PATH 370 - quiz 2 (Ch. 10, 11, 13, 14, 15)
(2026/2027) High-Yield Questions &
Detailed Rationales – West Coast U,
Ontario
Ace your PATH 370 Quiz 2 with this complete, high-yield set of practice questions,
accurate answers, and detailed rationales.
Overview
• Course: PATH 370 (Pathophysiology)
• Assessment: In-Class Quiz 2
• Coverage: Chapters 10, 11, 13, 14, and 15
• Content: Verified questions, correct answers, and thorough clinical rationales.
Key Topics Covered
• Immunity & Hypersensitivity: Types I, II, III, and IV hypersensitivity reactions,
immune complexes, and mediators.
• Hematologic Disorders: RBC structure/function, anemias (aplastic, iron
deficiency, chronic renal failure), and deficiencies.
• WBC & Malignancies: Leukemias (CML, AML, CLL, ALL), multiple myeloma,
and lymphomas.
• Hemostasis & Coagulation: Platelet function, coagulation pathways, and
clotting disorders like DIC.
• Hemodynamics: Blood flow equations (\(Q = P/R\)), blood pressure, and
vascular obstructions (thrombus, embolus, atherosclerosis).
Why Buy This Resource?
• Clear Rationales: Every correct answer includes a step-by-step clinical
explanation so you understand the why, not just the what.
• Time Saver: Condenses five dense textbook chapters into high-yield, test-style
questions.
1
, • Tested Material: Focuses on the exact concepts frequently missed on in-class
pathophysiology quizzes.
1. Hemophilia B is also known as ________ disease
•
• Christmas
•
Rationale: Hemophilia B is a genetic bleeding disorder caused by a deficiency of blood
clotting Factor IX. It is widely known as Christmas disease, named after Stephen Christmas,
the first patient officially diagnosed with the distinct condition in 1952. This differentiated it
from Hemophilia A (Factor VIII deficiency).
2. The Philadelphia chromosome is a balanced chromosome
translocation that forms a new gene called
•
• bcr-abl
•
Rationale: The Philadelphia chromosome is a specific genetic abnormality resulting from a
reciprocal translocation between chromosomes 9 and 22, designated as t(9;22). This structural
swap fuses the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9. The
resulting BCR-ABL oncogene codes for a constitutively active tyrosine kinase, which drives
uncontrolled cellular proliferation in Chronic Myeloid Leukemia (CML).
3. Anemia related to vitamin B12 or folate deficiency is characterized by
what laboratory features? (Select all that apply.)
•
• RBC counts of 500,000 to 750,000 cells/mm³
• WBC counts of 4000 to 5000 cells/mm³
•
Rationale: Vitamin B12 and folate deficiencies impair DNA synthesis, which severely halts
the production and maturation of rapidly dividing cells in the bone marrow. This causes a drastic
drop in red blood cells (profound anemia with RBC counts dropping below 1 million
cells/mm³). Because DNA synthesis is a systemic requirement for all blood cell lines, it also
2
(2026/2027) High-Yield Questions &
Detailed Rationales – West Coast U,
Ontario
Ace your PATH 370 Quiz 2 with this complete, high-yield set of practice questions,
accurate answers, and detailed rationales.
Overview
• Course: PATH 370 (Pathophysiology)
• Assessment: In-Class Quiz 2
• Coverage: Chapters 10, 11, 13, 14, and 15
• Content: Verified questions, correct answers, and thorough clinical rationales.
Key Topics Covered
• Immunity & Hypersensitivity: Types I, II, III, and IV hypersensitivity reactions,
immune complexes, and mediators.
• Hematologic Disorders: RBC structure/function, anemias (aplastic, iron
deficiency, chronic renal failure), and deficiencies.
• WBC & Malignancies: Leukemias (CML, AML, CLL, ALL), multiple myeloma,
and lymphomas.
• Hemostasis & Coagulation: Platelet function, coagulation pathways, and
clotting disorders like DIC.
• Hemodynamics: Blood flow equations (\(Q = P/R\)), blood pressure, and
vascular obstructions (thrombus, embolus, atherosclerosis).
Why Buy This Resource?
• Clear Rationales: Every correct answer includes a step-by-step clinical
explanation so you understand the why, not just the what.
• Time Saver: Condenses five dense textbook chapters into high-yield, test-style
questions.
1
, • Tested Material: Focuses on the exact concepts frequently missed on in-class
pathophysiology quizzes.
1. Hemophilia B is also known as ________ disease
•
• Christmas
•
Rationale: Hemophilia B is a genetic bleeding disorder caused by a deficiency of blood
clotting Factor IX. It is widely known as Christmas disease, named after Stephen Christmas,
the first patient officially diagnosed with the distinct condition in 1952. This differentiated it
from Hemophilia A (Factor VIII deficiency).
2. The Philadelphia chromosome is a balanced chromosome
translocation that forms a new gene called
•
• bcr-abl
•
Rationale: The Philadelphia chromosome is a specific genetic abnormality resulting from a
reciprocal translocation between chromosomes 9 and 22, designated as t(9;22). This structural
swap fuses the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9. The
resulting BCR-ABL oncogene codes for a constitutively active tyrosine kinase, which drives
uncontrolled cellular proliferation in Chronic Myeloid Leukemia (CML).
3. Anemia related to vitamin B12 or folate deficiency is characterized by
what laboratory features? (Select all that apply.)
•
• RBC counts of 500,000 to 750,000 cells/mm³
• WBC counts of 4000 to 5000 cells/mm³
•
Rationale: Vitamin B12 and folate deficiencies impair DNA synthesis, which severely halts
the production and maturation of rapidly dividing cells in the bone marrow. This causes a drastic
drop in red blood cells (profound anemia with RBC counts dropping below 1 million
cells/mm³). Because DNA synthesis is a systemic requirement for all blood cell lines, it also
2
