- causes risk of? - ANS ✓multiple blood transfusions
- can cause chf and increased risk of hepatocellular carcinoma


Mechanism of action of macrolides and clindamycin? - ANS ✓bind 50s
subunit and block translocation


Most common cause of congenital adrenal hyperplasia - ANS ✓21-
hydroxylase deficiency


Most common tumor of the adrenal medulla in kids

- benign or malignant? - ANS ✓neuroblastoma - malignant



Most common cause of siadh - ANS ✓small cell carcinoma of the lung


Most common cause of cushing's syndrome

- 2nd most common? - ANS ✓corticosteroid therapy
- excess acth secretion by pituitary is 2nd


Most common cause of hypopituitarism - ANS ✓adenoma



Suboccipital lymphadenopathy - diagnosis? - ANS ✓rubella




Usmle Step 1 First Aid

, 4
Usmle

Most common vasculitis
- poses risk for?

- what causes this? - ANS ✓temporal arteritis
- risk of ipsilateral blindness - due to thrombosis of opthalmic artery


Most common cause of hepatocellular carcinoma - ANS ✓cirrhotic liver,
often due to hepatitis b and c


Most common cause of viral encephalitis - ANS ✓hsv


What is the defect in chediak-higashi syndrome?

- symptoms? - ANS ✓defect in microtubule polymerization, causing
decreased phagocytosis
- symptoms: recurrent pyogenic infections, partial albinism,
peripheral neuropathy


Most common cause of addison's

- 2nd most common? - ANS ✓autoimmune
- infection is 2nd


"smudge cell" - diagnosis? - ANS ✓cll



Most common cause of constrictive pericarditis - ANS ✓tuberculosis



Soap bubble on x-ray - diagnosis? - ANS ✓giant cell tumor of bone




Usmle Step 1 First Aid

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August 30, 2026
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